{
  "data_id": "sys06tis01",
  "generated_at": "2026-02-24T09:56:11.394997",
  "analyses": {
    "cellchat": {
      "total_interactions": 2561,
      "unique_pathways": 27,
      "top_pathway": "IGF",
      "top_source": "Macrophages",
      "top_target": "Sertoli cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 110,
      "top_tfs": {
        "GATA4": 40,
        "RUNX2": 31,
        "SOX9": 21,
        "STAT3": 6,
        "CEBPB": 5,
        "RUNX1": 3,
        "RB1": 2,
        "TP53": 1,
        "JUN": 1
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
        "12": 1964,
        "10": 4,
        "1": 2,
        "3": 2,
        "5": 2,
        "7": 2,
        "19": 1,
        "22": 1,
        "11": 1,
        "24": 1,
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        "27": 1,
        "29": 1,
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        "20": 1,
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        "21": 1
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    },
    "deg": {
      "total_degs_tested": 1100,
      "significant_degs": 1088,
      "n_celltypes": 11,
      "top_upregulated": [
        {
          "names": "CLEC7A",
          "cell_type": "Macrophages",
          "logfoldchanges": 8.732646942138672
        },
        {
          "names": "PAX8",
          "cell_type": "Efferent ductule epithelial cells",
          "logfoldchanges": 8.364831924438477
        },
        {
          "names": "C1QC",
          "cell_type": "Macrophages",
          "logfoldchanges": 8.253341674804688
        },
        {
          "names": "F13A1",
          "cell_type": "Macrophages",
          "logfoldchanges": 8.226444244384766
        },
        {
          "names": "ITGAD",
          "cell_type": "Macrophages",
          "logfoldchanges": 8.103939056396484
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 99,
      "kegg_pathways_found": 88,
      "celltypes_analyzed": 11
    },
    "toppgene": {
      "celltypes_analyzed": 11,
      "total_enrichments": 242
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 157
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 8,
      "top_diseases": [
        "Autism spectrum disorder",
        "Asthma",
        "Cardiovascular disease",
        "Parkinson disease",
        "Breast cancer"
      ]
    }
  }
}