{
  "dataset": {
    "celltype_key": "laca_curated_celltype_v3",
    "expression": "Values are read directly from the source H5AD X matrix; the exporter applies no expression transformation.",
    "generated_at": "2026-08-07T17:18:41.105841+00:00",
    "item_id": "sys07",
    "mode": "system",
    "n_cells": 119655,
    "n_genes_in_matrix": 19739,
    "page_key": "system:SP121:sys07",
    "source_file": "SP121.h5ad",
    "sp_id": "SP121",
    "tissue_key": "Tissue"
  },
  "downloads": {
    "summary_csv": "summary.csv"
  },
  "gene_set": {
    "celltype_stats": [
      {
        "count": 1909,
        "max": 0.31199875473976135,
        "mean": 0.11612344533205032,
        "name": "Monocytes",
        "pct_positive": 99.37139863803039
      },
      {
        "count": 23737,
        "max": 0.3288303315639496,
        "mean": 0.10692811012268066,
        "name": "Macrophages",
        "pct_positive": 96.68871382230273
      },
      {
        "count": 268,
        "max": 0.2454148828983307,
        "mean": 0.10156973451375961,
        "name": "Mesothelial cells",
        "pct_positive": 99.25373134328358
      },
      {
        "count": 32911,
        "max": 0.2996058166027069,
        "mean": 0.09052575379610062,
        "name": "Fibroblasts",
        "pct_positive": 95.21436601744098
      },
      {
        "count": 10260,
        "max": 0.2865084409713745,
        "mean": 0.08666224777698517,
        "name": "Endothelial cells",
        "pct_positive": 93.13840155945418
      },
      {
        "count": 2201,
        "max": 0.23363086581230164,
        "mean": 0.07959765195846558,
        "name": "Adipocyte progenitor cells",
        "pct_positive": 87.09677419354838
      },
      {
        "count": 4658,
        "max": 0.3062604069709778,
        "mean": 0.07852639257907867,
        "name": "Smooth muscle cells",
        "pct_positive": 91.82052382996994
      },
      {
        "count": 11724,
        "max": 0.2304115891456604,
        "mean": 0.06430374085903168,
        "name": "Adipocytes",
        "pct_positive": 92.47697031729784
      },
      {
        "count": 15287,
        "max": 0.23139594495296478,
        "mean": 0.05652736499905586,
        "name": "B cells",
        "pct_positive": 88.36266108458167
      },
      {
        "count": 14475,
        "max": 0.2588246464729309,
        "mean": 0.05492864549160004,
        "name": "Natural killer T cells",
        "pct_positive": 84.69775474956822
      },
      {
        "count": 554,
        "max": 0.16903968155384064,
        "mean": 0.034100186079740524,
        "name": "Follicular cells",
        "pct_positive": 73.46570397111914
      },
      {
        "count": 1671,
        "max": 0.18247194588184357,
        "mean": 0.029597781598567963,
        "name": "Dendritic cells",
        "pct_positive": 61.759425493716336
      }
    ],
    "coverage_status": "full",
    "denominator_gene_count": 15,
    "mapped_count": 15,
    "method": {
      "alias": {
        "KLOTHO": "KL"
      },
      "calibration": [
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "APOE",
          "positive_n": 245743,
          "positive_pct": 19.716776385729702,
          "q99_positive": 4.913139343261719,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "APOE",
          "symbol": "APOE"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "FOXO3",
          "positive_n": 727901,
          "positive_pct": 58.401912762312804,
          "q99_positive": 3.682433843612671,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "FOXO3",
          "symbol": "FOXO3"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "CETP",
          "positive_n": 15958,
          "positive_pct": 1.2803632964661236,
          "q99_positive": 2.8351151943206787,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "CETP",
          "symbol": "CETP"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "SIRT6",
          "positive_n": 94936,
          "positive_pct": 7.617030324182723,
          "q99_positive": 2.0462136268615723,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "SIRT6",
          "symbol": "SIRT6"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "SIRT1",
          "positive_n": 314865,
          "positive_pct": 25.262663826407195,
          "q99_positive": 2.3554694652557373,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "SIRT1",
          "symbol": "SIRT1"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "SIRT3",
          "positive_n": 125788,
          "positive_pct": 10.09238866624143,
          "q99_positive": 2.101539373397827,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "SIRT3",
          "symbol": "SIRT3"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "IGF1R",
          "positive_n": 574396,
          "positive_pct": 46.08569720747935,
          "q99_positive": 3.4061527252197266,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "IGF1R",
          "symbol": "IGF1R"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "KL",
          "positive_n": 25561,
          "positive_pct": 2.0508438539272205,
          "q99_positive": 2.4546902179718018,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "KL",
          "symbol": "KLOTHO"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "APOC3",
          "positive_n": 22296,
          "positive_pct": 1.7888820690568172,
          "q99_positive": 6.765168190002441,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "APOC3",
          "symbol": "APOC3"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "IL6",
          "positive_n": 69252,
          "positive_pct": 5.556317772081212,
          "q99_positive": 4.358819484710693,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "IL6",
          "symbol": "IL6"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "TERT",
          "positive_n": 2751,
          "positive_pct": 0.22072185916645606,
          "q99_positive": 1.945739507675171,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "TERT",
          "symbol": "TERT"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "IRS2",
          "positive_n": 426152,
          "positive_pct": 34.19158914122268,
          "q99_positive": 3.3082995414733887,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "IRS2",
          "symbol": "IRS2"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "TP53",
          "positive_n": 170394,
          "positive_pct": 13.671276070813926,
          "q99_positive": 2.170886993408203,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "TP53",
          "symbol": "TP53"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "SHC1",
          "positive_n": 172211,
          "positive_pct": 13.817060010510565,
          "q99_positive": 2.1945977210998535,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "SHC1",
          "symbol": "SHC1"
        },
        {
          "fallback_reason": null,
          "fallback_used": false,
          "matrix_symbol": "ACE",
          "positive_n": 40647,
          "positive_pct": 3.261243696669916,
          "q99_positive": 2.4906063079833984,
          "quantile_method": "linear",
          "reference_n_cells": 1246365,
          "source_symbol": "ACE",
          "symbol": "ACE"
        }
      ],
      "causal_interpretation": false,
      "comparison_scope": "same_source_species_and_identical_mapped_gene_set_only",
      "coverage_status": "full",
      "curated_genes": [
        "APOE",
        "FOXO3",
        "CETP",
        "SIRT6",
        "SIRT1",
        "SIRT3",
        "IGF1R",
        "KLOTHO",
        "APOC3",
        "IL6",
        "TERT",
        "IRS2",
        "TP53",
        "SHC1",
        "ACE"
      ],
      "denominator_gene_count": 15,
      "directionality": "relative_expression_not_pro_longevity_direction",
      "formula": "mean(clip(matrix_value / species_positive_q99, 0, 1))",
      "gene_set_id": "LACA-LONGEVITY-15-v1",
      "genes": [
        "APOE",
        "FOXO3",
        "CETP",
        "SIRT6",
        "SIRT1",
        "SIRT3",
        "IGF1R",
        "KLOTHO",
        "APOC3",
        "IL6",
        "TERT",
        "IRS2",
        "TP53",
        "SHC1",
        "ACE"
      ],
      "missing_gene_handling": "not_applicable_all_curated_genes_mapped",
      "name": "Equal-weight species-calibrated relative expression score",
      "normalization": "Each mapped gene is scaled by its 99th percentile among positive cells in the complete source-species H5AD.",
      "range": [
        0,
        1
      ],
      "score_basis": "all_curated_genes"
    },
    "missing_gene_handling": "none_missing",
    "missing_genes": [],
    "name": "Longevity Gene Set",
    "overall": {
      "max": 0.3288303315639496,
      "mean": 0.08088206499814987,
      "mean_genes_detected": 2.820567464794618,
      "median": 0.07756010442972183,
