{
  "data_id": "sys05tis04",
  "generated_at": "2026-02-24T09:51:46.741578",
  "analyses": {
    "cellchat": {
      "total_interactions": 640,
      "unique_pathways": 20,
      "top_pathway": "VEGF",
      "top_source": "Endocrine cells",
      "top_target": "Mast cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 6,
      "top_tfs": {
        "SOX9": 3,
        "PAX6": 2,
        "LEF1": 1
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
        "29": 1825,
        "27": 10,
        "14": 10,
        "11": 10,
        "19": 9,
        "22": 9,
        "12": 9,
        "9": 8,
        "15": 8,
        "4": 8,
        "6": 8,
        "28": 7,
        "26": 7,
        "18": 7,
        "25": 6,
        "20": 6,
        "13": 6,
        "1": 6,
        "21": 5,
        "17": 5,
        "23": 4,
        "16": 4,
        "24": 4,
        "5": 4,
        "3": 4,
        "7": 3,
        "10": 3,
        "2": 2,
        "8": 2,
        "30": 1
      }
    },
    "deg": {
      "total_degs_tested": 700,
      "significant_degs": 307,
      "n_celltypes": 7,
      "top_upregulated": [
        {
          "names": "ACACB",
          "cell_type": "Endocrine cells",
          "logfoldchanges": 2.1384003162384033
        },
        {
          "names": "ZBTB16",
          "cell_type": "Endocrine cells",
          "logfoldchanges": 2.1326818466186523
        },
        {
          "names": "FKBP5",
          "cell_type": "Endocrine cells",
          "logfoldchanges": 2.052577495574951
        },
        {
          "names": "PTPRN2",
          "cell_type": "Endocrine cells",
          "logfoldchanges": 1.9052554368972778
        },
        {
          "names": "RPL37A",
          "cell_type": "Acinar cells",
          "logfoldchanges": 1.8398898839950562
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 63,
      "kegg_pathways_found": 56,
      "celltypes_analyzed": 7
    },
    "toppgene": {
      "celltypes_analyzed": 7,
      "total_enrichments": 154
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 70
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 0,
      "top_diseases": []
    }
  }
}