{
  "data_id": "sys05tis06",
  "generated_at": "2026-02-24T09:54:48.120446",
  "analyses": {
    "cellchat": {
      "total_interactions": 3802,
      "unique_pathways": 27,
      "top_pathway": "CXCL",
      "top_source": "Endothelial cells",
      "top_target": "Dendritic cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 923,
      "top_tfs": {
        "HNF4A": 101,
        "FOS": 80,
        "JUN": 73,
        "GATA4": 67,
        "FOXA1": 64,
        "TCF7": 64,
        "GATA3": 63,
        "SOX9": 57,
        "BATF": 50,
        "CEBPB": 48
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
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        "18": 1,
        "23": 1,
        "21": 1,
        "8": 1,
        "12": 1,
        "14": 1,
        "7": 1,
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        "3": 1,
        "15": 1,
        "20": 1,
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        "25": 1,
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        "22": 1,
        "11": 1
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    },
    "deg": {
      "total_degs_tested": 1500,
      "significant_degs": 1401,
      "n_celltypes": 15,
      "top_upregulated": [
        {
          "names": "JCHAIN",
          "cell_type": "Plasma B cells",
          "logfoldchanges": 11.625110626220703
        },
        {
          "names": "PLVAP",
          "cell_type": "Endothelial cells",
          "logfoldchanges": 11.338016510009766
        },
        {
          "names": "FABP4",
          "cell_type": "Endothelial cells",
          "logfoldchanges": 10.666168212890625
        },
        {
          "names": "SPARCL1",
          "cell_type": "Fibroblasts",
          "logfoldchanges": 10.398118019104004
        },
        {
          "names": "MGP",
          "cell_type": "Fibroblasts",
          "logfoldchanges": 10.057717323303223
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 135,
      "kegg_pathways_found": 120,
      "celltypes_analyzed": 15
    },
    "toppgene": {
      "celltypes_analyzed": 15,
      "total_enrichments": 330
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 213
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 18,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Cardiovascular disease",
        "Alzheimer disease",
        "Alzheimer disease",
        "Multiple sclerosis"
      ]
    }
  }
}