      "median_genes_detected": 3.0,
      "p95": 0.16684842109680176,
      "pct_any_gene": 92.13906648280474,
      "pct_positive": 92.13906648280474
    },
    "pathway": "Curated 15-gene signature",
    "score_basis": "all_curated_genes",
    "symbol": "LONGEVITY_SET",
    "tissue_stats": [
      {
        "count": 117207,
        "max": 0.3288303315639496,
        "mean": 0.08186603337526321,
        "name": "Adipose",
        "pct_positive": 92.6736457720102
      },
      {
        "count": 2448,
        "max": 0.21266157925128937,
        "mean": 0.03377096727490425,
        "name": "Thyroid gland",
        "pct_positive": 66.54411764705883
      }
    ],
    "top_celltype": {
      "count": 1909,
      "max": 0.31199875473976135,
      "mean": 0.11612344533205032,
      "name": "Monocytes",
      "pct_positive": 99.37139863803039
    },
    "top_tissue": {
      "count": 117207,
      "max": 0.3288303315639496,
      "mean": 0.08186603337526321,
      "name": "Adipose",
      "pct_positive": 92.6736457720102
    },
    "total_genes": 15,
    "vector_key": "LONGEVITY_SET"
  },
  "genes": [
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "APOE",
        "positive_n": 245743,
        "positive_pct": 19.716776385729702,
        "q99_positive": 4.913139343261719,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "APOE",
        "symbol": "APOE"
      },
      "celltype_stats": [
        {
          "count": 268,
          "max": 4.473008155822754,
          "mean": 1.6604291200637817,
          "name": "Mesothelial cells",
          "pct_positive": 79.8507462686567
        },
        {
          "count": 32911,
          "max": 5.751489162445068,
          "mean": 1.2566957473754883,
          "name": "Fibroblasts",
          "pct_positive": 51.33238127069977
        },
        {
          "count": 4658,
          "max": 5.682126998901367,
          "mean": 0.7070853114128113,
          "name": "Smooth muscle cells",
          "pct_positive": 39.09403177329326
        },
        {
          "count": 23737,
          "max": 5.258616924285889,
          "mean": 0.6181884407997131,
          "name": "Macrophages",
          "pct_positive": 37.92391624889413
        },
        {
          "count": 2201,
          "max": 4.464651584625244,
          "mean": 0.41006508469581604,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 26.715129486597
        },
        {
          "count": 10260,
          "max": 4.674269676208496,
          "mean": 0.38925132155418396,
          "name": "Endothelial cells",
          "pct_positive": 29.96101364522417
        },
        {
          "count": 1909,
          "max": 4.390664100646973,
          "mean": 0.37610387802124023,
          "name": "Monocytes",
          "pct_positive": 25.0392875851231
        },
        {
          "count": 1671,
          "max": 6.155892848968506,
          "mean": 0.28505468368530273,
          "name": "Dendritic cells",
          "pct_positive": 15.200478755236386
        },
        {
          "count": 14475,
          "max": 3.6748580932617188,
          "mean": 0.168733611702919,
          "name": "Natural killer T cells",
          "pct_positive": 14.756476683937825
        },
        {
          "count": 11724,
          "max": 3.7227494716644287,
          "mean": 0.16196271777153015,
          "name": "Adipocytes",
          "pct_positive": 13.263391334015695
        },
        {
          "count": 15287,
          "max": 5.021917343139648,
          "mean": 0.16031260788440704,
          "name": "B cells",
          "pct_positive": 14.450186432916857
        },
        {
          "count": 554,
          "max": 3.0589215755462646,
          "mean": 0.045574262738227844,
          "name": "Follicular cells",
          "pct_positive": 5.776173285198556
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "APOE",
      "name": "Apolipoprotein E",
      "overall": {
        "max": 6.155892848968506,
        "mean": 0.607408344745636,
        "median": 0.0,
        "p95": 3.3464694023132324,
        "pct_positive": 31.972755003969745
      },
      "pathway": "Lipid Metabolism",
      "pmid": "8136829",
      "q99_positive_species": 4.913139343261719,
      "source_symbol": "APOE",
      "symbol": "APOE",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 5.751489162445068,
          "mean": 0.6155004501342773,
          "name": "Adipose",
          "pct_positive": 32.37861219893009
        },
        {
          "count": 2448,
          "max": 6.155892848968506,
          "mean": 0.21997125446796417,
          "name": "Thyroid gland",
          "pct_positive": 12.540849673202615
        }
      ],
      "top_celltype": {
        "count": 268,
        "max": 4.473008155822754,
        "mean": 1.6604291200637817,
        "name": "Mesothelial cells",
        "pct_positive": 79.8507462686567
      },
      "top_tissue": {
        "count": 117207,
        "max": 5.751489162445068,
        "mean": 0.6155004501342773,
        "name": "Adipose",
        "pct_positive": 32.37861219893009
      },
      "vector_key": "APOE"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "FOXO3",
        "positive_n": 727901,
        "positive_pct": 58.401912762312804,
        "q99_positive": 3.682433843612671,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "FOXO3",
        "symbol": "FOXO3"
      },
      "celltype_stats": [
        {
          "count": 23737,
          "max": 5.053280830383301,
          "mean": 2.0011019706726074,
          "name": "Macrophages",
          "pct_positive": 87.97657665248346
        },
        {
          "count": 1909,
          "max": 4.48660945892334,
          "mean": 1.761115312576294,
          "name": "Monocytes",
          "pct_positive": 84.80880041906758
        },
        {
          "count": 2201,
          "max": 5.339219093322754,
          "mean": 1.17184579372406,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 58.655156746933216
        },
        {
          "count": 32911,
          "max": 4.361815929412842,
          "mean": 1.1667827367782593,
          "name": "Fibroblasts",
          "pct_positive": 74.95366290905775
        },
        {
          "count": 11724,
          "max": 3.919302463531494,
          "mean": 1.1051316261291504,
          "name": "Adipocytes",
          "pct_positive": 68.27874445581713
        },
        {
          "count": 268,
          "max": 3.6406664848327637,
          "mean": 1.0921599864959717,
          "name": "Mesothelial cells",
          "pct_positive": 81.71641791044776
        },
        {
          "count": 10260,
          "max": 4.065863132476807,
          "mean": 0.9897406697273254,
          "name": "Endothelial cells",
          "pct_positive": 61.81286549707602
        },
        {
          "count": 4658,
          "max": 4.467933177947998,
          "mean": 0.9728684425354004,
          "name": "Smooth muscle cells",
          "pct_positive": 63.41777586947188
        },
        {
          "count": 15287,
          "max": 3.956270694732666,
          "mean": 0.8705624341964722,
          "name": "B cells",
          "pct_positive": 56.97651599398181
        },
        {
          "count": 14475,
          "max": 4.606053829193115,
          "mean": 0.7809640765190125,
          "name": "Natural killer T cells",
          "pct_positive": 50.32124352331606
        },
        {
          "count": 554,
          "max": 3.681720733642578,
          "mean": 0.4121450185775757,
          "name": "Follicular cells",
          "pct_positive": 40.61371841155235
        },
        {
          "count": 1671,
          "max": 3.10455322265625,
          "mean": 0.2511381208896637,
          "name": "Dendritic cells",
          "pct_positive": 22.860562537402753
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "FOXO3",
      "name": "Forkhead Box O3",
      "overall": {
        "max": 5.339219093322754,
        "mean": 1.2121323347091675,
        "median": 1.2777793407440186,
        "p95": 2.9037623405456543,
        "pct_positive": 69.01675650829469
      },
      "pathway": "Insulin/IGF-1 Signaling",
      "pmid": "18765803",
      "q99_positive_species": 3.682433843612671,
      "source_symbol": "FOXO3",
      "symbol": "FOXO3",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 5.339219093322754,
          "mean": 1.2306175231933594,
          "name": "Adipose",
          "pct_positive": 69.84139172575017
        },
        {
          "count": 2448,
          "max": 3.681720733642578,
          "mean": 0.3270840048789978,
          "name": "Thyroid gland",
          "pct_positive": 29.534313725490197
        }
      ],
      "top_celltype": {
        "count": 23737,
        "max": 5.053280830383301,
        "mean": 2.0011019706726074,
        "name": "Macrophages",
        "pct_positive": 87.97657665248346
