{ "dataset": { "celltype_key": "laca_curated_celltype_v3", "expression": "Values are read directly from the source H5AD X matrix; the exporter applies no expression transformation.", "generated_at": "2026-08-07T17:18:42.138118+00:00", "item_id": "sys09", "mode": "system", "n_cells": 45640, "n_genes_in_matrix": 19739, "page_key": "system:SP121:sys09", "source_file": "SP121.h5ad", "sp_id": "SP121", "tissue_key": "Tissue" }, "downloads": { "summary_csv": "summary.csv" }, "gene_set": { "celltype_stats": [ { "count": 7317, "max": 0.2549596428871155, "mean": 0.08514079451560974, "name": "Macrophages", "pct_positive": 94.32827661609949 }, { "count": 1192, "max": 0.233744814991951, "mean": 0.07102532684803009, "name": "Monocytes", "pct_positive": 87.33221476510067 }, { "count": 13016, "max": 0.2594641149044037, "mean": 0.06573987007141113, "name": "Urothelial cells", "pct_positive": 97.95636140135218 }, { "count": 2396, "max": 0.2650700807571411, "mean": 0.05964692309498787, "name": "Smooth muscle cells", "pct_positive": 80.13355592654425 }, { "count": 696, "max": 0.1736404448747635, "mean": 0.05634584650397301, "name": "Intercalated cells", "pct_positive": 90.08620689655173 }, { "count": 2342, "max": 0.21405595541000366, "mean": 0.05214144289493561, "name": "Endothelial cells", "pct_positive": 71.77625960717336 }, { "count": 5808, "max": 0.20693762600421906, "mean": 0.05080176144838333, "name": "Proximal tubule cells", "pct_positive": 85.65771349862258 }, { "count": 761, "max": 0.15342311561107635, "mean": 0.042205069214105606, "name": "Ascending loop of Henle cells", "pct_positive": 80.946123521682 }, { "count": 8840, "max": 0.21242277324199677, "mean": 0.04116110876202583, "name": "T cells", "pct_positive": 72.87330316742081 }, { "count": 1484, "max": 0.19215989112854004, "mean": 0.03797043114900589, "name": "Principal cells", "pct_positive": 73.24797843665768 }, { "count": 63, "max": 0.14382712543010712, "mean": 0.03603377193212509, "name": "Podocytes", "pct_positive": 73.01587301587301 }, { "count": 489, "max": 0.21814502775669098, "mean": 0.03593602403998375, "name": "Fibroblasts", "pct_positive": 67.89366053169734 }, { "count": 1087, "max": 0.23713533580303192, "mean": 0.023767856881022453, "name": "Natural killer T cells", "pct_positive": 37.90248390064397 }, { "count": 149, "max": 0.1706530898809433, "mean": 0.016710681840777397, "name": "Connecting tubule cells", "pct_positive": 30.87248322147651 } ], "coverage_status": "full", "denominator_gene_count": 15, "mapped_count": 15, "method": { "alias": { "KLOTHO": "KL" }, "calibration": [ { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "APOE", "positive_n": 245743, "positive_pct": 19.716776385729702, "q99_positive": 4.913139343261719, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "APOE", "symbol": "APOE" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "FOXO3", "positive_n": 727901, "positive_pct": 58.401912762312804, "q99_positive": 3.682433843612671, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "FOXO3", "symbol": "FOXO3" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "CETP", "positive_n": 15958, "positive_pct": 1.2803632964661236, "q99_positive": 2.8351151943206787, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "CETP", "symbol": "CETP" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "SIRT6", "positive_n": 94936, "positive_pct": 7.617030324182723, "q99_positive": 2.0462136268615723, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "SIRT6", "symbol": "SIRT6" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "SIRT1", "positive_n": 314865, "positive_pct": 25.262663826407195, "q99_positive": 2.3554694652557373, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "SIRT1", "symbol": "SIRT1" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "SIRT3", "positive_n": 125788, "positive_pct": 10.09238866624143, "q99_positive": 2.101539373397827, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "SIRT3", "symbol": "SIRT3" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "IGF1R", "positive_n": 574396, "positive_pct": 46.08569720747935, "q99_positive": 3.4061527252197266, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "IGF1R", "symbol": "IGF1R" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "KL", "positive_n": 25561, "positive_pct": 2.0508438539272205, "q99_positive": 2.4546902179718018, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "KL", "symbol": "KLOTHO" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "APOC3", "positive_n": 22296, "positive_pct": 1.7888820690568172, "q99_positive": 6.765168190002441, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "APOC3", "symbol": "APOC3" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "IL6", "positive_n": 69252, "positive_pct": 5.556317772081212, "q99_positive": 4.358819484710693, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "IL6", "symbol": "IL6" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "TERT", "positive_n": 2751, "positive_pct": 0.22072185916645606, "q99_positive": 1.945739507675171, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "TERT", "symbol": "TERT" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "IRS2", "positive_n": 426152, "positive_pct": 34.19158914122268, "q99_positive": 3.3082995414733887, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "IRS2", "symbol": "IRS2" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "TP53", "positive_n": 170394, "positive_pct": 13.671276070813926, "q99_positive": 