{
  "data_id": "sys06tis02",
  "generated_at": "2026-02-24T09:56:11.136247",
  "analyses": {
    "cellchat": {
      "total_interactions": 2319,
      "unique_pathways": 26,
      "top_pathway": "IGF",
      "top_source": "Macrophages",
      "top_target": "Endothelial cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 100,
      "top_tfs": {
        "RUNX2": 24,
        "GATA4": 22,
        "RB1": 11,
        "RUNX1": 11,
        "FOXA2": 9,
        "LEF1": 8,
        "JUN": 8,
        "GATA3": 4,
        "CEBPA": 1,
        "IRF4": 1
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
        "8": 1967,
        "6": 2,
        "3": 2,
        "4": 2,
        "7": 2,
        "22": 1,
        "9": 1,
        "11": 1,
        "16": 1,
        "25": 1,
        "30": 1,
        "1": 1,
        "26": 1,
        "14": 1,
        "19": 1,
        "13": 1,
        "15": 1,
        "27": 1,
        "17": 1,
        "28": 1,
        "29": 1,
        "2": 1,
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        "18": 1,
        "10": 1,
        "12": 1,
        "21": 1,
        "24": 1,
        "23": 1,
        "5": 1
      }
    },
    "deg": {
      "total_degs_tested": 1200,
      "significant_degs": 1123,
      "n_celltypes": 12,
      "top_upregulated": [
        {
          "names": "GYS2",
          "cell_type": "Adipocytes",
          "logfoldchanges": 10.836036682128906
        },
        {
          "names": "FABP4",
          "cell_type": "Adipocytes",
          "logfoldchanges": 10.406791687011719
        },
        {
          "names": "PLIN1",
          "cell_type": "Adipocytes",
          "logfoldchanges": 9.938669204711914
        },
        {
          "names": "CIDEC",
          "cell_type": "Adipocytes",
          "logfoldchanges": 9.541138648986816
        },
        {
          "names": "PPARG",
          "cell_type": "Adipocytes",
          "logfoldchanges": 9.335370063781738
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 108,
      "kegg_pathways_found": 96,
      "celltypes_analyzed": 12
    },
    "toppgene": {
      "celltypes_analyzed": 12,
      "total_enrichments": 264
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 174
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 10,
      "top_diseases": [
        "Autism spectrum disorder",
        "Multiple sclerosis",
        "Systemic lupus erythematosus",
        "Autism spectrum disorder",
        "Alzheimer disease"
      ]
    }
  }
}