      },
      "top_tissue": {
        "count": 117207,
        "max": 5.339219093322754,
        "mean": 1.2306175231933594,
        "name": "Adipose",
        "pct_positive": 69.84139172575017
      },
      "vector_key": "FOXO3"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "CETP",
        "positive_n": 15958,
        "positive_pct": 1.2803632964661236,
        "q99_positive": 2.8351151943206787,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "CETP",
        "symbol": "CETP"
      },
      "celltype_stats": [
        {
          "count": 10260,
          "max": 4.310443878173828,
          "mean": 0.18393653631210327,
          "name": "Endothelial cells",
          "pct_positive": 13.538011695906432
        },
        {
          "count": 23737,
          "max": 3.433314323425293,
          "mean": 0.07425259053707123,
          "name": "Macrophages",
          "pct_positive": 6.921683447781944
        },
        {
          "count": 2201,
          "max": 1.8058557510375977,
          "mean": 0.017633743584156036,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 1.6810540663334848
        },
        {
          "count": 4658,
          "max": 2.0927674770355225,
          "mean": 0.013712712563574314,
          "name": "Smooth muscle cells",
          "pct_positive": 1.2022327179046801
        },
        {
          "count": 32911,
          "max": 2.518108367919922,
          "mean": 0.00994561892002821,
          "name": "Fibroblasts",
          "pct_positive": 1.2974385463826683
        },
        {
          "count": 15287,
          "max": 1.7163399457931519,
          "mean": 0.006373986601829529,
          "name": "B cells",
          "pct_positive": 0.5952770327729443
        },
        {
          "count": 1909,
          "max": 1.5486419200897217,
          "mean": 0.0061575872823596,
          "name": "Monocytes",
          "pct_positive": 0.5238344683080147
        },
        {
          "count": 14475,
          "max": 2.803109884262085,
          "mean": 0.005971317645162344,
          "name": "Natural killer T cells",
          "pct_positive": 0.5457685664939551
        },
        {
          "count": 11724,
          "max": 1.699511170387268,
          "mean": 0.004172173328697681,
          "name": "Adipocytes",
          "pct_positive": 0.4179460934834528
        },
        {
          "count": 268,
          "max": 0.5390560030937195,
          "mean": 0.002011402975767851,
          "name": "Mesothelial cells",
          "pct_positive": 0.3731343283582089
        },
        {
          "count": 1671,
          "max": 1.164279580116272,
          "mean": 0.001173707889392972,
          "name": "Dendritic cells",
          "pct_positive": 0.17953321364452424
        },
        {
          "count": 554,
          "max": 0.0,
          "mean": 0.0,
          "name": "Follicular cells",
          "pct_positive": 0.0
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "CETP",
      "name": "Cholesteryl Ester Transfer Protein",
      "overall": {
        "max": 4.310443878173828,
        "mean": 0.03616039827466011,
        "median": 0.0,
        "p95": 0.0,
        "pct_positive": 3.163261042162885
      },
      "pathway": "Lipid Metabolism",
      "pmid": "14559957",
      "q99_positive_species": 2.8351151943206787,
      "source_symbol": "CETP",
      "symbol": "CETP",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 4.310443878173828,
          "mean": 0.03685824200510979,
          "name": "Adipose",
          "pct_positive": 3.2233569667340687
        },
        {
          "count": 2448,
          "max": 2.073687791824341,
          "mean": 0.0027484113816171885,
          "name": "Thyroid gland",
          "pct_positive": 0.28594771241830064
        }
      ],
      "top_celltype": {
        "count": 10260,
        "max": 4.310443878173828,
        "mean": 0.18393653631210327,
        "name": "Endothelial cells",
        "pct_positive": 13.538011695906432
      },
      "top_tissue": {
        "count": 117207,
        "max": 4.310443878173828,
        "mean": 0.03685824200510979,
        "name": "Adipose",
        "pct_positive": 3.2233569667340687
      },
      "vector_key": "CETP"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "SIRT6",
        "positive_n": 94936,
        "positive_pct": 7.617030324182723,
        "q99_positive": 2.0462136268615723,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "SIRT6",
        "symbol": "SIRT6"
      },
      "celltype_stats": [
        {
          "count": 1671,
          "max": 2.3173880577087402,
          "mean": 0.06612560898065567,
          "name": "Dendritic cells",
          "pct_positive": 7.5403949730700175
        },
        {
          "count": 554,
          "max": 2.2115745544433594,
          "mean": 0.06431891024112701,
          "name": "Follicular cells",
          "pct_positive": 10.288808664259928
        },
        {
          "count": 268,
          "max": 1.1873626708984375,
          "mean": 0.062081336975097656,
          "name": "Mesothelial cells",
          "pct_positive": 10.074626865671641
        },
        {
          "count": 23737,
          "max": 2.641754388809204,
          "mean": 0.05171351507306099,
          "name": "Macrophages",
          "pct_positive": 6.934321944643383
        },
        {
          "count": 15287,
          "max": 2.079179048538208,
          "mean": 0.04835040494799614,
          "name": "B cells",
          "pct_positive": 4.664093674363839
        },
        {
          "count": 10260,
          "max": 2.338270425796509,
          "mean": 0.045846156775951385,
          "name": "Endothelial cells",
          "pct_positive": 5.701754385964912
        },
        {
          "count": 32911,
          "max": 2.64905047416687,
          "mean": 0.04541373997926712,
          "name": "Fibroblasts",
          "pct_positive": 6.997660356719637
        },
        {
          "count": 14475,
          "max": 2.5419981479644775,
          "mean": 0.041255123913288116,
          "name": "Natural killer T cells",
          "pct_positive": 3.730569948186528
        },
        {
          "count": 4658,
          "max": 2.3879549503326416,
          "mean": 0.038320865482091904,
          "name": "Smooth muscle cells",
          "pct_positive": 4.658651781880636
        },
        {
          "count": 1909,
          "max": 1.5065711736679077,
          "mean": 0.03818512707948685,
          "name": "Monocytes",
          "pct_positive": 3.823991618648507
        },
        {
          "count": 2201,
          "max": 2.408876419067383,
          "mean": 0.02726973220705986,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 2.680599727396638
        },
        {
          "count": 11724,
          "max": 2.367546558380127,
          "mean": 0.024402020499110222,
          "name": "Adipocytes",
          "pct_positive": 2.320027294438758
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "SIRT6",
      "name": "Sirtuin 6",
      "overall": {
        "max": 2.64905047416687,
        "mean": 0.04420281574130058,
        "median": 0.0,
        "p95": 0.36449092626571655,
        "pct_positive": 5.5309013413564
      },
      "pathway": "Sirtuin Family",
      "pmid": "36215696",
      "q99_positive_species": 2.0462136268615723,
      "source_symbol": "SIRT6",
      "symbol": "SIRT6",
      "tissue_stats": [
        {
          "count": 2448,
          "max": 2.3173880577087402,
          "mean": 0.06773356348276138,
          "name": "Thyroid gland",
          "pct_positive": 8.57843137254902
        },
        {
          "count": 117207,
          "max": 2.64905047416687,
          "mean": 0.0437113456428051,
          "name": "Adipose",
          "pct_positive": 5.467250249558473
        }
      ],
      "top_celltype": {
        "count": 1671,
        "max": 2.3173880577087402,
        "mean": 0.06612560898065567,
        "name": "Dendritic cells",
        "pct_positive": 7.5403949730700175
      },
      "top_tissue": {
        "count": 2448,
        "max": 2.3173880577087402,
        "mean": 0.06773356348276138,
        "name": "Thyroid gland",
        "pct_positive": 8.57843137254902
      },
      "vector_key": "SIRT6"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "SIRT1",
        "positive_n": 314865,
        "positive_pct": 25.262663826407195,
        "q99_positive": 2.3554694652557373,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "SIRT1",
        "symbol": "SIRT1"
      },
      "celltype_stats": [
        {
          "count": 23737,
          "max": 3.8881139755249023,
          "mean": 0.49732765555381775,
          "name": "Macrophages",
          "pct_positive": 41.146732948561315
        },
        {
          "count": 2201,
          "max": 4.339158058166504,
