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chondrocytes", "pct_positive": 0.0 }, { "count": 70, "max": 0.0, "mean": 0.0, "name": "Inflammatory chondrocytes", "pct_positive": 0.0 }, { "count": 37, "max": 0.0, "mean": 0.0, "name": "Mast cells", "pct_positive": 0.0 }, { "count": 3, "max": 0.0, "mean": 0.0, "name": "Monocytes", "pct_positive": 0.0 }, { "count": 8, "max": 0.0, "mean": 0.0, "name": "Natural killer T cells", "pct_positive": 0.0 }, { "count": 1, "max": 0.0, "mean": 0.0, "name": "Plasma B cells", "pct_positive": 0.0 }, { "count": 1476, "max": 0.0, "mean": 0.0, "name": "Pre-hypertrophic chondrocytes", "pct_positive": 0.0 }, { "count": 26, "max": 0.0, "mean": 0.0, "name": "Pre-inflammatory chondrocytes", "pct_positive": 0.0 }, { "count": 2584, "max": 0.0, "mean": 0.0, "name": "Precursor fibrocartilage chondrocytes", "pct_positive": 0.0 }, { "count": 49, "max": 0.0, "mean": 0.0, "name": "Progenitor-like epithelial cells", "pct_positive": 0.0 }, { "count": 963, "max": 0.0, "mean": 0.0, "name": "Proliferative chondrocytes", "pct_positive": 0.0 }, { "count": 1992, "max": 0.0, "mean": 0.0, "name": "Regulatory chondrocytes", "pct_positive": 0.0 }, { "count": 914, "max": 0.0, "mean": 0.0, "name": "Reparative chondrocytes", "pct_positive": 0.0 }, { "count": 126, "max": 0.0, "mean": 0.0, "name": "Type I myonuclei", "pct_positive": 0.0 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "ACE", "name": "Angiotensin-Converting Enzyme", "overall": { "max": 3.431088447570801, "mean": 0.0343647338449955, "median": 0.0, "p95": 0.0, "pct_positive": 3.8240886969413737 }, "pathway": "Signal Transduction", "pmid": "16463022", "q99_positive_species": 2.4906063079833984, "source_symbol": "ACE", "symbol": "ACE", "tissue_stats": [ { "count": 5718, "max": 3.431088447570801, "mean": 0.08915459364652634, "name": "Muscle", "pct_positive": 4.022385449457853 }, { "count": 39846, "max": 2.5030040740966797, "mean": 0.04072387143969536, "name": "Skeletal muscle", "pct_positive": 5.378206093459821 }, { "count": 16490, "max": 0.0, "mean": 0.0, "name": "Cartilage", "pct_positive": 0.0 } ], "top_celltype": { "count": 7609, "max": 3.431088447570801, "mean": 0.13553273677825928, "name": "Endothelial cells", "pct_positive": 10.724142462872914 }, "top_tissue": { "count": 5718, "max": 3.431088447570801, "mean": 0.08915459364652634, "name": "Muscle", "pct_positive": 4.022385449457853 }, "vector_key": "ACE" } ], "interpretation": "Descriptive relative-expression scores only. Compare scores only within the same source species and an identical mapped gene set. Higher expression scores do not imply a pro-longevity direction, and these results do not establish causality.", "method_status": "validated_real", "schema_version": "2.0", "signature": { "coverage_status": "full", "denominator_gene_count": 15, "gene_set_id": "LACA-LONGEVITY-15-v1", "mapped_count": 15, "mapped_genes": [ "APOE", "FOXO3", "CETP", "SIRT6", "SIRT1", "SIRT3", "IGF1R", "KLOTHO", "APOC3", "IL6", "TERT", "IRS2", "TP53", "SHC1", "ACE" ], "mapping_method": "case_insensitive_exact", "missing_gene_handling": "none_missing", "missing_genes": [], "ortholog_inference": false, "score_basis": "all_curated_genes", "total_genes": 15 }, "status": "available" }