{
  "data_id": "sys02tis05",
  "generated_at": "2026-02-24T09:47:15.436410",
  "analyses": {
    "cellchat": {
      "total_interactions": 2197,
      "unique_pathways": 27,
      "top_pathway": "IGF",
      "top_source": "Macrophages",
      "top_target": "Adipocytes"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 72,
      "top_tfs": {
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        "SOX9": 12,
        "FOXA1": 10,
        "GATA4": 3,
        "TCF7": 3,
        "GATA1": 3,
        "NFKB1": 1,
        "CEBPA": 1,
        "FOS": 1,
        "RUNX2": 1
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
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        "13": 4,
        "9": 4,
        "8": 3,
        "11": 3,
        "5": 3,
        "10": 3,
        "15": 2,
        "3": 2,
        "12": 2,
        "16": 2,
        "6": 1,
        "14": 1,
        "22": 1,
        "24": 1,
        "1": 1,
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        "19": 1,
        "7": 1,
        "27": 1,
        "28": 1,
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        "30": 1,
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        "18": 1,
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    },
    "deg": {
      "total_degs_tested": 1200,
      "significant_degs": 977,
      "n_celltypes": 11,
      "top_upregulated": [
        {
          "names": "PRR16",
          "cell_type": "Adipocytes",
          "logfoldchanges": 9.017534255981445
        },
        {
          "names": "LGALS12",
          "cell_type": "Adipocytes",
          "logfoldchanges": 9.00286865234375
        },
        {
          "names": "GYS2",
          "cell_type": "Adipocytes",
          "logfoldchanges": 8.858500480651855
        },
        {
          "names": "PLIN4",
          "cell_type": "Adipocytes",
          "logfoldchanges": 8.686849594116211
        },
        {
          "names": "KLB",
          "cell_type": "Adipocytes",
          "logfoldchanges": 8.651987075805664
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 99,
      "kegg_pathways_found": 88,
      "celltypes_analyzed": 11
    },
    "toppgene": {
      "celltypes_analyzed": 11,
      "total_enrichments": 242
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 158
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 11,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Schizophrenia",
        "Multiple sclerosis",
        "Systemic lupus erythematosus",
        "Autism spectrum disorder"
      ]
    }
  }
}