{
  "data_id": "sys02tis02",
  "generated_at": "2026-02-24T09:49:34.972535",
  "analyses": {
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      "total_interactions": 4526,
      "unique_pathways": 26,
      "top_pathway": "CXCL",
      "top_source": "DN T cells",
      "top_target": "Neutrophils"
    },
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      "total_tf_target_pairs": 463,
      "top_tfs": {
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        "GATA1": 47,
        "FOS": 43,
        "RUNX2": 37,
        "MYC": 37,
        "CEBPB": 35,
        "LEF1": 34,
        "RB1": 33,
        "IRF4": 28,
        "TCF7": 27
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    "coexp": {
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      "n_genes_analyzed": 2000,
      "module_sizes": {
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        "9": 3,
        "7": 2,
        "8": 2,
        "5": 2,
        "1": 1,
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    },
    "deg": {
      "total_degs_tested": 1700,
      "significant_degs": 1687,
      "n_celltypes": 17,
      "top_upregulated": [
        {
          "names": "CMA1",
          "cell_type": "Mast cells",
          "logfoldchanges": 10.12120246887207
        },
        {
          "names": "TM4SF1",
          "cell_type": "Common myeloid progenitors",
          "logfoldchanges": 9.462413787841797
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        {
          "names": "PRDM1",
          "cell_type": "Plasma B cells",
          "logfoldchanges": 9.124812126159668
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        {
          "names": "JCHAIN",
          "cell_type": "Plasma B cells",
          "logfoldchanges": 9.065923690795898
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        {
          "names": "MZB1",
          "cell_type": "Plasma B cells",
          "logfoldchanges": 9.025267601013184
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    "enrichment": {
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      "kegg_pathways_found": 136,
      "celltypes_analyzed": 17
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    "toppgene": {
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      "total_enrichments": 374
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 245
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 5,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Multiple sclerosis",
        "Systemic lupus erythematosus",
        "Multiple sclerosis",
        "Alzheimer disease"
      ]
    }
  }
}