2.170886993408203, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "TP53", "symbol": "TP53" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "SHC1", "positive_n": 172211, "positive_pct": 13.817060010510565, "q99_positive": 2.1945977210998535, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "SHC1", "symbol": "SHC1" }, { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "ACE", "positive_n": 40647, "positive_pct": 3.261243696669916, "q99_positive": 2.4906063079833984, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "ACE", "symbol": "ACE" } ], "causal_interpretation": false, "comparison_scope": "same_source_species_and_identical_mapped_gene_set_only", "coverage_status": "full", "curated_genes": [ "APOE", "FOXO3", "CETP", "SIRT6", "SIRT1", "SIRT3", "IGF1R", "KLOTHO", "APOC3", "IL6", "TERT", "IRS2", "TP53", "SHC1", "ACE" ], "denominator_gene_count": 15, "directionality": "relative_expression_not_pro_longevity_direction", "formula": "mean(clip(matrix_value / species_positive_q99, 0, 1))", "gene_set_id": "LACA-LONGEVITY-15-v1", "genes": [ "APOE", "FOXO3", "CETP", "SIRT6", "SIRT1", "SIRT3", "IGF1R", "KLOTHO", "APOC3", "IL6", "TERT", "IRS2", "TP53", "SHC1", "ACE" ], "missing_gene_handling": "not_applicable_all_curated_genes_mapped", "name": "Equal-weight species-calibrated relative expression score", "normalization": "Each mapped gene is scaled by its 99th percentile among positive cells in the complete source-species H5AD.", "range": [ 0, 1 ], "score_basis": "all_curated_genes" }, "missing_gene_handling": "none_missing", "missing_genes": [], "name": "Longevity Gene Set", "overall": { "max": 0.2650700807571411, "mean": 0.058350324630737305, "mean_genes_detected": 2.4406660823838737, "median": 0.05614076554775238, "median_genes_detected": 2.0, "p95": 0.13055066764354706, "pct_any_gene": 85.18185801928134, "pct_positive": 85.18185801928134 }, "pathway": "Curated 15-gene signature", "score_basis": "all_curated_genes", "symbol": "LONGEVITY_SET", "tissue_stats": [ { "count": 33367, "max": 0.2650700807571411, "mean": 0.06291503459215164, "name": "Bladder", "pct_positive": 87.8083136032607 }, { "count": 12273, "max": 0.21814502775669098, "mean": 0.04594011604785919, "name": "Kidney", "pct_positive": 78.041228713436 } ], "top_celltype": { "count": 7317, "max": 0.2549596428871155, "mean": 0.08514079451560974, "name": "Macrophages", "pct_positive": 94.32827661609949 }, "top_tissue": { "count": 33367, "max": 0.2650700807571411, "mean": 0.06291503459215164, "name": "Bladder", "pct_positive": 87.8083136032607 }, "total_genes": 15, "vector_key": "LONGEVITY_SET" }, "genes": [ { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "APOE", "positive_n": 245743, "positive_pct": 19.716776385729702, "q99_positive": 4.913139343261719, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "APOE", "symbol": "APOE" }, "celltype_stats": [ { "count": 696, "max": 5.016286849975586, "mean": 1.705432415008545, "name": "Intercalated cells", "pct_positive": 74.85632183908046 }, { "count": 5808, "max": 5.523276329040527, "mean": 1.3304771184921265, "name": "Proximal tubule cells", "pct_positive": 61.36363636363637 }, { "count": 7317, "max": 5.566500186920166, "mean": 0.8429723381996155, "name": "Macrophages", "pct_positive": 38.28071614049474 }, { "count": 63, "max": 3.2942492961883545, "mean": 0.48937976360321045, "name": "Podocytes", "pct_positive": 26.984126984126984 }, { "count": 2396, "max": 5.592812538146973, "mean": 0.1968684196472168, "name": "Smooth muscle cells", "pct_positive": 11.018363939899833 }, { "count": 489, "max": 2.5463225841522217, "mean": 0.18077769875526428, "name": "Fibroblasts", "pct_positive": 14.314928425357873 }, { "count": 761, "max": 3.210287094116211, "mean": 0.1613117754459381, "name": "Ascending loop of Henle cells", "pct_positive": 13.534822601839686 }, { "count": 2342, "max": 4.424190044403076, "mean": 0.10714395344257355, "name": "Endothelial cells", "pct_positive": 6.789069171648164 }, { "count": 1484, "max": 2.8998982906341553, "mean": 0.10039073973894119, "name": "Principal cells", "pct_positive": 8.692722371967655 }, { "count": 8840, "max": 5.0978193283081055, "mean": 0.06354381144046783, "name": "T cells", "pct_positive": 5.04524886877828 }, { "count": 1192, "max": 3.6867125034332275, "mean": 0.06341654807329178, "name": "Monocytes", "pct_positive": 5.704697986577181 }, { "count": 13016, "max": 3.3740031719207764, "mean": 0.05567130446434021, "name": "Urothelial cells", "pct_positive": 9.741856177012908 }, { "count": 1087, "max": 2.8160624504089355, "mean": 0.04379236698150635, "name": "Natural killer T cells", "pct_positive": 2.2079116835326587 }, { "count": 149, "max": 2.5359091758728027, "mean": 0.03769947588443756, "name": "Connecting tubule cells", "pct_positive": 2.013422818791946 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "APOE", "name": "Apolipoprotein E", "overall": { "max": 5.592812538146973, "mean": 0.3858714699745178, "median": 0.0, "p95": 2.699561595916748, "pct_positive": 20.67703768624014 }, "pathway": "Lipid Metabolism", "pmid": "8136829", "q99_positive_species": 4.913139343261719, "source_symbol": "APOE", "symbol": "APOE", "tissue_stats": [ { "count": 12273, "max": 5.566500186920166, "mean": 0.8443927764892578, "name": "Kidney", "pct_positive": 39.631711887883974 }, { "count": 33367, "max": 5.592812538146973, "mean": 0.21721883118152618, "name": "Bladder", "pct_positive": 13.70515779063146 } ], "top_celltype": { "count": 696, "max": 5.016286849975586, "mean": 1.705432415008545, "name": "Intercalated cells", "pct_positive": 74.85632183908046 }, "top_tissue": { "count": 12273, "max": 