          "mean": 0.4498737156391144,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 32.07632894139027
        },
        {
          "count": 15287,
          "max": 3.4679112434387207,
          "mean": 0.3886391818523407,
          "name": "B cells",
          "pct_positive": 32.65519722640152
        },
        {
          "count": 14475,
          "max": 3.212752103805542,
          "mean": 0.37232330441474915,
          "name": "Natural killer T cells",
          "pct_positive": 29.879101899827287
        },
        {
          "count": 32911,
          "max": 3.7267754077911377,
          "mean": 0.36964181065559387,
          "name": "Fibroblasts",
          "pct_positive": 38.54030567287533
        },
        {
          "count": 4658,
          "max": 3.6257989406585693,
          "mean": 0.34876811504364014,
          "name": "Smooth muscle cells",
          "pct_positive": 30.828681837698586
        },
        {
          "count": 1909,
          "max": 2.68552303314209,
          "mean": 0.3165091872215271,
          "name": "Monocytes",
          "pct_positive": 26.820324777370352
        },
        {
          "count": 268,
          "max": 2.896928071975708,
          "mean": 0.30464810132980347,
          "name": "Mesothelial cells",
          "pct_positive": 31.716417910447763
        },
        {
          "count": 10260,
          "max": 3.0219480991363525,
          "mean": 0.25024086236953735,
          "name": "Endothelial cells",
          "pct_positive": 23.64522417153996
        },
        {
          "count": 11724,
          "max": 3.4720051288604736,
          "mean": 0.22336335480213165,
          "name": "Adipocytes",
          "pct_positive": 19.617877857386556
        },
        {
          "count": 1671,
          "max": 2.567537784576416,
          "mean": 0.15895822644233704,
          "name": "Dendritic cells",
          "pct_positive": 15.260323159784562
        },
        {
          "count": 554,
          "max": 2.494633197784424,
          "mean": 0.11829762160778046,
          "name": "Follicular cells",
          "pct_positive": 16.425992779783392
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "SIRT1",
      "name": "Sirtuin 1",
      "overall": {
        "max": 4.339158058166504,
        "mean": 0.36871662735939026,
        "median": 0.0,
        "p95": 1.630568265914917,
        "pct_positive": 33.07759809452175
      },
      "pathway": "Sirtuin Family",
      "pmid": "25793536",
      "q99_positive_species": 2.3554694652557373,
      "source_symbol": "SIRT1",
      "symbol": "SIRT1",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 4.339158058166504,
          "mean": 0.37334251403808594,
          "name": "Adipose",
          "pct_positive": 33.4459545931557
        },
        {
          "count": 2448,
          "max": 2.567537784576416,
          "mean": 0.14723578095436096,
          "name": "Thyroid gland",
          "pct_positive": 15.441176470588236
        }
      ],
      "top_celltype": {
        "count": 23737,
        "max": 3.8881139755249023,
        "mean": 0.49732765555381775,
        "name": "Macrophages",
        "pct_positive": 41.146732948561315
      },
      "top_tissue": {
        "count": 117207,
        "max": 4.339158058166504,
        "mean": 0.37334251403808594,
        "name": "Adipose",
        "pct_positive": 33.4459545931557
      },
      "vector_key": "SIRT1"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "SIRT3",
        "positive_n": 125788,
        "positive_pct": 10.09238866624143,
        "q99_positive": 2.101539373397827,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "SIRT3",
        "symbol": "SIRT3"
      },
      "celltype_stats": [
        {
          "count": 11724,
          "max": 3.1380484104156494,
          "mean": 0.1454465091228485,
          "name": "Adipocytes",
          "pct_positive": 13.37427499147049
        },
        {
          "count": 14475,
          "max": 2.703860282897949,
          "mean": 0.11407767981290817,
          "name": "Natural killer T cells",
          "pct_positive": 9.865284974093266
        },
        {
          "count": 15287,
          "max": 2.3985016345977783,
          "mean": 0.083608478307724,
          "name": "B cells",
          "pct_positive": 7.90213907241447
        },
        {
          "count": 554,
          "max": 2.059828758239746,
          "mean": 0.08188889920711517,
          "name": "Follicular cells",
          "pct_positive": 11.371841155234657
        },
        {
          "count": 32911,
          "max": 2.8716795444488525,
          "mean": 0.08017580956220627,
          "name": "Fibroblasts",
          "pct_positive": 10.610434201330863
        },
        {
          "count": 2201,
          "max": 2.422808885574341,
          "mean": 0.07750457525253296,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 6.042707860063608
        },
        {
          "count": 268,
          "max": 1.5568629503250122,
          "mean": 0.0652841106057167,
          "name": "Mesothelial cells",
          "pct_positive": 10.44776119402985
        },
        {
          "count": 10260,
          "max": 3.1185617446899414,
          "mean": 0.06403888016939163,
          "name": "Endothelial cells",
          "pct_positive": 6.68615984405458
        },
        {
          "count": 4658,
          "max": 2.8384995460510254,
          "mean": 0.06250842660665512,
          "name": "Smooth muscle cells",
          "pct_positive": 6.869901245169601
        },
        {
          "count": 23737,
          "max": 2.7471773624420166,
          "mean": 0.058945853263139725,
          "name": "Macrophages",
          "pct_positive": 6.7615958208703715
        },
        {
          "count": 1909,
          "max": 1.5718061923980713,
          "mean": 0.03575568273663521,
          "name": "Monocytes",
          "pct_positive": 3.823991618648507
        },
        {
          "count": 1671,
          "max": 1.9807320833206177,
          "mean": 0.02791854552924633,
          "name": "Dendritic cells",
          "pct_positive": 2.9323758228605628
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "SIRT3",
      "name": "Sirtuin 3",
      "overall": {
        "max": 3.1380484104156494,
        "mean": 0.08331485837697983,
        "median": 0.0,
        "p95": 0.7954492568969727,
        "pct_positive": 8.9030964021562
      },
      "pathway": "Sirtuin Family",
      "pmid": "22234866",
      "q99_positive_species": 2.101539373397827,
      "source_symbol": "SIRT3",
      "symbol": "SIRT3",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 3.1380484104156494,
          "mean": 0.08418288826942444,
          "name": "Adipose",
          "pct_positive": 8.984958236282816
        },
        {
          "count": 2448,
          "max": 2.059828758239746,
          "mean": 0.04175431281328201,
          "name": "Thyroid gland",
          "pct_positive": 4.983660130718954
        }
      ],
      "top_celltype": {
        "count": 11724,
        "max": 3.1380484104156494,
        "mean": 0.1454465091228485,
        "name": "Adipocytes",
        "pct_positive": 13.37427499147049
      },
      "top_tissue": {
        "count": 117207,
        "max": 3.1380484104156494,
        "mean": 0.08418288826942444,
        "name": "Adipose",
        "pct_positive": 8.984958236282816
      },
      "vector_key": "SIRT3"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "IGF1R",
        "positive_n": 574396,
        "positive_pct": 46.08569720747935,
        "q99_positive": 3.4061527252197266,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "IGF1R",
        "symbol": "IGF1R"
      },
      "celltype_stats": [
        {
          "count": 1909,
          "max": 4.445818901062012,
          "mean": 1.606755018234253,
          "name": "Monocytes",
          "pct_positive": 80.88004190675746
        },
        {
          "count": 2201,
          "max": 3.633251667022705,
          "mean": 1.0857263803482056,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 57.79191276692413
        },
        {
          "count": 10260,
          "max": 4.029781341552734,
          "mean": 0.985822319984436,
          "name": "Endothelial cells",
          "pct_positive": 61.44249512670565
        },
        {
          "count": 4658,
          "max": 4.19027042388916,
          "mean": 0.9264330863952637,
          "name": "Smooth muscle cells",
          "pct_positive": 58.75912408759124
        },
        {
          "count": 32911,
          "max": 3.9404425621032715,
          "mean": 0.7979941964149475,
          "name": "Fibroblasts",
          "pct_positive": 62.204126279967184
        },
        {
          "count": 23737,
          "max": 4.118554592132568,
          "mean": 0.6196462512016296,
          "name": "Macrophages",
