{
  "data_id": "sys05",
  "generated_at": "2026-02-24T10:26:33.538645",
  "analyses": {
    "cellchat": {
      "total_interactions": 27461,
      "unique_pathways": 27,
      "top_pathway": "CXCL",
      "top_source": "Fibroblasts",
      "top_target": "Innate lymphoid cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 1039,
      "top_tfs": {
        "FOS": 154,
        "JUN": 134,
        "HNF4A": 111,
        "EGR1": 66,
        "CEBPB": 56,
        "RUNX1": 55,
        "IRF1": 55,
        "FOXA1": 47,
        "GATA4": 41,
        "MYC": 36
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
        "5": 1969,
        "3": 2,
        "4": 2,
        "1": 1,
        "19": 1,
        "12": 1,
        "14": 1,
        "29": 1,
        "21": 1,
        "9": 1,
        "8": 1,
        "22": 1,
        "27": 1,
        "10": 1,
        "26": 1,
        "24": 1,
        "25": 1,
        "28": 1,
        "13": 1,
        "18": 1,
        "17": 1,
        "11": 1,
        "30": 1,
        "16": 1,
        "15": 1,
        "7": 1,
        "6": 1,
        "20": 1,
        "2": 1,
        "23": 1
      }
    },
    "deg": {
      "total_degs_tested": 3500,
      "significant_degs": 3450,
      "n_celltypes": 35,
      "top_upregulated": [
        {
          "names": "JCHAIN",
          "cell_type": "Plasma B cells",
          "logfoldchanges": 11.464359283447266
        },
        {
          "names": "CDH19",
          "cell_type": "Enteric glial cells",
          "logfoldchanges": 11.261375427246094
        },
        {
          "names": "CMTM5",
          "cell_type": "Enteric glial cells",
          "logfoldchanges": 10.760587692260742
        },
        {
          "names": "CHL1",
          "cell_type": "Enteric glial cells",
          "logfoldchanges": 10.553670883178711
        },
        {
          "names": "PGC",
          "cell_type": "Chief cells",
          "logfoldchanges": 10.467387199401855
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 315,
      "kegg_pathways_found": 280,
      "celltypes_analyzed": 35
    },
    "toppgene": {
      "celltypes_analyzed": 35,
      "total_enrichments": 770
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 514
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 29,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Alzheimer disease",
        "Alzheimer disease",
        "Multiple sclerosis",
        "Systemic lupus erythematosus"
      ]
    }
  }
}