{
  "data_id": "sys02tis03",
  "generated_at": "2026-02-24T09:48:16.546865",
  "analyses": {
    "cellchat": {
      "total_interactions": 2538,
      "unique_pathways": 23,
      "top_pathway": "CXCL",
      "top_source": "Monocytes",
      "top_target": "Monocytes"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 562,
      "top_tfs": {
        "FOS": 64,
        "EGR1": 63,
        "CEBPB": 58,
        "LEF1": 57,
        "TCF7": 51,
        "IRF1": 40,
        "GATA3": 37,
        "TP53": 28,
        "RUNX2": 28,
        "MYC": 24
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
        "1": 1971,
        "10": 1,
        "15": 1,
        "21": 1,
        "24": 1,
        "30": 1,
        "22": 1,
        "27": 1,
        "29": 1,
        "18": 1,
        "4": 1,
        "25": 1,
        "7": 1,
        "23": 1,
        "26": 1,
        "2": 1,
        "5": 1,
        "3": 1,
        "17": 1,
        "8": 1,
        "13": 1,
        "6": 1,
        "19": 1,
        "16": 1,
        "11": 1,
        "14": 1,
        "28": 1,
        "9": 1,
        "20": 1,
        "12": 1
      }
    },
    "deg": {
      "total_degs_tested": 1300,
      "significant_degs": 1299,
      "n_celltypes": 13,
      "top_upregulated": [
        {
          "names": "CPA3",
          "cell_type": "Basophils",
          "logfoldchanges": 11.617276191711426
        },
        {
          "names": "GP9",
          "cell_type": "Platelets",
          "logfoldchanges": 11.28246021270752
        },
        {
          "names": "NRGN",
          "cell_type": "Platelets",
          "logfoldchanges": 11.277544975280762
        },
        {
          "names": "PHOSPHO1",
          "cell_type": "Erythroid cells",
          "logfoldchanges": 11.262716293334961
        },
        {
          "names": "MS4A2",
          "cell_type": "Basophils",
          "logfoldchanges": 11.19912052154541
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 117,
      "kegg_pathways_found": 104,
      "celltypes_analyzed": 13
    },
    "toppgene": {
      "celltypes_analyzed": 13,
      "total_enrichments": 286
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 182
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 9,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Systemic lupus erythematosus",
        "Multiple sclerosis",
        "Systemic lupus erythematosus",
        "Multiple sclerosis"
      ]
    }
  }
}