          "pct_positive": 41.36580022749294
        },
        {
          "count": 268,
          "max": 2.2195780277252197,
          "mean": 0.5241766571998596,
          "name": "Mesothelial cells",
          "pct_positive": 49.62686567164179
        },
        {
          "count": 15287,
          "max": 3.1211230754852295,
          "mean": 0.3665097653865814,
          "name": "B cells",
          "pct_positive": 27.022960685549812
        },
        {
          "count": 14475,
          "max": 3.9088189601898193,
          "mean": 0.3497803211212158,
          "name": "Natural killer T cells",
          "pct_positive": 22.791018998272886
        },
        {
          "count": 554,
          "max": 3.3441805839538574,
          "mean": 0.31437090039253235,
          "name": "Follicular cells",
          "pct_positive": 34.83754512635379
        },
        {
          "count": 11724,
          "max": 2.920969009399414,
          "mean": 0.23398055136203766,
          "name": "Adipocytes",
          "pct_positive": 18.654042988741043
        },
        {
          "count": 1671,
          "max": 2.94880747795105,
          "mean": 0.053036123514175415,
          "name": "Dendritic cells",
          "pct_positive": 4.428485936564932
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "IGF1R",
      "name": "Insulin-like Growth Factor 1 Receptor",
      "overall": {
        "max": 4.445818901062012,
        "mean": 0.6240485906600952,
        "median": 0.0,
        "p95": 2.3190393447875977,
        "pct_positive": 43.59617232877857
      },
      "pathway": "Insulin/IGF-1 Signaling",
      "pmid": "12483226",
      "q99_positive_species": 3.4061527252197266,
      "source_symbol": "IGF1R",
      "symbol": "IGF1R",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 4.445818901062012,
          "mean": 0.6345171928405762,
          "name": "Adipose",
          "pct_positive": 44.25162319656676
        },
        {
          "count": 2448,
          "max": 3.3441805839538574,
          "mean": 0.12282480299472809,
          "name": "Thyroid gland",
          "pct_positive": 12.2140522875817
        }
      ],
      "top_celltype": {
        "count": 1909,
        "max": 4.445818901062012,
        "mean": 1.606755018234253,
        "name": "Monocytes",
        "pct_positive": 80.88004190675746
      },
      "top_tissue": {
        "count": 117207,
        "max": 4.445818901062012,
        "mean": 0.6345171928405762,
        "name": "Adipose",
        "pct_positive": 44.25162319656676
      },
      "vector_key": "IGF1R"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "KL",
        "positive_n": 25561,
        "positive_pct": 2.0508438539272205,
        "q99_positive": 2.4546902179718018,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "KL",
        "symbol": "KLOTHO"
      },
      "celltype_stats": [
        {
          "count": 10260,
          "max": 3.2854185104370117,
          "mean": 0.1405230611562729,
          "name": "Endothelial cells",
          "pct_positive": 12.982456140350877
        },
        {
          "count": 23737,
          "max": 2.9152419567108154,
          "mean": 0.050434842705726624,
          "name": "Macrophages",
          "pct_positive": 4.524581876395501
        },
        {
          "count": 1909,
          "max": 2.2264316082000732,
          "mean": 0.047655876725912094,
          "name": "Monocytes",
          "pct_positive": 3.771608171817706
        },
        {
          "count": 268,
          "max": 1.3514100313186646,
          "mean": 0.022841954603791237,
          "name": "Mesothelial cells",
          "pct_positive": 2.2388059701492535
        },
        {
          "count": 32911,
          "max": 3.3436532020568848,
          "mean": 0.009967057034373283,
          "name": "Fibroblasts",
          "pct_positive": 0.966242289811917
        },
        {
          "count": 2201,
          "max": 2.214475631713867,
          "mean": 0.009466771967709064,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 0.5906406179009541
        },
        {
          "count": 11724,
          "max": 2.0773444175720215,
          "mean": 0.00711541622877121,
          "name": "Adipocytes",
          "pct_positive": 0.6653019447287616
        },
        {
          "count": 4658,
          "max": 2.679495096206665,
          "mean": 0.005771379917860031,
          "name": "Smooth muscle cells",
          "pct_positive": 0.55817947617003
        },
        {
          "count": 14475,
          "max": 2.5775959491729736,
          "mean": 0.0019491477869451046,
          "name": "Natural killer T cells",
          "pct_positive": 0.17271157167530224
        },
        {
          "count": 15287,
          "max": 1.451139211654663,
          "mean": 0.0008282231283374131,
          "name": "B cells",
          "pct_positive": 0.09158108196506835
        },
        {
          "count": 1671,
          "max": 0.0,
          "mean": 0.0,
          "name": "Dendritic cells",
          "pct_positive": 0.0
        },
        {
          "count": 554,
          "max": 0.0,
          "mean": 0.0,
          "name": "Follicular cells",
          "pct_positive": 0.0
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "KL",
      "name": "Klotho Anti-aging Protein",
      "overall": {
        "max": 3.3436532020568848,
        "mean": 0.02704506181180477,
        "median": 0.0,
        "p95": 0.0,
        "pct_positive": 2.472107308511972
      },
      "pathway": "Anti-aging",
      "pmid": "30633899",
      "q99_positive_species": 2.4546902179718018,
      "source_symbol": "KL",
      "symbol": "KLOTHO",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 3.3436532020568848,
          "mean": 0.027540523558855057,
          "name": "Adipose",
          "pct_positive": 2.5186209014819934
        },
        {
          "count": 2448,
          "max": 2.1432712078094482,
          "mean": 0.003322915406897664,
          "name": "Thyroid gland",
          "pct_positive": 0.24509803921568626
        }
      ],
      "top_celltype": {
        "count": 10260,
        "max": 3.2854185104370117,
        "mean": 0.1405230611562729,
        "name": "Endothelial cells",
        "pct_positive": 12.982456140350877
      },
      "top_tissue": {
        "count": 117207,
        "max": 3.3436532020568848,
        "mean": 0.027540523558855057,
        "name": "Adipose",
        "pct_positive": 2.5186209014819934
      },
      "vector_key": "KLOTHO"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "APOC3",
        "positive_n": 22296,
        "positive_pct": 1.7888820690568172,
        "q99_positive": 6.765168190002441,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "APOC3",
        "symbol": "APOC3"
      },
      "celltype_stats": [
        {
          "count": 268,
          "max": 1.4034876823425293,
          "mean": 0.005236894357949495,
          "name": "Mesothelial cells",
          "pct_positive": 0.3731343283582089
        },
        {
          "count": 1909,
          "max": 1.3590983152389526,
          "mean": 0.0007119425572454929,
          "name": "Monocytes",
          "pct_positive": 0.05238344683080147
        },
        {
          "count": 23737,
          "max": 1.792593240737915,
          "mean": 0.00031370160286314785,
          "name": "Macrophages",
          "pct_positive": 0.03791549058431984
        },
        {
          "count": 10260,
          "max": 1.4321657419204712,
          "mean": 0.00013958731142338365,
          "name": "Endothelial cells",
          "pct_positive": 0.009746588693957114
        },
        {
          "count": 14475,
          "max": 0.8817936182022095,
          "mean": 0.00010189483145950362,
          "name": "Natural killer T cells",
          "pct_positive": 0.01381692573402418
        },
        {
          "count": 11724,
          "max": 1.0750465393066406,
          "mean": 9.169622353510931e-05,
          "name": "Adipocytes",
          "pct_positive": 0.0085295121119072
        },
        {
          "count": 32911,
          "max": 1.4239704608917236,
          "mean": 6.43330131424591e-05,
          "name": "Fibroblasts",
          "pct_positive": 0.009115493300112425
        },
        {
          "count": 2201,
          "max": 0.0,
          "mean": 0.0,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 0.0
        },
        {
          "count": 15287,
          "max": 0.0,
          "mean": 0.0,
          "name": "B cells",
          "pct_positive": 0.0
        },
        {
          "count": 1671,
          "max": 0.0,
          "mean": 0.0,
          "name": "Dendritic cells",
          "pct_positive": 0.0
        },
        {
          "count": 554,
          "max": 0.0,
          "mean": 0.0,
          "name": "Follicular cells",