5.566500186920166, "mean": 0.8443927764892578, "name": "Kidney", "pct_positive": 39.631711887883974 }, "vector_key": "APOE" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "FOXO3", "positive_n": 727901, "positive_pct": 58.401912762312804, "q99_positive": 3.682433843612671, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "FOXO3", "symbol": "FOXO3" }, "celltype_stats": [ { "count": 7317, "max": 5.373819828033447, "mean": 1.547241449356079, "name": "Macrophages", "pct_positive": 78.11944786114528 }, { "count": 1192, "max": 4.013637542724609, "mean": 1.5414948463439941, "name": "Monocytes", "pct_positive": 71.89597315436241 }, { "count": 13016, "max": 4.347404956817627, "mean": 0.8746815919876099, "name": "Urothelial cells", "pct_positive": 75.05377996312231 }, { "count": 2396, "max": 4.306438446044922, "mean": 0.8723387122154236, "name": "Smooth muscle cells", "pct_positive": 55.80133555926544 }, { "count": 8840, "max": 4.190467357635498, "mean": 0.6142079830169678, "name": "T cells", "pct_positive": 40.294117647058826 }, { "count": 761, "max": 2.491748094558716, "mean": 0.3924744129180908, "name": "Ascending loop of Henle cells", "pct_positive": 37.582128777923785 }, { "count": 2342, "max": 4.162689208984375, "mean": 0.3792421817779541, "name": "Endothelial cells", "pct_positive": 27.36976942783945 }, { "count": 489, "max": 2.6692280769348145, "mean": 0.3241085112094879, "name": "Fibroblasts", "pct_positive": 28.016359918200408 }, { "count": 1087, "max": 3.0579545497894287, "mean": 0.2893463671207428, "name": "Natural killer T cells", "pct_positive": 16.927322907083717 }, { "count": 5808, "max": 2.6131696701049805, "mean": 0.25757738947868347, "name": "Proximal tubule cells", "pct_positive": 31.11225895316804 }, { "count": 1484, "max": 2.929593801498413, "mean": 0.21097099781036377, "name": "Principal cells", "pct_positive": 20.350404312668463 }, { "count": 149, "max": 3.320228338241577, "mean": 0.20084431767463684, "name": "Connecting tubule cells", "pct_positive": 8.724832214765101 }, { "count": 63, "max": 2.4920871257781982, "mean": 0.19093529880046844, "name": "Podocytes", "pct_positive": 15.873015873015872 }, { "count": 696, "max": 1.9534912109375, "mean": 0.18242867290973663, "name": "Intercalated cells", "pct_positive": 21.695402298850574 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "FOXO3", "name": "Forkhead Box O3", "overall": { "max": 5.373819828033447, "mean": 0.782232403755188, "median": 0.48337796330451965, "p95": 2.5907506942749023, "pct_positive": 54.276950043821216 }, "pathway": "Insulin/IGF-1 Signaling", "pmid": "18765803", "q99_positive_species": 3.682433843612671, "source_symbol": "FOXO3", "symbol": "FOXO3", "tissue_stats": [ { "count": 33367, "max": 5.373819828033447, "mean": 0.9700485467910767, "name": "Bladder", "pct_positive": 64.21014775077171 }, { "count": 12273, "max": 3.320228338241577, "mean": 0.271610826253891, "name": "Kidney", "pct_positive": 27.27124582416687 } ], "top_celltype": { "count": 7317, "max": 5.373819828033447, "mean": 1.547241449356079, "name": "Macrophages", "pct_positive": 78.11944786114528 }, "top_tissue": { "count": 33367, "max": 5.373819828033447, "mean": 0.9700485467910767, "name": "Bladder", "pct_positive": 64.21014775077171 }, "vector_key": "FOXO3" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "CETP", "positive_n": 15958, "positive_pct": 1.2803632964661236, "q99_positive": 2.8351151943206787, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "CETP", "symbol": "CETP" }, "celltype_stats": [ { "count": 2342, "max": 2.788475275039673, "mean": 0.05541304871439934, "name": "Endothelial cells", "pct_positive": 4.782237403928266 }, { "count": 7317, "max": 3.026254892349243, "mean": 0.039742738008499146, "name": "Macrophages", "pct_positive": 3.8130381303813037 }, { "count": 1192, "max": 2.2610886096954346, "mean": 0.020965203642845154, "name": "Monocytes", "pct_positive": 2.2651006711409396 }, { "count": 489, "max": 1.9299668073654175, "mean": 0.011149291880428791, "name": "Fibroblasts", "pct_positive": 0.81799591002045 }, { "count": 13016, "max": 1.53879714012146, "mean": 0.0036111907102167606, "name": "Urothelial cells", "pct_positive": 0.53779963122311 }, { "count": 696, "max": 0.7236323952674866, "mean": 0.0025013319682329893, "name": "Intercalated cells", "pct_positive": 0.43103448275862066 }, { "count": 8840, "max": 1.5071179866790771, "mean": 0.0022729216143488884, "name": "T cells", "pct_positive": 0.2828054298642534 }, { "count": 2396, "max": 1.4777220487594604, "mean": 0.0012334060156717896, "name": "Smooth muscle cells", "pct_positive": 0.1669449081803005 }, { "count": 761, "max": 0.7137664556503296, "mean": 0.0009379322873428464, "name": "Ascending loop of Henle cells", "pct_positive": 0.1314060446780552 }, { "count": 1087, "max": 0.6530120968818665, "mean": 0.0006007471238262951, "name": "Natural killer T cells", "pct_positive": 0.09199632014719411 }, { "count": 5808, "max": 0.8075424432754517, "mean": 0.0001948881836142391, "name": "Proximal tubule cells", "pct_positive": 0.03443526170798898 }, { "count": 149, "max": 0.0, "mean": 0.0, "name": "Connecting tubule cells", "pct_positive": 0.0 }, { "count": 63, "max": 0.0, "mean": 0.0, "name": "Podocytes", "pct_positive": 0.0 }, { "count": 1484, "max": 0.0, "mean": 0.0, "name": "Principal cells", "pct_positive": 0.0 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "CETP", "name": "Cholesteryl Ester Transfer Protein", "overall": { "max": 3.026254892349243, "mean": 0.011509820818901062, "median": 0.0, "p95": 0.0, "pct_positive": 1.156879929886065 }, "pathway": "Lipid Metabolism", "pmid": "14559957", "q99_positive_species": 2.8351151943206787, "source_symbol": "CETP", "symbol": "CETP", "tissue_stats": [ { "count": 33367, "max": 3.026254892349243, "mean": 0.012467676773667336, "name": "Bladder", "pct_positive": 1.306680252944526 }, { "count": 12273, "max": 2.6166915893554688, "mean": 0.008905666880309582, "name": "Kidney", "pct_positive": 0.7496129715635949 } ], "top_celltype": { "count": 2342, "max": 2.788475275039673, "mean": 0.05541304871439934, "name": "Endothelial cells", "pct_positive": 4.782237403928266 }, "top_tissue": { "count": 33367, "max": 3.026254892349243, "mean": 0.012467676773667336, "name": "Bladder", "pct_positive": 1.306680252944526 }, "vector_key": "CETP" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "SIRT6", "positive_n": 94936, "positive_pct": 7.617030324182723, "q99_positive": 2.0462136268615723, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "SIRT6", "symbol": "SIRT6" }, "celltype_stats": [ { "count": 1484, "max": 2.622593402862549, "mean": 0.08537596464157104, "name": "Principal cells", "pct_positive": 8.827493261455526 }, { "count": 696, "max": 2.215202569961548, "mean": 0.07264197617769241, "name": "Intercalated cells", "pct_positive": 8.764367816091955 }, { "count": 5808, "max": 2.720268487930298, "mean": 0.0674998089671135, "name": "Proximal tubule cells", "pct_positive": 8.81542699724518 }, { "count": 761, "max": 1.5589345693588257, "mean": 0.06743539124727249, "name": "Ascending loop of Henle cells", "pct_positive": 8.409986859395532 }, { "count": 2342, "max": 2.474973440170288, "mean": 0.0671423003077507, "name": "Endothelial cells", "pct_positive": 6.063193851409053 }, { "count": 489, "max": 1.994592308998108, "mean": 0.0616019032895565, "name": "Fibroblasts", "pct_positive": 5.930470347648262 }, { "count": 7317, "max": 2.132383108139038, "mean": 0.05877676606178284, "name": "Macrophages", "pct_positive": 8.40508405084051 }, { "count": 13016, "max": 2.3340511322021484, "mean": 0.05612945556640625, "name": "Urothelial cells", "pct_positive": 11.42440073755378 }, { "count": 1192, "max": 1.980462908744812, "mean": 0.04377446323633194, "name": "Monocytes", "pct_positive": 4.865771812080537 }, { "count": 8840, "max": 2.4513890743255615, "mean": 0.036155540496110916, "name": "T cells", "pct_positive": 3.7104072398190047 }, { "count": 2396, "max": 2.3365800380706787, "mean": 0.035425666719675064, "name": "Smooth muscle cells", "pct_positive": 3.923205342237062 }, { "count": 1087, "max": 3.0715878009796143, "mean": 0.02951143868267536, "name": "Natural killer T cells", "pct_positive": 1.9319227230910765 }, { "count": 149, "max": 2.332369565963745, "mean": 0.028809694573283195, "name": "Connecting tubule cells", "pct_positive": 1.342281879194631 }, { "count": 63, "max": 0.0, "mean": 0.0, "name": "Podocytes", "pct_positive": 0.0 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "SIRT6", "name": "Sirtuin 6", "overall": { "max": 3.0715878009796143, "mean": 0.0539369136095047, "median": 0.0, "p95": 0.45405498147010803, "pct_positive": 7.765118317265557 }, "pathway": "Sirtuin Family", "pmid": "36215696", "q99_positive_species": 2.0462136268615723, "source_symbol": "SIRT6", "symbol": "SIRT6", "tissue_stats": [ { "count": 12273, "max": 2.720268487930298, "mean": 0.06869599223136902, "name": "Kidney", "pct_positive": 7.8790841684999595 }, { "count": 33367, "max": 3.0715878009796143, "mean": 0.048508256673812866, "name": "Bladder", "pct_positive": 7.723199568435881 } ], "top_celltype": { "count": 1484, "max": 2.622593402862549, "mean": 0.08537596464157104, "name": "Principal cells", "pct_positive": 8.827493261455526 }, "top_tissue": { "count": 12273, "max": 2.720268487930298, "mean": 0.06869599223136902, "name": "Kidney", "pct_positive": 7.8790841684999595 }, "vector_key": "SIRT6" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "SIRT1", "positive_n": 314865, "positive_pct": 25.262663826407195, "q99_positive": 2.3554694652557373, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "SIRT1", "symbol": "SIRT1" }, "celltype_stats": [ { "count": 7317, "max": 3.7816054821014404, "mean": 0.37448927760124207, "name": "Macrophages", "pct_positive": 37.41970753040864 }, { "count": 8840, "max": 3.2895302772521973, "mean": 0.2949773967266083, "name": "T cells", "pct_positive": 25.30542986425339 }, { "count": 13016, "max": 3.1843557357788086, "mean": 0.20702588558197021, "name": "Urothelial cells", "pct_positive": 32.75968039336202 }, { "count": 1192, "max": 2.393362283706665, "mean": 0.2065308690071106, "name": "Monocytes", "pct_positive": 21.140939597315437 }, { "count": 2396, "max": 2.5751638412475586, "mean": 0.20146164298057556, "name": "Smooth muscle cells", "pct_positive": 21.786310517529213 }, { "count": 1087, "max": 3.056988477706909, "mean": 0.15901078283786774, "name": "Natural killer T cells", "pct_positive": 10.763569457221712 }, { "count": 2342, "max": 2.6801278591156006, "mean": 0.13183926045894623, "name": "Endothelial cells", "pct_positive": 12.211784799316822 }, { "count": 63, "max": 1.4829660654067993, "mean": 0.11593566834926605, "name": "Podocytes", "pct_positive": 9.523809523809524 }, { "count": 489, "max": 2.0171380043029785, "mean": 0.10610194504261017, "name": "Fibroblasts", "pct_positive": 9.815950920245399 }, { "count": 5808, "max": 2.6309242248535156, "mean": 0.09217540174722672, "name": "Proximal tubule cells", "pct_positive": 12.792699724517906 }, { "count": 761, "max": 2.230621576309204, "mean": 0.07639075815677643, "name": "Ascending loop of Henle