{
  "data_id": "sys02tis04",
  "generated_at": "2026-02-24T09:49:51.587036",
  "analyses": {
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      "total_interactions": 4784,
      "unique_pathways": 27,
      "top_pathway": "CXCL",
      "top_source": "Fibroblasts",
      "top_target": "Fibroblasts"
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      "total_tf_target_pairs": 631,
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        "LEF1": 50,
        "EGR1": 50,
        "GATA1": 48,
        "TCF7": 48,
        "GATA3": 44,
        "RUNX2": 30,
        "JUN": 29,
        "TP53": 27
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      "n_genes_analyzed": 2000,
      "module_sizes": {
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        "3": 2,
        "1": 2,
        "6": 2,
        "4": 2,
        "5": 2,
        "2": 2,
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    },
    "deg": {
      "total_degs_tested": 1600,
      "significant_degs": 1573,
      "n_celltypes": 16,
      "top_upregulated": [
        {
          "names": "PPBP",
          "cell_type": "Platelets",
          "logfoldchanges": 14.055827140808105
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        {
          "names": "MPIG6B",
          "cell_type": "Platelets",
          "logfoldchanges": 14.040081977844238
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        {
          "names": "PTN",
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          "logfoldchanges": 13.572805404663086
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        {
          "names": "GP9",
          "cell_type": "Platelets",
          "logfoldchanges": 12.834405899047852
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        {
          "names": "CPA3",
          "cell_type": "Mast cells",
          "logfoldchanges": 12.827914237976074
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    "enrichment": {
      "go_terms_found": 144,
      "kegg_pathways_found": 128,
      "celltypes_analyzed": 16
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    "toppgene": {
      "celltypes_analyzed": 16,
      "total_enrichments": 352
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 225
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 14,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Type 2 diabetes",
        "Alzheimer disease",
        "Alzheimer disease",
        "Obesity"
      ]
    }
  }
}