{
  "data_id": "sys09tis02",
  "generated_at": "2026-02-24T09:58:40.138699",
  "analyses": {
    "cellchat": {
      "total_interactions": 1483,
      "unique_pathways": 26,
      "top_pathway": "IGF",
      "top_source": "Macrophages",
      "top_target": "DN T cells"
    },
    "grn": {
      "total_tfs_analyzed": 90,
      "total_tf_target_pairs": 151,
      "top_tfs": {
        "GATA3": 48,
        "RUNX1": 47,
        "FOXA1": 22,
        "GATA2": 16,
        "RUNX2": 15,
        "LEF1": 3
      }
    },
    "coexp": {
      "n_modules": 30,
      "n_genes_analyzed": 2000,
      "module_sizes": {
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        "6": 3,
        "4": 2,
        "8": 2,
        "10": 2,
        "5": 2,
        "3": 2,
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        "1": 1,
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        "26": 1,
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        "14": 1,
        "25": 1,
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    },
    "deg": {
      "total_degs_tested": 900,
      "significant_degs": 898,
      "n_celltypes": 9,
      "top_upregulated": [
        {
          "names": "CENPE",
          "cell_type": "Cycling urothelial cells",
          "logfoldchanges": 9.664569854736328
        },
        {
          "names": "TOP2A",
          "cell_type": "Cycling urothelial cells",
          "logfoldchanges": 9.520734786987305
        },
        {
          "names": "ADTRP",
          "cell_type": "Adipocytes",
          "logfoldchanges": 9.415960311889648
        },
        {
          "names": "GYS2",
          "cell_type": "Adipocytes",
          "logfoldchanges": 9.0089693069458
        },
        {
          "names": "PLIN1",
          "cell_type": "Adipocytes",
          "logfoldchanges": 8.715081214904785
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      ]
    },
    "enrichment": {
      "go_terms_found": 81,
      "kegg_pathways_found": 72,
      "celltypes_analyzed": 9
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    "toppgene": {
      "celltypes_analyzed": 9,
      "total_enrichments": 198
    },
    "motif": {
      "motifs_tested": 15,
      "significant_enrichments": 130
    },
    "disease": {
      "diseases_tested": 15,
      "significant_associations": 9,
      "top_diseases": [
        "Breast cancer",
        "Multiple sclerosis",
        "Autism spectrum disorder",
        "Autism spectrum disorder",
        "Obesity"
      ]
    }
  }
}