{
  "data_id": "sys09",
  "generated_at": "2026-02-24T10:13:45.493302",
  "analyses": {
    "cellchat": {
      "total_interactions": 5799,
      "unique_pathways": 26,
      "top_pathway": "IGF",
      "top_source": "Macrophages",
      "top_target": "CD4+ T cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 342,
      "top_tfs": {
        "RUNX1": 84,
        "HNF4A": 76,
        "GATA3": 68,
        "FOXA1": 50,
        "GATA2": 39,
        "RUNX2": 19,
        "TP53": 5,
        "STAT3": 1
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
        "2": 1970,
        "1": 2,
        "23": 1,
        "14": 1,
        "15": 1,
        "30": 1,
        "20": 1,
        "16": 1,
        "4": 1,
        "26": 1,
        "13": 1,
        "25": 1,
        "18": 1,
        "8": 1,
        "24": 1,
        "7": 1,
        "6": 1,
        "9": 1,
        "12": 1,
        "10": 1,
        "21": 1,
        "5": 1,
        "19": 1,
        "27": 1,
        "11": 1,
        "28": 1,
        "17": 1,
        "22": 1,
        "29": 1,
        "3": 1
      }
    },
    "deg": {
      "total_degs_tested": 1900,
      "significant_degs": 1780,
      "n_celltypes": 18,
      "top_upregulated": [
        {
          "names": "NPHS1",
          "cell_type": "Podocytes",
          "logfoldchanges": 11.90349006652832
        },
        {
          "names": "CLEC4A",
          "cell_type": "Podocytes",
          "logfoldchanges": 10.865880966186523
        },
        {
          "names": "PTPRQ",
          "cell_type": "Podocytes",
          "logfoldchanges": 10.377496719360352
        },
        {
          "names": "NPHS2",
          "cell_type": "Podocytes",
          "logfoldchanges": 10.346636772155762
        },
        {
          "names": "CENPE",
          "cell_type": "Cycling urothelial cells",
          "logfoldchanges": 10.00627613067627
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 162,
      "kegg_pathways_found": 144,
      "celltypes_analyzed": 18
    },
    "toppgene": {
      "celltypes_analyzed": 18,
      "total_enrichments": 396
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 259
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 16,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Breast cancer",
        "Autism spectrum disorder",
        "Autism spectrum disorder",
        "Rheumatoid arthritis"
      ]
    }
  }
}