{
  "data_id": "sys02tis01",
  "generated_at": "2026-02-24T09:47:54.395167",
  "analyses": {
    "cellchat": {
      "total_interactions": 4806,
      "unique_pathways": 26,
      "top_pathway": "FGF",
      "top_source": "Fibroblasts",
      "top_target": "Pacemaker cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 616,
      "top_tfs": {
        "LEF1": 115,
        "RUNX1": 82,
        "FOS": 80,
        "GATA4": 72,
        "RUNX2": 63,
        "JUN": 53,
        "CEBPB": 35,
        "TCF7": 34,
        "IRF4": 28,
        "GATA2": 19
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
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        "17": 3,
        "11": 3,
        "9": 2,
        "8": 2,
        "3": 2,
        "16": 2,
        "4": 2,
        "6": 2,
        "5": 2,
        "15": 2,
        "29": 2,
        "14": 2,
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        "19": 1,
        "20": 1,
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        "28": 1,
        "12": 1,
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        "26": 1,
        "25": 1,
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        "1": 1,
        "2": 1
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    },
    "deg": {
      "total_degs_tested": 1600,
      "significant_degs": 1515,
      "n_celltypes": 16,
      "top_upregulated": [
        {
          "names": "RHCG",
          "cell_type": "Parathyroid cells",
          "logfoldchanges": 12.4855375289917
        },
        {
          "names": "GCM2",
          "cell_type": "Parathyroid cells",
          "logfoldchanges": 11.66812801361084
        },
        {
          "names": "CHGA",
          "cell_type": "Parathyroid cells",
          "logfoldchanges": 10.303119659423828
        },
        {
          "names": "PTH",
          "cell_type": "Parathyroid cells",
          "logfoldchanges": 9.265655517578125
        },
        {
          "names": "STAC",
          "cell_type": "Parathyroid cells",
          "logfoldchanges": 9.199392318725586
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 144,
      "kegg_pathways_found": 128,
      "celltypes_analyzed": 16
    },
    "toppgene": {
      "celltypes_analyzed": 16,
      "total_enrichments": 352
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 232
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 13,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Inflammatory bowel disease",
        "Schizophrenia",
        "Autism spectrum disorder",
        "Schizophrenia"
      ]
    }
  }
}