          "pct_positive": 0.0
        },
        {
          "count": 4658,
          "max": 0.0,
          "mean": 0.0,
          "name": "Smooth muscle cells",
          "pct_positive": 0.0
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "APOC3",
      "name": "Apolipoprotein C-III",
      "overall": {
        "max": 1.792593240737915,
        "mean": 0.0001362945477012545,
        "median": 0.0,
        "p95": 0.0,
        "pct_positive": 0.015043249341857842
      },
      "pathway": "Lipid Metabolism",
      "pmid": "16602826",
      "q99_positive_species": 6.765168190002441,
      "source_symbol": "APOC3",
      "symbol": "APOC3",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 1.792593240737915,
          "mean": 0.00013914122246205807,
          "name": "Adipose",
          "pct_positive": 0.015357444521231669
        },
        {
          "count": 2448,
          "max": 0.0,
          "mean": 0.0,
          "name": "Thyroid gland",
          "pct_positive": 0.0
        }
      ],
      "top_celltype": {
        "count": 268,
        "max": 1.4034876823425293,
        "mean": 0.005236894357949495,
        "name": "Mesothelial cells",
        "pct_positive": 0.3731343283582089
      },
      "top_tissue": {
        "count": 117207,
        "max": 1.792593240737915,
        "mean": 0.00013914122246205807,
        "name": "Adipose",
        "pct_positive": 0.015357444521231669
      },
      "vector_key": "APOC3"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "IL6",
        "positive_n": 69252,
        "positive_pct": 5.556317772081212,
        "q99_positive": 4.358819484710693,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "IL6",
        "symbol": "IL6"
      },
      "celltype_stats": [
        {
          "count": 268,
          "max": 3.187959909439087,
          "mean": 0.673810601234436,
          "name": "Mesothelial cells",
          "pct_positive": 56.343283582089555
        },
        {
          "count": 10260,
          "max": 5.31935453414917,
          "mean": 0.29297512769699097,
          "name": "Endothelial cells",
          "pct_positive": 18.596491228070175
        },
        {
          "count": 32911,
          "max": 4.063427925109863,
          "mean": 0.18362262845039368,
          "name": "Fibroblasts",
          "pct_positive": 15.186411837987299
        },
        {
          "count": 4658,
          "max": 3.529867172241211,
          "mean": 0.1612895280122757,
          "name": "Smooth muscle cells",
          "pct_positive": 11.442679261485617
        },
        {
          "count": 2201,
          "max": 3.4413485527038574,
          "mean": 0.1149248257279396,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 8.450704225352112
        },
        {
          "count": 1909,
          "max": 2.616370916366577,
          "mean": 0.06204375624656677,
          "name": "Monocytes",
          "pct_positive": 5.133577789418544
        },
        {
          "count": 23737,
          "max": 3.105414390563965,
          "mean": 0.05355362594127655,
          "name": "Macrophages",
          "pct_positive": 5.421915153557737
        },
        {
          "count": 15287,
          "max": 3.259669542312622,
          "mean": 0.03764144331216812,
          "name": "B cells",
          "pct_positive": 3.061424739975142
        },
        {
          "count": 1671,
          "max": 3.7390995025634766,
          "mean": 0.019855216145515442,
          "name": "Dendritic cells",
          "pct_positive": 1.2567324955116697
        },
        {
          "count": 14475,
          "max": 2.6237785816192627,
          "mean": 0.011950255371630192,
          "name": "Natural killer T cells",
          "pct_positive": 1.2089810017271159
        },
        {
          "count": 554,
          "max": 1.1062028408050537,
          "mean": 0.00822523608803749,
          "name": "Follicular cells",
          "pct_positive": 1.263537906137184
        },
        {
          "count": 11724,
          "max": 2.12911319732666,
          "mean": 0.00411640852689743,
          "name": "Adipocytes",
          "pct_positive": 0.3838280450358239
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "IL6",
      "name": "Interleukin 6",
      "overall": {
        "max": 5.31935453414917,
        "mean": 0.10411593317985535,
        "median": 0.0,
        "p95": 0.9194221496582031,
        "pct_positive": 8.254565208307216
      },
      "pathway": "Inflammation",
      "pmid": "22234866",
      "q99_positive_species": 4.358819484710693,
      "source_symbol": "IL6",
      "symbol": "IL6",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 4.100638389587402,
          "mean": 0.10544010251760483,
          "name": "Adipose",
          "pct_positive": 8.379192369056456
        },
        {
          "count": 2448,
          "max": 5.31935453414917,
          "mean": 0.04071580991148949,
          "name": "Thyroid gland",
          "pct_positive": 2.287581699346405
        }
      ],
      "top_celltype": {
        "count": 268,
        "max": 3.187959909439087,
        "mean": 0.673810601234436,
        "name": "Mesothelial cells",
        "pct_positive": 56.343283582089555
      },
      "top_tissue": {
        "count": 117207,
        "max": 4.100638389587402,
        "mean": 0.10544010251760483,
        "name": "Adipose",
        "pct_positive": 8.379192369056456
      },
      "vector_key": "IL6"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "TERT",
        "positive_n": 2751,
        "positive_pct": 0.22072185916645606,
        "q99_positive": 1.945739507675171,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "TERT",
        "symbol": "TERT"
      },
      "celltype_stats": [
        {
          "count": 268,
          "max": 1.4655683040618896,
          "mean": 0.007311257068067789,
          "name": "Mesothelial cells",
          "pct_positive": 0.7462686567164178
        },
        {
          "count": 4658,
          "max": 2.0971410274505615,
          "mean": 0.0009995147120207548,
          "name": "Smooth muscle cells",
          "pct_positive": 0.064405324173465
        },
        {
          "count": 11724,
          "max": 1.1723750829696655,
          "mean": 0.0009411365608684719,
          "name": "Adipocytes",
          "pct_positive": 0.1023541453428864
        },
        {
          "count": 15287,
          "max": 1.4766783714294434,
          "mean": 0.0008785433019511402,
          "name": "B cells",
          "pct_positive": 0.11774710538365932
        },
        {
          "count": 2201,
          "max": 1.8280805349349976,
          "mean": 0.0008305681403726339,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 0.045433893684688774
        },
        {
          "count": 1909,
          "max": 1.114322304725647,
          "mean": 0.0005837204516865313,
          "name": "Monocytes",
          "pct_positive": 0.05238344683080147
        },
        {
          "count": 23737,
          "max": 1.8241468667984009,
          "mean": 0.00042708314140327275,
          "name": "Macrophages",
          "pct_positive": 0.050553987445759785
        },
        {
          "count": 14475,
          "max": 1.3501384258270264,
          "mean": 0.0003331777115818113,
          "name": "Natural killer T cells",
          "pct_positive": 0.03454231433506045
        },
        {
          "count": 32911,
          "max": 1.5466028451919556,
          "mean": 0.000316179939545691,
          "name": "Fibroblasts",
          "pct_positive": 0.04557746650056212
        },
        {
          "count": 10260,
          "max": 0.5370690822601318,
          "mean": 0.00013018498430028558,
          "name": "Endothelial cells",
          "pct_positive": 0.029239766081871347
        },
        {
          "count": 1671,
          "max": 0.0,
          "mean": 0.0,
          "name": "Dendritic cells",
          "pct_positive": 0.0
        },
        {
          "count": 554,
          "max": 0.0,
          "mean": 0.0,
          "name": "Follicular cells",
          "pct_positive": 0.0
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "TERT",
      "name": "Telomerase Reverse Transcriptase",
      "overall": {
        "max": 2.0971410274505615,
        "mean": 0.0005074894870631397,
        "median": 0.0,
        "p95": 0.0,
        "pct_positive": 0.06017299736743137
      },
      "pathway": "Telomere Maintenance",
      "pmid": "39132489",
      "q99_positive_species": 1.945739507675171,
      "source_symbol": "TERT",
      "symbol": "TERT",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 2.0971410274505615,
          "mean": 0.0005180889274924994,
          "name": "Adipose",
          "pct_positive": 0.061429778084926674
        },
        {
          "count": 2448,
          "max": 0.0,
          "mean": 0.0,
