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      "pathway": "Signal Transduction",
      "pmid": "16463022",
      "q99_positive_species": 2.4906063079833984,
      "source_symbol": "ACE",
      "symbol": "ACE",
      "tissue_stats": [
        {
          "count": 2597,
          "max": 3.5432634353637695,
          "mean": 0.5586000680923462,
          "name": "Small intestine",
          "pct_positive": 28.14786291875241
        },
        {
          "count": 19036,
          "max": 3.134800910949707,
          "mean": 0.3292752504348755,
          "name": "Small Intestine",
          "pct_positive": 28.918890523219165
        },
        {
          "count": 8920,
          "max": 2.7969207763671875,
          "mean": 0.09225339442491531,
          "name": "Pancreas",
          "pct_positive": 10.134529147982063
        },
        {
          "count": 11904,
          "max": 2.503347635269165,
          "mean": 0.08116774260997772,
          "name": "Liver",
          "pct_positive": 8.803763440860216
        },
        {
          "count": 5530,
          "max": 3.134538173675537,
          "mean": 0.024310316890478134,
          "name": "Esophagus",
          "pct_positive": 1.1754068716094033
        },
        {
          "count": 22530,
          "max": 2.624727964401245,
          "mean": 0.021316267549991608,
          "name": "Salivary gland",
          "pct_positive": 2.729693741677763
        },
        {
          "count": 20234,
          "max": 2.975325584411621,
          "mean": 0.017138294875621796,
          "name": "Large Intestine",
          "pct_positive": 2.169615498665612
        },
        {
          "count": 5976,
          "max": 2.4427123069763184,
          "mean": 0.016246821731328964,
          "name": "Rectum",
          "pct_positive": 1.2717536813922357
        },
        {
          "count": 22936,
          "max": 2.476769208908081,
          "mean": 0.011530849151313305,
          "name": "Tongue",
          "pct_positive": 1.2077084059993024
        },
        {
          "count": 28043,
          "max": 2.4513890743255615,
          "mean": 0.006696655414998531,
          "name": "Stomach",
          "pct_positive": 0.7381521235245873
        }
      ],
      "top_celltype": {
        "count": 9694,
        "max": 3.5432634353637695,
        "mean": 0.7003666758537292,
        "name": "Enterocytes",
        "pct_positive": 53.50732411801115
      },
      "top_tissue": {
        "count": 2597,
        "max": 3.5432634353637695,
        "mean": 0.5586000680923462,
        "name": "Small intestine",
        "pct_positive": 28.14786291875241
      },
      "vector_key": "ACE"
    }
  ],
  "interpretation": "Descriptive relative-expression scores only. Compare scores only within the same source species and an identical mapped gene set. Higher expression scores do not imply a pro-longevity direction, and these results do not establish causality.",
  "method_status": "validated_real",
  "schema_version": "2.0",
  "signature": {
    "coverage_status": "full",
    "denominator_gene_count": 15,
    "gene_set_id": "LACA-LONGEVITY-15-v1",
    "mapped_count": 15,
    "mapped_genes": [
      "APOE",
      "FOXO3",
      "CETP",
      "SIRT6",
      "SIRT1",
      "SIRT3",
      "IGF1R",
      "KLOTHO",
      "APOC3",
      "IL6",
      "TERT",
      "IRS2",
      "TP53",
      "SHC1",
      "ACE"
    ],
    "mapping_method": "case_insensitive_exact",
    "missing_gene_handling": "none_missing",
    "missing_genes": [],
    "ortholog_inference": false,
    "score_basis": "all_curated_genes",
    "total_genes": 15
  },
  "status": "available"
}
