{
  "data_id": "sys09tis01",
  "generated_at": "2026-02-24T09:57:52.974997",
  "analyses": {
    "cellchat": {
      "total_interactions": 2551,
      "unique_pathways": 25,
      "top_pathway": "KIT",
      "top_source": "Podocytes",
      "top_target": "Intercalated cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 93,
      "top_tfs": {
        "HNF4A": 42,
        "GATA3": 34,
        "RUNX1": 7,
        "FOS": 2,
        "RB1": 2,
        "GATA2": 2,
        "LEF1": 2,
        "IRF4": 1,
        "BATF": 1
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
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        "9": 3,
        "8": 2,
        "1": 2,
        "7": 2,
        "5": 2,
        "6": 2,
        "3": 1,
        "13": 1,
        "16": 1,
        "14": 1,
        "15": 1,
        "29": 1,
        "24": 1,
        "22": 1,
        "26": 1,
        "23": 1,
        "18": 1,
        "12": 1,
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        "2": 1,
        "4": 1,
        "11": 1
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    },
    "deg": {
      "total_degs_tested": 1400,
      "significant_degs": 1269,
      "n_celltypes": 13,
      "top_upregulated": [
        {
          "names": "NPHS1",
          "cell_type": "Podocytes",
          "logfoldchanges": 11.120914459228516
        },
        {
          "names": "CLEC4A",
          "cell_type": "Podocytes",
          "logfoldchanges": 10.755902290344238
        },
        {
          "names": "MS4A1",
          "cell_type": "B cells",
          "logfoldchanges": 10.423532485961914
        },
        {
          "names": "WT1",
          "cell_type": "Podocytes",
          "logfoldchanges": 10.262639999389648
        },
        {
          "names": "PTPRQ",
          "cell_type": "Podocytes",
          "logfoldchanges": 10.146120071411133
        }
      ]
    },
    "enrichment": {
      "go_terms_found": 117,
      "kegg_pathways_found": 104,
      "celltypes_analyzed": 13
    },
    "toppgene": {
      "celltypes_analyzed": 13,
      "total_enrichments": 286
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 187
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 10,
      "top_diseases": [
        "Systemic lupus erythematosus",
        "Alzheimer disease",
        "Rheumatoid arthritis",
        "Multiple sclerosis",
        "Systemic lupus erythematosus"
      ]
    }
  }
}