          "name": "Thyroid gland",
          "pct_positive": 0.0
        }
      ],
      "top_celltype": {
        "count": 268,
        "max": 1.4655683040618896,
        "mean": 0.007311257068067789,
        "name": "Mesothelial cells",
        "pct_positive": 0.7462686567164178
      },
      "top_tissue": {
        "count": 117207,
        "max": 2.0971410274505615,
        "mean": 0.0005180889274924994,
        "name": "Adipose",
        "pct_positive": 0.061429778084926674
      },
      "vector_key": "TERT"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "IRS2",
        "positive_n": 426152,
        "positive_pct": 34.19158914122268,
        "q99_positive": 3.3082995414733887,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "IRS2",
        "symbol": "IRS2"
      },
      "celltype_stats": [
        {
          "count": 1909,
          "max": 4.131627559661865,
          "mean": 1.4258711338043213,
          "name": "Monocytes",
          "pct_positive": 76.79413305395495
        },
        {
          "count": 23737,
          "max": 4.614387512207031,
          "mean": 1.046120285987854,
          "name": "Macrophages",
          "pct_positive": 60.845936723259044
        },
        {
          "count": 11724,
          "max": 3.5780255794525146,
          "mean": 0.7888962626457214,
          "name": "Adipocytes",
          "pct_positive": 53.7956328897987
        },
        {
          "count": 268,
          "max": 2.036881923675537,
          "mean": 0.4275527596473694,
          "name": "Mesothelial cells",
          "pct_positive": 51.11940298507462
        },
        {
          "count": 14475,
          "max": 3.288642644882202,
          "mean": 0.4162577986717224,
          "name": "Natural killer T cells",
          "pct_positive": 30.65284974093264
        },
        {
          "count": 32911,
          "max": 3.632270097732544,
          "mean": 0.4042418599128723,
          "name": "Fibroblasts",
          "pct_positive": 41.64261189268026
        },
        {
          "count": 4658,
          "max": 3.125127077102661,
          "mean": 0.3938297629356384,
          "name": "Smooth muscle cells",
          "pct_positive": 34.90768570201803
        },
        {
          "count": 2201,
          "max": 3.2871756553649902,
          "mean": 0.33257803320884705,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 24.852339845524764
        },
        {
          "count": 1671,
          "max": 3.2284202575683594,
          "mean": 0.30963626503944397,
          "name": "Dendritic cells",
          "pct_positive": 27.109515260323157
        },
        {
          "count": 15287,
          "max": 3.579718828201294,
          "mean": 0.2872811555862427,
          "name": "B cells",
          "pct_positive": 23.340092889383136
        },
        {
          "count": 554,
          "max": 2.411644458770752,
          "mean": 0.22051195800304413,
          "name": "Follicular cells",
          "pct_positive": 27.256317689530686
        },
        {
          "count": 10260,
          "max": 3.2317328453063965,
          "mean": 0.13106435537338257,
          "name": "Endothelial cells",
          "pct_positive": 11.481481481481481
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "IRS2",
      "name": "Insulin Receptor Substrate 2",
      "overall": {
        "max": 4.614387512207031,
        "mean": 0.5448088049888611,
        "median": 0.0,
        "p95": 2.1208841800689697,
        "pct_positive": 40.13037482762943
      },
      "pathway": "Insulin/IGF-1 Signaling",
      "pmid": "19887537",
      "q99_positive_species": 3.3082995414733887,
      "source_symbol": "IRS2",
      "symbol": "IRS2",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 4.614387512207031,
          "mean": 0.549677848815918,
          "name": "Adipose",
          "pct_positive": 40.38410675130325
        },
        {
          "count": 2448,
          "max": 3.2284202575683594,
          "mean": 0.3116878569126129,
          "name": "Thyroid gland",
          "pct_positive": 27.98202614379085
        }
      ],
      "top_celltype": {
        "count": 1909,
        "max": 4.131627559661865,
        "mean": 1.4258711338043213,
        "name": "Monocytes",
        "pct_positive": 76.79413305395495
      },
      "top_tissue": {
        "count": 117207,
        "max": 4.614387512207031,
        "mean": 0.549677848815918,
        "name": "Adipose",
        "pct_positive": 40.38410675130325
      },
      "vector_key": "IRS2"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "TP53",
        "positive_n": 170394,
        "positive_pct": 13.671276070813926,
        "q99_positive": 2.170886993408203,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "TP53",
        "symbol": "TP53"
      },
      "celltype_stats": [
        {
          "count": 268,
          "max": 1.919667363166809,
          "mean": 0.25507667660713196,
          "name": "Mesothelial cells",
          "pct_positive": 31.716417910447763
        },
        {
          "count": 15287,
          "max": 2.7673542499542236,
          "mean": 0.2515851855278015,
          "name": "B cells",
          "pct_positive": 21.59351082619219
        },
        {
          "count": 14475,
          "max": 3.457505464553833,
          "mean": 0.17326299846172333,
          "name": "Natural killer T cells",
          "pct_positive": 14.238341968911916
        },
        {
          "count": 10260,
          "max": 2.7322754859924316,
          "mean": 0.15670302510261536,
          "name": "Endothelial cells",
          "pct_positive": 16.023391812865498
        },
        {
          "count": 23737,
          "max": 2.8301384449005127,
          "mean": 0.12159930914640427,
          "name": "Macrophages",
          "pct_positive": 14.715423179003245
        },
        {
          "count": 1671,
          "max": 2.5210494995117188,
          "mean": 0.1095748171210289,
          "name": "Dendritic cells",
          "pct_positive": 11.968880909634949
        },
        {
          "count": 4658,
          "max": 2.5957729816436768,
          "mean": 0.1041446328163147,
          "name": "Smooth muscle cells",
          "pct_positive": 11.421210820094462
        },
        {
          "count": 32911,
          "max": 3.355590343475342,
          "mean": 0.10294405370950699,
          "name": "Fibroblasts",
          "pct_positive": 14.490595849412049
        },
        {
          "count": 554,
          "max": 2.7721199989318848,
          "mean": 0.09638191014528275,
          "name": "Follicular cells",
          "pct_positive": 11.913357400722022
        },
        {
          "count": 1909,
          "max": 2.968106508255005,
          "mean": 0.08089252561330795,
          "name": "Monocytes",
          "pct_positive": 7.85751702462022
        },
        {
          "count": 2201,
          "max": 2.469510316848755,
          "mean": 0.07312352955341339,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 7.269422989550205
        },
        {
          "count": 11724,
          "max": 2.458199977874756,
          "mean": 0.06511816382408142,
          "name": "Adipocytes",
          "pct_positive": 6.013306038894576
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "TP53",
      "name": "Tumor Protein P53",
      "overall": {
        "max": 3.457505464553833,
        "mean": 0.13459451496601105,
        "median": 0.0,
        "p95": 1.0657273530960083,
        "pct_positive": 14.346245455685095
      },
      "pathway": "Tumor Suppression",
      "pmid": "17667954",
      "q99_positive_species": 2.170886993408203,
      "source_symbol": "TP53",
      "symbol": "TP53",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 3.457505464553833,
          "mean": 0.13509421050548553,
          "name": "Adipose",
          "pct_positive": 14.3873659423072
        },
        {
          "count": 2448,
          "max": 2.7721199989318848,
          "mean": 0.11067047715187073,
          "name": "Thyroid gland",
          "pct_positive": 12.377450980392158
        }
      ],
      "top_celltype": {
        "count": 268,
        "max": 1.919667363166809,
        "mean": 0.25507667660713196,
        "name": "Mesothelial cells",
        "pct_positive": 31.716417910447763
      },
      "top_tissue": {
        "count": 117207,
        "max": 3.457505464553833,
        "mean": 0.13509421050548553,
        "name": "Adipose",
        "pct_positive": 14.3873659423072
      },
      "vector_key": "TP53"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "SHC1",
        "positive_n": 172211,
        "positive_pct": 13.817060010510565,
        "q99_positive": 2.1945977210998535,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "SHC1",
        "symbol": "SHC1"
      },
      "celltype_stats": [
        {
