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2.4971868991851807, "mean": 0.023028111085295677, "name": "Other stromal cells", "pct_positive": 3.415446864215161 }, { "count": 1575, "max": 1.6059272289276123, "mean": 0.021746516227722168, "name": "Pericytes", "pct_positive": 3.6825396825396823 }, { "count": 9129, "max": 2.2623724937438965, "mean": 0.01979023404419422, "name": "Macrophages", "pct_positive": 2.683755066272319 }, { "count": 4328, "max": 1.3769919872283936, "mean": 0.00541655533015728, "name": "Cardiomyocytes", "pct_positive": 0.7393715341959335 }, { "count": 7532, "max": 1.6236684322357178, "mean": 0.0024493385571986437, "name": "Smooth muscle cells", "pct_positive": 0.34519383961763145 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "ACE", "name": "Angiotensin-Converting Enzyme", "overall": { "max": 3.1137542724609375, "mean": 0.036284126341342926, "median": 0.0, "p95": 0.0, "pct_positive": 4.119206781939725 }, "pathway": "Signal Transduction", "pmid": "16463022", "q99_positive_species": 2.4906063079833984, "source_symbol": "ACE", "symbol": "ACE", "tissue_stats": [ { "count": 23794, "max": 3.1137542724609375, "mean": 0.038802046328783035, "name": "Heart", "pct_positive": 3.4084222913339497 }, { "count": 29760, "max": 2.6501364707946777, "mean": 0.03427097946405411, "name": "Vasculature", "pct_positive": 4.6875 } ], "top_celltype": { "count": 14184, "max": 3.1137542724609375, "mean": 0.09160622954368591, "name": "Endothelial cells", "pct_positive": 8.960800902425268 }, "top_tissue": { "count": 23794, "max": 3.1137542724609375, "mean": 0.038802046328783035, "name": "Heart", "pct_positive": 3.4084222913339497 }, "vector_key": "ACE" } ], "interpretation": "Descriptive relative-expression scores only. Compare scores only within the same source species and an identical mapped gene set. Higher expression scores do not imply a pro-longevity direction, and these results do not establish causality.", "method_status": "validated_real", "schema_version": "2.0", "signature": { "coverage_status": "full", "denominator_gene_count": 15, "gene_set_id": "LACA-LONGEVITY-15-v1", "mapped_count": 15, "mapped_genes": [ "APOE", "FOXO3", "CETP", "SIRT6", "SIRT1", "SIRT3", "IGF1R", "KLOTHO", "APOC3", "IL6", "TERT", "IRS2", "TP53", "SHC1", "ACE" ], "mapping_method": "case_insensitive_exact", "missing_gene_handling": "none_missing", "missing_genes": [], "ortholog_inference": false, "score_basis": "all_curated_genes", "total_genes": 15 }, "status": "available" }