{
  "analyses": {
    "age_association": {
      "reason_code": "age_metadata_absent",
      "status": "not_computed"
    },
    "cellchat": {
      "reason_code": "disabled_cross_tissue",
      "status": "not_computed"
    },
    "coexpression": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP452",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Exploratory expression-correlation modules.",
      "method_status": "validated_exploratory",
      "module_sizes": {
        "1": 2,
        "10": 3,
        "11": 4,
        "12": 3,
        "13": 2,
        "14": 7,
        "15": 7,
        "16": 3,
        "17": 2,
        "18": 10,
        "19": 5,
        "2": 2,
        "20": 10,
        "21": 2,
        "22": 4,
        "23": 5,
        "24": 6,
        "25": 7,
        "26": 1889,
        "27": 1,
        "28": 1,
        "29": 1,
        "3": 1,
        "30": 1,
        "4": 3,
        "5": 4,
        "6": 7,
        "7": 4,
        "8": 3,
        "9": 1
      },
      "n_genes_analyzed": 2000,
      "n_modules": 30,
      "sampling": {
        "n_cells": 1827,
        "seed": 20260808,
        "source_cells": 15426,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "validated_exploratory": true
    },
    "deg": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP452",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Descriptive cell-level marker ranking; not donor-level inference.",
      "method_status": "validated_exploratory",
      "n_celltypes": 8,
      "sampling": {
        "n_cells": 1827,
        "seed": 20260808,
        "source_cells": 15426,
        "strategy": "tissue_cell_type_stratified"
      },
      "significant_degs": 627,
      "status": "validated_exploratory",
      "total_degs_tested": 800,
      "validated_exploratory": true
    },
    "disease": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP452",
      "diseases_tested": 15,
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated disease-gene overlap; descriptive only.",
      "method_status": "validated_exploratory",
      "sampling": {
        "n_cells": 1827,
        "seed": 20260808,
        "source_cells": 15426,
        "strategy": "tissue_cell_type_stratified"
      },
      "significant_associations": 6,
      "status": "validated_exploratory",
      "top_diseases": [
        "Autism spectrum disorder",
        "Systemic lupus erythematosus",
        "Autism spectrum disorder",
        "Autism spectrum disorder",
        "Colorectal cancer"
      ],
      "validated_exploratory": true
    },
    "drug": {
      "analysis_scope": "exploratory_stratified_sample",
      "celltypes_analyzed": 8,
      "data_id": "SP452",
      "drugs_screened": 18,
      "drugs_with_targets": 16,
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated drug-target expression matching; descriptive only.",
      "method_status": "validated_exploratory",
      "sampling": {
        "n_cells": 1827,
        "seed": 20260808,
        "source_cells": 15426,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "top_drugs": [
        "Dexamethasone",
        "Cyclosporine",
        "Venetoclax",
        "Ruxolitinib",
        "Sorafenib"
      ],
      "validated_exploratory": true
    },
    "grn": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP452",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Exploratory TF-target associations; not causal inference.",
      "method_status": "validated_exploratory",
      "sampling": {
        "n_cells": 1827,
        "seed": 20260808,
        "source_cells": 15426,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "top_tfs": {
        "AHR": 73,
        "HIF1A": 15,
        "LEF1": 18,
        "NFKB1": 23,
        "PAX6": 22,
        "RUNX1": 64,
        "RUNX2": 13,
        "SOX9": 14,
        "STAT3": 19,
        "TP53": 17
      },
      "total_tf_target_pairs": 350,
      "total_tfs_analyzed": 73,
      "validated_exploratory": true
    },
    "metabolism": {
      "analysis_scope": "exploratory_stratified_sample",
      "celltypes_analyzed": 8,
      "data_id": "SP452",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated metabolic gene-set scores; descriptive only.",
      "method_status": "validated_exploratory",
      "pathways_detected": 12,
      "pathways_scored": 12,
      "sampling": {
        "n_cells": 1827,
        "seed": 20260808,
        "source_cells": 15426,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "top_pathways": [
        "Glutamine Metabolism",
        "Fatty Acid Synthesis",
        "Glycolysis",
        "TCA Cycle",
        "Fatty Acid Oxidation"
      ],
      "validated_exploratory": true
    },
    "trajectory": {
      "reason_code": "no_lineage_root",
      "status": "not_computed"
    }
  },
  "analysis_scope": "exploratory_stratified_sample",
  "data_id": "SP452",
  "generated_at": "2026-08-08T08:17:27.151709Z",
  "sample_cells": 1827,
  "sampling": {
    "n_cells": 1827,
    "seed": 20260808,
    "source_cells": 15426,
    "strategy": "tissue_cell_type_stratified"
  },
  "schema_version": 1,
  "source_cells": 15426,
  "status": "validated_exploratory",
  "validated_exploratory": true
}