          "count": 10260,
          "max": 3.1731791496276855,
          "mean": 0.33595362305641174,
          "name": "Endothelial cells",
          "pct_positive": 30.838206627680314
        },
        {
          "count": 268,
          "max": 1.464672565460205,
          "mean": 0.25056132674217224,
          "name": "Mesothelial cells",
          "pct_positive": 36.19402985074627
        },
        {
          "count": 11724,
          "max": 2.7235872745513916,
          "mean": 0.22770686447620392,
          "name": "Adipocytes",
          "pct_positive": 20.46229955646537
        },
        {
          "count": 4658,
          "max": 2.773526668548584,
          "mean": 0.19091209769248962,
          "name": "Smooth muscle cells",
          "pct_positive": 20.502361528553024
        },
        {
          "count": 32911,
          "max": 3.0154683589935303,
          "mean": 0.1771516054868698,
          "name": "Fibroblasts",
          "pct_positive": 24.22594269393212
        },
        {
          "count": 554,
          "max": 2.039785861968994,
          "mean": 0.1455078274011612,
          "name": "Follicular cells",
          "pct_positive": 20.03610108303249
        },
        {
          "count": 2201,
          "max": 2.5904316902160645,
          "mean": 0.12121282517910004,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 10.949568378009996
        },
        {
          "count": 23737,
          "max": 3.275078058242798,
          "mean": 0.10825216770172119,
          "name": "Macrophages",
          "pct_positive": 13.620086784345114
        },
        {
          "count": 1909,
          "max": 1.9125514030456543,
          "mean": 0.0850750282406807,
          "name": "Monocytes",
          "pct_positive": 8.64326872708224
        },
        {
          "count": 1671,
          "max": 2.6792843341827393,
          "mean": 0.08115040510892868,
          "name": "Dendritic cells",
          "pct_positive": 8.677438659485338
        },
        {
          "count": 14475,
          "max": 2.64905047416687,
          "mean": 0.06270861625671387,
          "name": "Natural killer T cells",
          "pct_positive": 5.796200345423143
        },
        {
          "count": 15287,
          "max": 1.9327409267425537,
          "mean": 0.061031654477119446,
          "name": "B cells",
          "pct_positive": 6.240596585333944
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "SHC1",
      "name": "SHC Adaptor Protein 1",
      "overall": {
        "max": 3.275078058242798,
        "mean": 0.15008872747421265,
        "median": 0.0,
        "p95": 1.0579681396484375,
        "pct_positive": 16.94538464752831
      },
      "pathway": "Signal Transduction",
      "pmid": "14530863",
      "q99_positive_species": 2.1945977210998535,
      "source_symbol": "SHC1",
      "symbol": "SHC1",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 3.275078058242798,
          "mean": 0.15057767927646637,
          "name": "Adipose",
          "pct_positive": 17.01860810361156
        },
        {
          "count": 2448,
          "max": 3.1731791496276855,
          "mean": 0.12667794525623322,
          "name": "Thyroid gland",
          "pct_positive": 13.43954248366013
        }
      ],
      "top_celltype": {
        "count": 10260,
        "max": 3.1731791496276855,
        "mean": 0.33595362305641174,
        "name": "Endothelial cells",
        "pct_positive": 30.838206627680314
      },
      "top_tissue": {
        "count": 117207,
        "max": 3.275078058242798,
        "mean": 0.15057767927646637,
        "name": "Adipose",
        "pct_positive": 17.01860810361156
      },
      "vector_key": "SHC1"
    },
    {
      "calibration": {
        "fallback_reason": null,
        "fallback_used": false,
        "matrix_symbol": "ACE",
        "positive_n": 40647,
        "positive_pct": 3.261243696669916,
        "q99_positive": 2.4906063079833984,
        "quantile_method": "linear",
        "reference_n_cells": 1246365,
        "source_symbol": "ACE",
        "symbol": "ACE"
      },
      "celltype_stats": [
        {
          "count": 10260,
          "max": 3.3622887134552,
          "mean": 0.12985435128211975,
          "name": "Endothelial cells",
          "pct_positive": 10.23391812865497
        },
        {
          "count": 32911,
          "max": 3.1750082969665527,
          "mean": 0.08755763620138168,
          "name": "Fibroblasts",
          "pct_positive": 9.227917717480477
        },
        {
          "count": 268,
          "max": 1.3098527193069458,
          "mean": 0.039295174181461334,
          "name": "Mesothelial cells",
          "pct_positive": 5.223880597014925
        },
        {
          "count": 23737,
          "max": 2.638129234313965,
          "mean": 0.034230224788188934,
          "name": "Macrophages",
          "pct_positive": 3.446096810885959
        },
        {
          "count": 2201,
          "max": 2.943681478500366,
          "mean": 0.02965313382446766,
          "name": "Adipocyte progenitor cells",
          "pct_positive": 2.407996365288505
        },
        {
          "count": 11724,
          "max": 2.4804725646972656,
          "mean": 0.023302705958485603,
          "name": "Adipocytes",
          "pct_positive": 2.106789491641078
        },
        {
          "count": 4658,
          "max": 2.510591983795166,
          "mean": 0.013730120845139027,
          "name": "Smooth muscle cells",
          "pct_positive": 1.051953628166595
        },
        {
          "count": 1909,
          "max": 1.2022954225540161,
          "mean": 0.011296357959508896,
          "name": "Monocytes",
          "pct_positive": 1.5191199580932426
        },
        {
          "count": 1671,
          "max": 2.256993293762207,
          "mean": 0.01036752387881279,
          "name": "Dendritic cells",
          "pct_positive": 1.0173548773189707
        },
        {
          "count": 14475,
          "max": 2.6502723693847656,
          "mean": 0.009024255909025669,
          "name": "Natural killer T cells",
          "pct_positive": 0.7599309153713298
        },
        {
          "count": 15287,
          "max": 2.2358274459838867,
          "mean": 0.0029707541689276695,
          "name": "B cells",
          "pct_positive": 0.30745077516844377
        },
        {
          "count": 554,
          "max": 0.0,
          "mean": 0.0,
          "name": "Follicular cells",
          "pct_positive": 0.0
        }
      ],
      "mapping_method": "case_insensitive_exact",
      "matrix_symbol": "ACE",
      "name": "Angiotensin-Converting Enzyme",
      "overall": {
        "max": 3.3622887134552,
        "mean": 0.047255195677280426,
        "median": 0.0,
        "p95": 0.0,
        "pct_positive": 4.572312063850236
      },
      "pathway": "Signal Transduction",
      "pmid": "16463022",
      "q99_positive_species": 2.4906063079833984,
      "source_symbol": "ACE",
      "symbol": "ACE",
      "tissue_stats": [
        {
          "count": 117207,
          "max": 3.3622887134552,
          "mean": 0.0477655827999115,
          "name": "Adipose",
          "pct_positive": 4.63368228860051
        },
        {
          "count": 2448,
          "max": 3.11626935005188,
          "mean": 0.02281865105032921,
          "name": "Thyroid gland",
          "pct_positive": 1.6339869281045754
        }
      ],
      "top_celltype": {
        "count": 10260,
        "max": 3.3622887134552,
        "mean": 0.12985435128211975,
        "name": "Endothelial cells",
        "pct_positive": 10.23391812865497
      },
      "top_tissue": {
        "count": 117207,
        "max": 3.3622887134552,
        "mean": 0.0477655827999115,
        "name": "Adipose",
        "pct_positive": 4.63368228860051
      },
      "vector_key": "ACE"
    }
  ],
  "interpretation": "Descriptive relative-expression scores only. Compare scores only within the same source species and an identical mapped gene set. Higher expression scores do not imply a pro-longevity direction, and these results do not establish causality.",
  "method_status": "validated_real",
  "schema_version": "2.0",
  "signature": {
    "coverage_status": "full",
    "denominator_gene_count": 15,
    "gene_set_id": "LACA-LONGEVITY-15-v1",
    "mapped_count": 15,
    "mapped_genes": [
      "APOE",
      "FOXO3",
      "CETP",
      "SIRT6",
      "SIRT1",
      "SIRT3",
      "IGF1R",
      "KLOTHO",
      "APOC3",
      "IL6",
      "TERT",
      "IRS2",
      "TP53",
      "SHC1",
      "ACE"
    ],
    "mapping_method": "case_insensitive_exact",
    "missing_gene_handling": "none_missing",
    "missing_genes": [],
    "ortholog_inference": false,
    "score_basis": "all_curated_genes",
    "total_genes": 15
  },
  "status": "available"
}
