{
  "analyses": {
    "age_association": {
      "reason_code": "age_metadata_absent",
      "status": "not_computed"
    },
    "cellchat": {
      "reason_code": "disabled_cross_tissue",
      "status": "not_computed"
    },
    "coexpression": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP191",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Exploratory expression-correlation modules.",
      "method_status": "validated_exploratory",
      "module_sizes": {
        "1": 3,
        "10": 2,
        "11": 3,
        "12": 9,
        "13": 9,
        "14": 5,
        "15": 5,
        "16": 7,
        "17": 4,
        "18": 6,
        "19": 1,
        "2": 2,
        "20": 11,
        "21": 6,
        "22": 11,
        "23": 4,
        "24": 10,
        "25": 3,
        "26": 8,
        "27": 8,
        "28": 8,
        "29": 8,
        "3": 3,
        "30": 1841,
        "4": 2,
        "5": 2,
        "6": 2,
        "7": 8,
        "8": 6,
        "9": 3
      },
      "n_genes_analyzed": 2000,
      "n_modules": 30,
      "sampling": {
        "n_cells": 2235,
        "seed": 20260808,
        "source_cells": 16715,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "validated_exploratory": true
    },
    "deg": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP191",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Descriptive cell-level marker ranking; not donor-level inference.",
      "method_status": "validated_exploratory",
      "n_celltypes": 9,
      "sampling": {
        "n_cells": 2235,
        "seed": 20260808,
        "source_cells": 16715,
        "strategy": "tissue_cell_type_stratified"
      },
      "significant_degs": 900,
      "status": "validated_exploratory",
      "total_degs_tested": 900,
      "validated_exploratory": true
    },
    "disease": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP191",
      "diseases_tested": 15,
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated disease-gene overlap; descriptive only.",
      "method_status": "validated_exploratory",
      "sampling": {
        "n_cells": 2235,
        "seed": 20260808,
        "source_cells": 16715,
        "strategy": "tissue_cell_type_stratified"
      },
      "significant_associations": 10,
      "status": "validated_exploratory",
      "top_diseases": [
        "Autism spectrum disorder",
        "Systemic lupus erythematosus",
        "Schizophrenia",
        "Autism spectrum disorder",
        "Autism spectrum disorder"
      ],
      "validated_exploratory": true
    },
    "drug": {
      "analysis_scope": "exploratory_stratified_sample",
      "celltypes_analyzed": 9,
      "data_id": "SP191",
      "drugs_screened": 18,
      "drugs_with_targets": 17,
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated drug-target expression matching; descriptive only.",
      "method_status": "validated_exploratory",
      "sampling": {
        "n_cells": 2235,
        "seed": 20260808,
        "source_cells": 16715,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "top_drugs": [
        "Cyclosporine",
        "Dexamethasone",
        "Erlotinib",
        "Ruxolitinib",
        "Tocilizumab"
      ],
      "validated_exploratory": true
    },
    "grn": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP191",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Exploratory TF-target associations; not causal inference.",
      "method_status": "validated_exploratory",
      "sampling": {
        "n_cells": 2235,
        "seed": 20260808,
        "source_cells": 16715,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "top_tfs": {
        "CEBPA": 28,
        "FOS": 14,
        "IRF1": 16,
        "NFKB1": 11,
        "OTX2": 29,
        "RB1": 18,
        "RUNX1": 57,
        "RUNX2": 18,
        "SOX9": 16,
        "TCF7": 9
      },
      "total_tf_target_pairs": 291,
      "total_tfs_analyzed": 83,
      "validated_exploratory": true
    },
    "metabolism": {
      "analysis_scope": "exploratory_stratified_sample",
      "celltypes_analyzed": 9,
      "data_id": "SP191",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated metabolic gene-set scores; descriptive only.",
      "method_status": "validated_exploratory",
      "pathways_detected": 12,
      "pathways_scored": 12,
      "sampling": {
        "n_cells": 2235,
        "seed": 20260808,
        "source_cells": 16715,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "top_pathways": [
        "Fatty Acid Synthesis",
        "Fatty Acid Oxidation",
        "Glutamine Metabolism",
        "TCA Cycle",
        "Oxidative Phosphorylation"
      ],
      "validated_exploratory": true
    },
    "trajectory": {
      "reason_code": "no_lineage_root",
      "status": "not_computed"
    }
  },
  "analysis_scope": "exploratory_stratified_sample",
  "data_id": "SP191",
  "generated_at": "2026-08-08T08:17:27.151709Z",
  "sample_cells": 2235,
  "sampling": {
    "n_cells": 2235,
    "seed": 20260808,
    "source_cells": 16715,
    "strategy": "tissue_cell_type_stratified"
  },
  "schema_version": 1,
  "source_cells": 16715,
  "status": "validated_exploratory",
  "validated_exploratory": true
}