cells", "pct_positive": 9.198423127463863 }, { "count": 696, "max": 1.3344707489013672, "mean": 0.07480141520500183, "name": "Intercalated cells", "pct_positive": 9.913793103448276 }, { "count": 1484, "max": 2.6050076484680176, "mean": 0.07405909895896912, "name": "Principal cells", "pct_positive": 7.547169811320755 }, { "count": 149, "max": 2.7471773624420166, "mean": 0.05963410064578056, "name": "Connecting tubule cells", "pct_positive": 3.3557046979865772 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "SIRT1", "name": "Sirtuin 1", "overall": { "max": 3.7816054821014404, "mean": 0.22078029811382294, "median": 0.0, "p95": 1.262205719947815, "pct_positive": 25.12927256792287 }, "pathway": "Sirtuin Family", "pmid": "25793536", "q99_positive_species": 2.3554694652557373, "source_symbol": "SIRT1", "symbol": "SIRT1", "tissue_stats": [ { "count": 33367, "max": 3.7816054821014404, "mean": 0.26731011271476746, "name": "Bladder", "pct_positive": 30.25444301255732 }, { "count": 12273, "max": 2.7471773624420166, "mean": 0.09427814930677414, "name": "Kidney", "pct_positive": 11.195306770960645 } ], "top_celltype": { "count": 7317, "max": 3.7816054821014404, "mean": 0.37448927760124207, "name": "Macrophages", "pct_positive": 37.41970753040864 }, "top_tissue": { "count": 33367, "max": 3.7816054821014404, "mean": 0.26731011271476746, "name": "Bladder", "pct_positive": 30.25444301255732 }, "vector_key": "SIRT1" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "SIRT3", "positive_n": 125788, "positive_pct": 10.09238866624143, "q99_positive": 2.101539373397827, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "SIRT3", "symbol": "SIRT3" }, "celltype_stats": [ { "count": 761, "max": 1.676513433456421, "mean": 0.10451819002628326, "name": "Ascending loop of Henle cells", "pct_positive": 13.009198423127463 }, { "count": 696, "max": 1.8684042692184448, "mean": 0.10042664408683777, "name": "Intercalated cells", "pct_positive": 12.643678160919542 }, { "count": 1484, "max": 2.7071173191070557, "mean": 0.08521436899900436, "name": "Principal cells", "pct_positive": 9.366576819407008 }, { "count": 63, "max": 1.4829660654067993, "mean": 0.07982739806175232, "name": "Podocytes", "pct_positive": 6.349206349206349 }, { "count": 8840, "max": 2.852238893508911, "mean": 0.07335255295038223, "name": "T cells", "pct_positive": 7.149321266968325 }, { "count": 5808, "max": 2.862295150756836, "mean": 0.06924018263816833, "name": "Proximal tubule cells", "pct_positive": 9.400826446280993 }, { "count": 149, "max": 2.3807992935180664, "mean": 0.06087483838200569, "name": "Connecting tubule cells", "pct_positive": 3.3557046979865772 }, { "count": 2396, "max": 2.31491756439209, "mean": 0.05226324498653412, "name": "Smooth muscle cells", "pct_positive": 5.884808013355593 }, { "count": 2342, "max": 3.2010021209716797, "mean": 0.04837382212281227, "name": "Endothelial cells", "pct_positive": 4.312553373185312 }, { "count": 13016, "max": 2.4591774940490723, "mean": 0.046877577900886536, "name": "Urothelial cells", "pct_positive": 9.641979102642901 }, { "count": 1087, "max": 2.4024531841278076, "mean": 0.038295235484838486, "name": "Natural killer T cells", "pct_positive": 2.7598896044158234 }, { "count": 489, "max": 1.7781403064727783, "mean": 0.03593458980321884, "name": "Fibroblasts", "pct_positive": 4.08997955010225 }, { "count": 7317, "max": 2.4097979068756104, "mean": 0.03592757508158684, "name": "Macrophages", "pct_positive": 5.289052890528905 }, { "count": 1192, "max": 2.29461407661438, "mean": 0.022979607805609703, "name": "Monocytes", "pct_positive": 2.936241610738255 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "SIRT3", "name": "Sirtuin 3", "overall": { "max": 3.2010021209716797, "mean": 0.055624932050704956, "median": 0.0, "p95": 0.46800681948661804, "pct_positive": 7.629272567922875 }, "pathway": "Sirtuin Family", "pmid": "22234866", "q99_positive_species": 2.101539373397827, "source_symbol": "SIRT3", "symbol": "SIRT3", "tissue_stats": [ { "count": 12273, "max": 3.2010021209716797, "mean": 0.06874308735132217, "name": "Kidney", "pct_positive": 8.327222358021674 }, { "count": 33367, "max": 2.852238893508911, "mean": 0.050799835473299026, "name": "Bladder", "pct_positive": 7.372553720742051 } ], "top_celltype": { "count": 761, "max": 1.676513433456421, "mean": 0.10451819002628326, "name": "Ascending loop of Henle cells", "pct_positive": 13.009198423127463 }, "top_tissue": { "count": 12273, "max": 3.2010021209716797, "mean": 0.06874308735132217, "name": "Kidney", "pct_positive": 8.327222358021674 }, "vector_key": "SIRT3" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "IGF1R", "positive_n": 574396, "positive_pct": 46.08569720747935, "q99_positive": 3.4061527252197266, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "IGF1R", "symbol": "IGF1R" }, "celltype_stats": [ { "count": 13016, "max": 4.142385005950928, "mean": 1.1628607511520386, "name": "Urothelial cells", "pct_positive": 87.81499692685925 }, { "count": 2396, "max": 3.6842877864837646, "mean": 0.655344545841217, "name": "Smooth muscle cells", "pct_positive": 49.29048414023372 }, { "count": 63, "max": 2.395474433898926, "mean": 0.5066211223602295, "name": "Podocytes", "pct_positive": 34.92063492063492 }, { "count": 761, "max": 3.112727403640747, "mean": 0.4662524461746216, "name": "Ascending loop of Henle cells", "pct_positive": 43.62680683311432 }, { "count": 2342, "max": 3.7627642154693604, "mean": 0.34281501173973083, "name": "Endothelial cells", "pct_positive": 25.533731853116993 }, { "count": 1192, "max": 