Analysis Report - sys04tis01

📡 Cell-Cell Communication

total_interactions: 9563

unique_pathways: 29

top_pathway: TGFb

top_source: Fibroblasts

top_target: Neutrophils

cellchat/cellchat_heatmap.png

cellchat/cellchat_network.png

🔗 Co-expression Network

n_modules: 30

n_genes_analyzed: 2000

coexpression/coexp_dendrogram.png

coexpression/coexp_module_heatmap.png

🧬 Gene Regulatory Network

total_tfs_analyzed: 95

total_tf_target_pairs: 1988

grn/grn_tf_heatmap.png

grn/grn_network.png

🔀 Trajectory Analysis

n_cells: 50929

root_celltype: Club cells

terminal_celltype: B cells

velocity_available: False

n_celltypes: 18

trajectory/trajectory_pseudotime_umap.png

trajectory/trajectory_paga.png

📊 Differential Expression

total_degs_tested: 1800

significant_degs: 1800

n_celltypes: 18

deg/deg_volcano.png

deg/deg_marker_heatmap.png

⚗️ Metabolism

pathways_scored: 12

pathways_detected: 12

celltypes_analyzed: 18

metabolism/metabolism_heatmap.png

metabolism/metabolism_dotplot.png

🏥 Disease Association

diseases_tested: 15

significant_associations: 20

disease/disease_heatmap.png

disease/disease_dotplot.png

💊 Drug Analysis

drugs_screened: 18

drugs_with_targets: 18

celltypes_analyzed: 18

drug/drug_heatmap.png

drug/drug_dotplot.png

🎯 GO / KEGG Enrichment

Direction-separated hypergeometric over-representation analysis using the SP121 detected-gene background and frozen 2026 libraries.

GO_enrichment

KEGG_enrichment

🧪 ToppGene Enrichment

Official ToppGene lookup and enrichment APIs; ToppGene internal annotation background.

ToppGene_enrichment

🔠 cisTarget Motif Enrichment

pySCENIC cisTarget gene-set motif enrichment using frozen hg38 refseq_r80 mc_v10_clust ranking databases.

cisTarget_motif_enrichment