{
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      "interpretation": "The source object contains no age or independent sample metadata.",
      "reason_code": "age_metadata_absent",
      "status": "not_computed"
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      "interpretation": "Cross-tissue ligand-receptor co-expression was not reported as cell communication.",
      "reason_code": "cross_tissue_communication_invalid",
      "status": "not_computed"
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      "interpretation": "Expression-correlation modules in the stratified sample; not donor-level network comparison.",
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        "10": 3,
        "11": 6,
        "12": 2,
        "13": 1953,
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        "15": 1,
        "16": 1,
        "17": 1,
        "18": 1,
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        "20": 1,
        "21": 1,
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        "23": 2,
        "24": 1,
        "25": 1,
        "26": 1,
        "27": 1,
        "28": 1,
        "29": 1,
        "3": 1,
        "30": 1,
        "4": 1,
        "5": 6,
        "6": 2,
        "7": 2,
        "8": 1,
        "9": 2
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      "n_genes_analyzed": 2000,
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      "generated_at": "2026-08-08T06:34:43.573328Z",
      "independent_biological_replicates": false,
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      "interpretation": "Cell-level descriptive marker ranking. Adjusted p-values do not replace independent biological replicates.",
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      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated disease-gene set overlap; descriptive only.",
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        "Multiple sclerosis",
        "Autism spectrum disorder",
        "Cardiovascular disease",
        "Type 2 diabetes"
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      "validated_exploratory": true
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    "drug": {
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      "data_id": "SP121",
      "drugs_screened": 18,
      "drugs_with_targets": 18,
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      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated drug-target expression matching; descriptive only.",
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      "status": "validated_exploratory",
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        "Dexamethasone",
        "Ruxolitinib",
        "Erlotinib",
        "Tocilizumab"
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      "background_type": "genes detected in the SP121 tissue-by-cell-type stratified sample",
      "biological_replicates_available": false,
      "caution": "Fixed-seed tissue-by-cell-type stratified sample; cell-level descriptive analysis only. No donor-level biological replication or age/condition inference.",
      "celltypes_analyzed": 107,
      "data_id": "SP121",
      "directions": [
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      "generated_at": "2026-08-08T06:34:43.573328Z",
      "go_terms_found": 96391,
      "independent_biological_replicates": false,
      "inference_scope": "descriptive_cell_level",
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Frozen GO and KEGG over-representation analysis of descriptive marker signatures.",
      "kegg_pathways_found": 16951,
      "method": "one-sided hypergeometric ORA with BH correction",
      "method_implementation": "validated_real_method_and_resources",
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      "multiple_testing_interpretation": "descriptive enrichment of sampled cell-type marker signatures",
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        "GO_Cellular_Component_2026": "GO_Cellular_Component_2026",
        "GO_Molecular_Function_2026": "GO_Molecular_Function_2026",
        "KEGG_2026": "KEGG_2026"
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      "generated_at": "2026-08-08T06:34:43.573328Z",
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      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Pearson TF-target associations in the stratified sample; not causal regulatory-network inference.",
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        "EGR1": 132,
        "FOS": 132,
        "IRF1": 76,
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        "MYC": 64,
        "NFKB1": 110,
        "RB1": 70,
        "RUNX1": 95,
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      "total_tf_target_pairs": 1511,
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      "generated_at": "2026-08-08T06:34:43.573328Z",
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      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated metabolic gene-set expression scores; descriptive only.",
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        "Glycolysis",
        "Pentose Phosphate",
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        "Glutamine Metabolism"
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      "celltypes_analyzed": 107,
      "ctx_enrichment_rows_reported": 22788,
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      "inferential_scope": "descriptive_cell_level",
      "interpretation": "cisTarget gene-set motif enrichment; this is not a full pySCENIC GRN.",
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      "signatures_reported_by_ctx": 212,
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        "signature_index": {
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      "source_sample_manifest": {
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      "validated_exploratory": true,
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    },
    "toppgene": {
      "analysis_scope": "exploratory_stratified_sample",
      "background_type": "toppgene_internal",
      "biological_replicates_available": false,
      "caution": "Fixed-seed tissue-by-cell-type stratified sample; cell-level descriptive analysis only. No donor-level biological replication or age/condition inference.",
      "celltypes_analyzed": 107,
      "data_id": "SP121",
      "directions": [
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        "down"
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      "generated_at": "2026-08-08T06:34:43.573328Z",
      "independent_biological_replicates": false,
      "inference_scope": "descriptive_cell_level",
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Official ToppGene API enrichment of descriptive marker signatures.",
      "method": "official ToppGene lookup and enrich APIs",
      "method_implementation": "validated_real_method_and_resources",
      "method_status": "validated_exploratory",
      "minimum_mapped_genes": 1,
      "minimum_mapping_rate": 0.7,
      "release_id": "sp121-advanced-r20260808-exploratory1",
      "resource_version": "ToppGene-2026-Mar-24-build-54-e86be7ae11697afda22f75dc39e98b6cec88a0f1",
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        "seed": 12120260808,
        "source_cells": 1246365,
        "strategy": "tissue_cell_type_stratified"
      },
      "service": "official ToppGene lookup and enrich APIs",
      "small_signature_policy": "retain direction-specific signatures with at least one mapped gene; interpret very small signatures as exploratory",
      "source_sample_manifest": {
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        "path": "internal_path_redacted",
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      "total_enrichments": 180015,
      "validated_exploratory": true,
      "validated_real": false
    },
    "trajectory": {
      "interpretation": "No common lineage, biological root, or time axis is available across 47 tissues.",
      "reason_code": "mixed_tissue_no_lineage_or_root",
      "status": "not_computed"
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  "analysis_scope": "exploratory_stratified_sample",
  "data_id": "SP121",
  "data_limitations": [
    "No donor, individual, sample, age, condition, or treatment field.",
    "No raw counts layer; X is log1p(CP10K).",
    "FolderID is a source batch and is confounded with tissue.",
    "Results are descriptive and not donor-level inference."
  ],
  "generated_at": "2026-08-08T06:34:43.573328Z",
  "release_id": "sp121-advanced-r20260808-exploratory1",
  "sample_cells": 44523,
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  "source_cells": 1246365,
  "status": "validated_exploratory",
  "validated_exploratory": true
}