3.490593910217285, "mean": 0.29152190685272217, "name": "Monocytes", "pct_positive": 20.385906040268456 }, { "count": 5808, "max": 2.8922767639160156, "mean": 0.28716081380844116, "name": "Proximal tubule cells", "pct_positive": 31.663223140495866 }, { "count": 1484, "max": 3.298633575439453, "mean": 0.26147598028182983, "name": "Principal cells", "pct_positive": 23.921832884097036 }, { "count": 7317, "max": 2.899357557296753, "mean": 0.22985932230949402, "name": "Macrophages", "pct_positive": 23.219898865655324 }, { "count": 696, "max": 2.0521037578582764, "mean": 0.2111796736717224, "name": "Intercalated cells", "pct_positive": 25.0 }, { "count": 8840, "max": 3.473677396774292, "mean": 0.1881840080022812, "name": "T cells", "pct_positive": 14.558823529411766 }, { "count": 489, "max": 2.6214098930358887, "mean": 0.15864165127277374, "name": "Fibroblasts", "pct_positive": 14.723926380368098 }, { "count": 149, "max": 2.5521228313446045, "mean": 0.14040011167526245, "name": "Connecting tubule cells", "pct_positive": 8.053691275167784 }, { "count": 1087, "max": 2.585501194000244, "mean": 0.11905907839536667, "name": "Natural killer T cells", "pct_positive": 8.647654093836247 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "IGF1R", "name": "Insulin-like Growth Factor 1 Receptor", "overall": { "max": 4.142385005950928, "mean": 0.5262770056724548, "median": 0.0, "p95": 1.9888681173324585, "pct_positive": 42.370727432077125 }, "pathway": "Insulin/IGF-1 Signaling", "pmid": "12483226", "q99_positive_species": 3.4061527252197266, "source_symbol": "IGF1R", "symbol": "IGF1R", "tissue_stats": [ { "count": 33367, "max": 4.142385005950928, "mean": 0.6233455538749695, "name": "Bladder", "pct_positive": 48.32619054754698 }, { "count": 12273, "max": 3.298633575439453, "mean": 0.262373685836792, "name": "Kidney", "pct_positive": 26.17941823515033 } ], "top_celltype": { "count": 13016, "max": 4.142385005950928, "mean": 1.1628607511520386, "name": "Urothelial cells", "pct_positive": 87.81499692685925 }, "top_tissue": { "count": 33367, "max": 4.142385005950928, "mean": 0.6233455538749695, "name": "Bladder", "pct_positive": 48.32619054754698 }, "vector_key": "IGF1R" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "KL", "positive_n": 25561, "positive_pct": 2.0508438539272205, "q99_positive": 2.4546902179718018, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "KL", "symbol": "KLOTHO" }, "celltype_stats": [ { "count": 1484, "max": 3.712596893310547, "mean": 0.3272233307361603, "name": "Principal cells", "pct_positive": 24.797843665768195 }, { "count": 696, "max": 2.8269965648651123, "mean": 0.2869170606136322, "name": "Intercalated cells", "pct_positive": 26.00574712643678 }, { "count": 5808, "max": 2.8116421699523926, "mean": 0.2421819120645523, "name": "Proximal tubule cells", "pct_positive": 28.650137741046834 }, { "count": 761, "max": 2.785574436187744, "mean": 0.1535845696926117, "name": "Ascending loop of Henle cells", "pct_positive": 15.243101182654403 }, { "count": 489, "max": 1.9352717399597168, "mean": 0.10604772716760635, "name": "Fibroblasts", "pct_positive": 10.633946830265849 }, { "count": 2342, "max": 2.611999034881592, "mean": 0.09417159110307693, "name": "Endothelial cells", "pct_positive": 8.112724167378309 }, { "count": 63, "max": 1.412819504737854, "mean": 0.031853772699832916, "name": "Podocytes", "pct_positive": 3.1746031746031744 }, { "count": 149, "max": 1.9524528980255127, "mean": 0.02589362859725952, "name": "Connecting tubule cells", "pct_positive": 1.342281879194631 }, { "count": 7317, "max": 2.291411876678467, "mean": 0.015390933491289616, "name": "Macrophages", "pct_positive": 1.7766844335110017 }, { "count": 1192, "max": 1.540955901145935, "mean": 0.00972493551671505, "name": "Monocytes", "pct_positive": 1.006711409395973 }, { "count": 2396, "max": 1.9299668073654175, "mean": 0.007519952021539211, "name": "Smooth muscle cells", "pct_positive": 0.9181969949916527 }, { "count": 13016, "max": 1.5727137327194214, "mean": 0.006066263187676668, "name": "Urothelial cells", "pct_positive": 1.1370620774431468 }, { "count": 8840, "max": 1.9147677421569824, "mean": 0.002269814256578684, "name": "T cells", "pct_positive": 0.27149321266968324 }, { "count": 1087, "max": 0.0, "mean": 0.0, "name": "Natural killer T cells", "pct_positive": 0.0 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "KL", "name": "Klotho Anti-aging Protein", "overall": { "max": 3.712596893310547, "mean": 0.059778377413749695, "median": 0.0, "p95": 0.5345726609230042, "pct_positive": 6.378177037686241 }, "pathway": "Anti-aging", "pmid": "30633899", "q99_positive_species": 2.4546902179718018, "source_symbol": "KL", "symbol": "KLOTHO", "tissue_stats": [ { "count": 12273, "max": 3.712596893310547, "mean": 0.19984745979309082, "name": "Kidney", "pct_positive": 20.67139248757435 }, { "count": 33367, "max": 2.441993236541748, "mean": 0.008258381858468056, "name": "Bladder", "pct_positive": 1.1208679233973686 } ], "top_celltype": { "count": 1484, "max": 3.712596893310547, "mean": 0.3272233307361603, "name": "Principal cells", "pct_positive": 24.797843665768195 }, "top_tissue": { "count": 12273, "max": 3.712596893310547, "mean": 0.19984745979309082, "name": "Kidney", "pct_positive": 20.67139248757435 }, "vector_key": "KLOTHO" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "APOC3", "positive_n": 22296, "positive_pct": 1.7888820690568172, "q99_positive": 6.765168190002441, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "APOC3", "symbol": "APOC3" }, "celltype_stats": [ { "count": 