{
  "data_id": "sys05tis01",
  "generated_at": "2026-02-24T09:42:51.000404",
  "analyses": {
    "cellchat": {
      "total_interactions": 376,
      "unique_pathways": 23,
      "top_pathway": "IGF",
      "top_source": "Stellate cells",
      "top_target": "Endothelial cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 32,
      "top_tfs": {
        "HNF4A": 15,
        "LEF1": 5,
        "GATA3": 4,
        "RUNX2": 3,
        "TCF7": 2,
        "SOX9": 1,
        "IRF4": 1,
        "BATF": 1
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
        "25": 1925,
        "12": 7,
        "10": 7,
        "18": 5,
        "22": 4,
        "3": 3,
        "23": 3,
        "24": 3,
        "19": 3,
        "1": 3,
        "7": 3,
        "20": 3,
        "13": 3,
        "6": 3,
        "14": 3,
        "17": 2,
        "21": 2,
        "16": 2,
        "15": 2,
        "8": 2,
        "5": 2,
        "9": 2,
        "4": 1,
        "28": 1,
        "11": 1,
        "29": 1,
        "2": 1,
        "26": 1,
        "27": 1,
        "30": 1
      }
    },
    "deg": {
      "total_degs_tested": 500,
      "significant_degs": 497,
      "n_celltypes": 5,
      "top_upregulated": [
        {
          "names": "IL7R",
          "cell_type": "DN T cells",
          "logfoldchanges": 7.6477837562561035
        },
        {
          "names": "ITK",
          "cell_type": "DN T cells",
          "logfoldchanges": 7.440566062927246
        },
        {
          "names": "SKAP1",
          "cell_type": "DN T cells",
          "logfoldchanges": 7.202312469482422
        },
        {
          "names": "SCML4",
          "cell_type": "DN T cells",
          "logfoldchanges": 7.172537803649902
        },
        {
          "names": "STAB2",
          "cell_type": "Endothelial cells",
          "logfoldchanges": 6.869997024536133
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 45,
      "kegg_pathways_found": 40,
      "celltypes_analyzed": 5
    },
    "toppgene": {
      "celltypes_analyzed": 5,
      "total_enrichments": 110
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 72
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 4,
      "top_diseases": [
        "Multiple sclerosis",
        "Inflammatory bowel disease",
        "Type 2 diabetes",
        "Cardiovascular disease"
      ]
    }
  }
}