{
  "data_id": "sys04",
  "generated_at": "2026-02-24T10:12:32.623007",
  "analyses": {
    "cellchat": {
      "total_interactions": 3073,
      "unique_pathways": 27,
      "top_pathway": "VEGF",
      "top_source": "Alveolar type 1 cells",
      "top_target": "Club cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 87,
      "top_tfs": {
        "FOXA1": 19,
        "RUNX1": 18,
        "LEF1": 14,
        "RUNX2": 10,
        "GATA3": 7,
        "GATA2": 5,
        "FOS": 4,
        "SOX9": 3,
        "TCF7": 3,
        "EGR1": 2
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
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        "5": 3,
        "4": 2,
        "2": 2,
        "1": 2,
        "3": 2,
        "11": 1,
        "7": 1,
        "15": 1,
        "27": 1,
        "16": 1,
        "12": 1,
        "28": 1,
        "29": 1,
        "10": 1,
        "30": 1,
        "24": 1,
        "19": 1,
        "9": 1,
        "26": 1,
        "25": 1,
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        "22": 1,
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        "23": 1,
        "8": 1
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    },
    "deg": {
      "total_degs_tested": 1300,
      "significant_degs": 1227,
      "n_celltypes": 13,
      "top_upregulated": [
        {
          "names": "CRTAC1",
          "cell_type": "Mesothelial cells",
          "logfoldchanges": 8.611997604370117
        },
        {
          "names": "UPK1B",
          "cell_type": "Mesothelial cells",
          "logfoldchanges": 8.497637748718262
        },
        {
          "names": "WT1",
          "cell_type": "Mesothelial cells",
          "logfoldchanges": 8.331448554992676
        },
        {
          "names": "RTKN2",
          "cell_type": "Alveolar type 1 cells",
          "logfoldchanges": 7.488015174865723
        },
        {
          "names": "IL7R",
          "cell_type": "DN T cells",
          "logfoldchanges": 7.346465587615967
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 117,
      "kegg_pathways_found": 104,
      "celltypes_analyzed": 13
    },
    "toppgene": {
      "celltypes_analyzed": 13,
      "total_enrichments": 286
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 183
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 15,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Multiple sclerosis",
        "Multiple sclerosis",
        "Autism spectrum disorder",
        "Autism spectrum disorder"
      ]
    }
  }
}