{
  "data_id": "sys05tis07",
  "generated_at": "2026-02-24T09:55:06.226881",
  "analyses": {
    "cellchat": {
      "total_interactions": 8488,
      "unique_pathways": 27,
      "top_pathway": "CXCL",
      "top_source": "Fibroblasts",
      "top_target": "B cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 841,
      "top_tfs": {
        "EGR1": 119,
        "FOS": 73,
        "CEBPB": 71,
        "JUN": 66,
        "SOX9": 62,
        "FOXA1": 61,
        "HNF4A": 46,
        "TCF7": 43,
        "IRF1": 39,
        "IRF4": 38
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
        "9": 1964,
        "8": 3,
        "4": 2,
        "7": 2,
        "5": 2,
        "6": 2,
        "3": 2,
        "29": 1,
        "10": 1,
        "13": 1,
        "19": 1,
        "1": 1,
        "25": 1,
        "23": 1,
        "20": 1,
        "21": 1,
        "16": 1,
        "28": 1,
        "14": 1,
        "30": 1,
        "17": 1,
        "15": 1,
        "22": 1,
        "12": 1,
        "18": 1,
        "26": 1,
        "2": 1,
        "27": 1,
        "11": 1,
        "24": 1
      }
    },
    "deg": {
      "total_degs_tested": 2000,
      "significant_degs": 1999,
      "n_celltypes": 20,
      "top_upregulated": [
        {
          "names": "C1QC",
          "cell_type": "Macrophages",
          "logfoldchanges": 9.585095405578613
        },
        {
          "names": "CDH19",
          "cell_type": "Enteric glial cells",
          "logfoldchanges": 9.478918075561523
        },
        {
          "names": "C1QA",
          "cell_type": "Macrophages",
          "logfoldchanges": 9.46019172668457
        },
        {
          "names": "MSR1",
          "cell_type": "Macrophages",
          "logfoldchanges": 9.433146476745605
        },
        {
          "names": "CHL1",
          "cell_type": "Enteric glial cells",
          "logfoldchanges": 9.43099308013916
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 180,
      "kegg_pathways_found": 160,
      "celltypes_analyzed": 20
    },
    "toppgene": {
      "celltypes_analyzed": 20,
      "total_enrichments": 440
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 283
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 22,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Alzheimer disease",
        "Rheumatoid arthritis",
        "Multiple sclerosis",
        "Rheumatoid arthritis"
      ]
    }
  }
}