{
  "analyses": {
    "age_association": {
      "reason_code": "age_metadata_absent",
      "status": "not_computed"
    },
    "cellchat": {
      "reason_code": "disabled_cross_tissue",
      "status": "not_computed"
    },
    "coexpression": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP460",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Exploratory expression-correlation modules.",
      "method_status": "validated_exploratory",
      "module_sizes": {
        "1": 3,
        "10": 7,
        "11": 6,
        "12": 3,
        "13": 4,
        "14": 6,
        "15": 7,
        "16": 4,
        "17": 12,
        "18": 6,
        "19": 2,
        "2": 3,
        "20": 7,
        "21": 9,
        "22": 8,
        "23": 14,
        "24": 5,
        "25": 16,
        "26": 4,
        "27": 1855,
        "28": 1,
        "29": 1,
        "3": 1,
        "30": 1,
        "4": 2,
        "5": 1,
        "6": 1,
        "7": 5,
        "8": 4,
        "9": 2
      },
      "n_genes_analyzed": 2000,
      "n_modules": 30,
      "sampling": {
        "n_cells": 3392,
        "seed": 20260808,
        "source_cells": 8891,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "validated_exploratory": true
    },
    "deg": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP460",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Descriptive cell-level marker ranking; not donor-level inference.",
      "method_status": "validated_exploratory",
      "n_celltypes": 17,
      "sampling": {
        "n_cells": 3392,
        "seed": 20260808,
        "source_cells": 8891,
        "strategy": "tissue_cell_type_stratified"
      },
      "significant_degs": 1146,
      "status": "validated_exploratory",
      "total_degs_tested": 1700,
      "validated_exploratory": true
    },
    "disease": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP460",
      "diseases_tested": 15,
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated disease-gene overlap; descriptive only.",
      "method_status": "validated_exploratory",
      "sampling": {
        "n_cells": 3392,
        "seed": 20260808,
        "source_cells": 8891,
        "strategy": "tissue_cell_type_stratified"
      },
      "significant_associations": 4,
      "status": "validated_exploratory",
      "top_diseases": [
        "Alzheimer disease",
        "Alzheimer disease",
        "Alzheimer disease",
        "Alzheimer disease"
      ],
      "validated_exploratory": true
    },
    "drug": {
      "analysis_scope": "exploratory_stratified_sample",
      "celltypes_analyzed": 17,
      "data_id": "SP460",
      "drugs_screened": 18,
      "drugs_with_targets": 4,
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated drug-target expression matching; descriptive only.",
      "method_status": "validated_exploratory",
      "sampling": {
        "n_cells": 3392,
        "seed": 20260808,
        "source_cells": 8891,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "top_drugs": [
        "Methotrexate",
        "Imatinib",
        "Aspirin",
        "Sorafenib"
      ],
      "validated_exploratory": true
    },
    "grn": {
      "analysis_scope": "exploratory_stratified_sample",
      "data_id": "SP460",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Exploratory TF-target associations; not causal inference.",
      "method_status": "validated_exploratory",
      "sampling": {
        "n_cells": 3392,
        "seed": 20260808,
        "source_cells": 8891,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "top_tfs": {
        "ATF3": 9,
        "EOMES": 7,
        "FOS": 26,
        "GATA2": 6,
        "NFE2L2": 12,
        "NKX2-1": 13,
        "OTX2": 16,
        "SOX11": 35,
        "SOX2": 10,
        "SPI1": 16
      },
      "total_tf_target_pairs": 189,
      "total_tfs_analyzed": 20,
      "validated_exploratory": true
    },
    "metabolism": {
      "analysis_scope": "exploratory_stratified_sample",
      "celltypes_analyzed": 17,
      "data_id": "SP460",
      "generated_at": "2026-08-08T08:17:27.151709Z",
      "independent_biological_replicates": false,
      "inferential_scope": "descriptive_cell_level",
      "interpretation": "Curated metabolic gene-set scores; descriptive only.",
      "method_status": "validated_exploratory",
      "pathways_detected": 11,
      "pathways_scored": 12,
      "sampling": {
        "n_cells": 3392,
        "seed": 20260808,
        "source_cells": 8891,
        "strategy": "tissue_cell_type_stratified"
      },
      "status": "validated_exploratory",
      "top_pathways": [
        "Pentose Phosphate",
        "Purine Metabolism",
        "Glycolysis",
        "Cholesterol Biosynthesis",
        "Urea Cycle"
      ],
      "validated_exploratory": true
    },
    "trajectory": {
      "reason_code": "no_lineage_root",
      "status": "not_computed"
    }
  },
  "analysis_scope": "exploratory_stratified_sample",
  "data_id": "SP460",
  "generated_at": "2026-08-08T08:17:27.151709Z",
  "sample_cells": 3392,
  "sampling": {
    "n_cells": 3392,
    "seed": 20260808,
    "source_cells": 8891,
    "strategy": "tissue_cell_type_stratified"
  },
  "schema_version": 1,
  "source_cells": 8891,
  "status": "validated_exploratory",
  "validated_exploratory": true
}