5808, "max": 2.5532147884368896, "mean": 0.030751151964068413, "name": "Proximal tubule cells", "pct_positive": 2.479338842975207 }, { "count": 489, "max": 1.7059354782104492, "mean": 0.0034886205103248358, "name": "Fibroblasts", "pct_positive": 0.2044989775051125 }, { "count": 761, "max": 1.8865777254104614, "mean": 0.002479077083989978, "name": "Ascending loop of Henle cells", "pct_positive": 0.1314060446780552 }, { "count": 2342, "max": 2.2470974922180176, "mean": 0.002366722095757723, "name": "Endothelial cells", "pct_positive": 0.1707941929974381 }, { "count": 696, "max": 0.9210571050643921, "mean": 0.0020700141321867704, "name": "Intercalated cells", "pct_positive": 0.28735632183908044 }, { "count": 1484, "max": 1.1302517652511597, "mean": 0.0012120294850319624, "name": "Principal cells", "pct_positive": 0.13477088948787064 }, { "count": 7317, "max": 1.2221965789794922, "mean": 0.0003223043750040233, "name": "Macrophages", "pct_positive": 0.027333606669400025 }, { "count": 8840, "max": 1.019041657447815, "mean": 0.00020964078430552036, "name": "T cells", "pct_positive": 0.02262443438914027 }, { "count": 149, "max": 0.0, "mean": 0.0, "name": "Connecting tubule cells", "pct_positive": 0.0 }, { "count": 1192, "max": 0.0, "mean": 0.0, "name": "Monocytes", "pct_positive": 0.0 }, { "count": 1087, "max": 0.0, "mean": 0.0, "name": "Natural killer T cells", "pct_positive": 0.0 }, { "count": 63, "max": 0.0, "mean": 0.0, "name": "Podocytes", "pct_positive": 0.0 }, { "count": 2396, "max": 0.0, "mean": 0.0, "name": "Smooth muscle cells", "pct_positive": 0.0 }, { "count": 13016, "max": 0.0, "mean": 0.0, "name": "Urothelial cells", "pct_positive": 0.0 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "APOC3", "name": "Apolipoprotein C-III", "overall": { "max": 2.5532147884368896, "mean": 0.004276708699762821, "median": 0.0, "p95": 0.0, "pct_positive": 0.34618755477651186 }, "pathway": "Lipid Metabolism", "pmid": "16602826", "q99_positive_species": 6.765168190002441, "source_symbol": "APOC3", "symbol": "APOC3", "tissue_stats": [ { "count": 12273, "max": 2.5532147884368896, "mean": 0.015835965052247047, "name": "Kidney", "pct_positive": 1.279230831907439 }, { "count": 33367, "max": 0.8341829180717468, "mean": 2.5000237656058744e-05, "name": "Bladder", "pct_positive": 0.002996973057212216 } ], "top_celltype": { "count": 5808, "max": 2.5532147884368896, "mean": 0.030751151964068413, "name": "Proximal tubule cells", "pct_positive": 2.479338842975207 }, "top_tissue": { "count": 12273, "max": 2.5532147884368896, "mean": 0.015835965052247047, "name": "Kidney", "pct_positive": 1.279230831907439 }, "vector_key": "APOC3" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "IL6", "positive_n": 69252, "positive_pct": 5.556317772081212, "q99_positive": 4.358819484710693, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "IL6", "symbol": "IL6" }, "celltype_stats": [ { "count": 2396, "max": 4.539656162261963, "mean": 0.41476643085479736, "name": "Smooth muscle cells", "pct_positive": 21.953255425709518 }, { "count": 1192, "max": 3.6028764247894287, "mean": 0.3424290716648102, "name": "Monocytes", "pct_positive": 22.14765100671141 }, { "count": 2342, "max": 4.637713432312012, "mean": 0.22557291388511658, "name": "Endothelial cells", "pct_positive": 11.058923996584117 }, { "count": 7317, "max": 3.7560107707977295, "mean": 0.151619553565979, "name": "Macrophages", "pct_positive": 12.272789394560613 }, { "count": 489, "max": 4.011305332183838, "mean": 0.05789787694811821, "name": "Fibroblasts", "pct_positive": 3.476482617586912 }, { "count": 8840, "max": 2.9289331436157227, "mean": 0.030832616612315178, "name": "T cells", "pct_positive": 2.7828054298642533 }, { "count": 13016, "max": 2.4369773864746094, "mean": 0.01597064547240734, "name": "Urothelial cells", "pct_positive": 2.1742470805162877 }, { "count": 149, "max": 2.0859436988830566, "mean": 0.01399962231516838, "name": "Connecting tubule cells", "pct_positive": 0.6711409395973155 }, { "count": 1484, "max": 1.2169849872589111, "mean": 0.008794886991381645, "name": "Principal cells", "pct_positive": 1.078167115902965 }, { "count": 5808, "max": 2.5521228313446045, "mean": 0.0054430533200502396, "name": "Proximal tubule cells", "pct_positive": 0.46487603305785125 }, { "count": 1087, "max": 1.8035223484039307, "mean": 0.004731916822493076, "name": "Natural killer T cells", "pct_positive": 0.36798528058877644 }, { "count": 761, "max": 0.5931702852249146, "mean": 0.0007794615812599659, "name": "Ascending loop of Henle cells", "pct_positive": 0.1314060446780552 }, { "count": 696, "max": 0.37703773379325867, "mean": 0.0005417208885774016, "name": "Intercalated cells", "pct_positive": 0.14367816091954022 }, { "count": 63, "max": 0.0, "mean": 0.0, "name": "Podocytes", "pct_positive": 0.0 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "IL6", "name": "Interleukin 6", "overall": { "max": 4.637713432312012, "mean": 0.07890576124191284, "median": 0.0, "p95": 0.45003220438957214, "pct_positive": 5.571866783523225 }, "pathway": "Inflammation", "pmid": "22234866", "q99_positive_species": 4.358819484710693, "source_symbol": "IL6", "symbol": "IL6", "tissue_stats": [ { "count": 33367, "max": 4.637713432312012, "mean": 0.10446753352880478, "name": "Bladder", "pct_positive": 7.35756885545599 }, { "count": 12273, "max": 4.011305332183838, "mean": 0.009410099126398563, "name": "Kidney", "pct_positive": 0.717021103234743 } ], "top_celltype": { "count": 2396, "max": 4.539656162261963, "mean": 0.41476643085479736, "name": "Smooth muscle cells", "pct_positive": 21.953255425709518 }, "top_tissue": { "count": 33367, "max": 4.637713432312012, "mean": 0.10446753352880478, "name": "Bladder", "pct_positive": 7.35756885545599 }, "vector_key": "IL6" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "TERT", "positive_n": 2751, "positive_pct": 0.22072185916645606, "q99_positive": 1.945739507675171, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "TERT", "symbol": "TERT" }, "celltype_stats": [ { "count": 8840, "max": 1.3411043882369995, "mean": 0.0004035859601572156, "name": "T cells", "pct_positive": 0.056561085972850686 }, { "count": 13016, "max": 1.274428129196167, "mean": 0.0003140167682431638, "name": "Urothelial cells", "pct_positive": 0.046097111247695145 }, { "count": 2396, "max": 0.48577237129211426, "mean": 0.00020274306007195264, "name": "Smooth muscle cells", "pct_positive": 0.041736227045075125 }, { "count": 7317, "max": 0.8105831742286682, "mean": 0.0001889347331598401, "name": "Macrophages", "pct_positive": 0.027333606669400025 }, { "count": 761, "max": 0.0, "mean": 0.0, "name": "Ascending loop of Henle cells", "pct_positive": 0.0 }, { "count": 149, "max": 0.0, "mean": 0.0, "name": "Connecting tubule cells", "pct_positive": 0.0 }, { "count": 2342, "max": 0.0, "mean": 0.0, "name": "Endothelial cells", "pct_positive": 0.0 }, { "count": 489, "max": 0.0, "mean": 0.0, "name": "Fibroblasts", "pct_positive": 0.0 }, { "count": 696, "max": 0.0, "mean": 0.0, "name": "Intercalated cells", "pct_positive": 0.0 }, { "count": 1192, "max": 0.0, "mean": 0.0, "name": "Monocytes", "pct_positive": 0.0 }, { "count": 1087, "max": 0.0, "mean": 0.0, "name": "Natural killer T cells", "pct_positive": 0.0 }, { "count": 63, "max": 0.0, "mean": 0.0, "name": "Podocytes", "pct_positive": 0.0 }, { "count": 1484, "max": 0.0, "mean": 0.0, "name": "Principal cells", "pct_positive": 0.0 }, { "count": 5808, "max": 0.0, "mean": 0.0, "name": "Proximal tubule cells", "pct_positive": 0.0 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "TERT", "name": "Telomerase Reverse Transcriptase", "overall": { "max": 1.3411043882369995, "mean": 0.00020865799160674214, "median": 0.0, "p95": 0.0, "pct_positive": 0.030674846625766874 }, "pathway": "Telomere Maintenance", "pmid": "39132489", "q99_positive_species": 1.945739507675171, "source_symbol": "TERT", "symbol": "TERT", "tissue_stats": [ { "count": 33367, "max": 1.3411043882369995, "mean": 0.00028540624771267176, "name": "Bladder", "pct_positive": 0.04195762280097102 }, { "count": 12273, "max": 0.0, "mean": 0.0, "name": "Kidney", "pct_positive": 0.0 } ], "top_celltype": { "count": 8840, "max": 1.3411043882369995, "mean": 0.0004035859601572156, "name": "T cells", "pct_positive": 0.056561085972850686 }, "top_tissue": { "count": 33367, "max": 1.3411043882369995, "mean": 0.00028540624771267176, "name": "Bladder", "pct_positive": 0.04195762280097102 }, "vector_key": "TERT" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "IRS2", "positive_n": 426152, "positive_pct": 34.19158914122268, "q99_positive": 3.3082995414733887, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "IRS2", "symbol": "IRS2" }, "celltype_stats": [ { "count": 1192, "max": 4.212543487548828, "mean": 0.8775171041488647, "name": "Monocytes", "pct_positive": 53.7751677852349 }, { "count": 7317, "max": 4.142911434173584, "mean": 0.8127486705780029, "name": "Macrophages", "pct_positive": 61.746617466174655 }, { "count": 8840, "max": 3.683884620666504, "mean": 0.3914870023727417, "name": "T cells", "pct_positive": 29.773755656108598 }, { "count": 13016, "max": 2.61586856842041, "mean": 0.25496891140937805, "name": "Urothelial cells", "pct_positive": 38.40657652120467 }, { "count": 2396, "max": 2.2627580165863037, "mean": 0.21972279250621796, "name": "Smooth muscle cells", "pct_positive": 24.207011686143574 }, { "count": 1087, "max": 2.967467784881592, "mean": 0.21492193639278412, "name": "Natural killer T cells", "pct_positive": 13.431462741490341 }, { "count": 761, "max": 2.4523584842681885, "mean": 0.1705773025751114, "name": "Ascending loop of Henle cells", "pct_positive": 18.134034165571617 }, { "count": 1484, "max": 2.534304618835449, "mean": 0.14518366754055023, "name": "Principal cells", "pct_positive": 14.555256064690028 }, { "count": 696, "max": 2.0012032985687256, "mean": 0.13838239014148712, "name": "Intercalated cells", "pct_positive": 16.954022988505745 }, { "count": 489, "max": 2.2854411602020264, "mean": 0.11905215680599213, "name": "Fibroblasts", "pct_positive": 10.429447852760736 }, { "count": 5808, "max": 2.6852047443389893, "mean": 0.06695188581943512, "name": "Proximal tubule cells", "pct_positive": 9.50413223140496 }, { "count": 2342, "max": 2.4809741973876953, "mean": 0.039924100041389465, "name": "Endothelial cells", "pct_positive": 4.44064901793339 }, { "count": 63, "max": 1.6059272289276123, "mean": 0.025490907952189445, "name": "Podocytes", "pct_positive": 1.5873015873015872 }, { "count": 149, "max": 1.431680679321289, "mean": 0.017440911382436752, "name": "Connecting tubule cells", "pct_positive": 1.342281879194631 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "IRS2", "name": "Insulin Receptor Substrate 2", "overall": { "max": 4.212543487548828, "mean": 0.34002485871315, "median": 0.0, "p95": 1.6544382572174072, "pct_positive": 32.20420683610868 }, "pathway": "Insulin/IGF-1 Signaling", "pmid": "19887537", "q99_positive_species": 3.3082995414733887, "source_symbol": "IRS2", "symbol": "IRS2", "tissue_stats": [ { "count": 33367, "max": 4.212543487548828, "mean": 0.4226347804069519, "name": "Bladder", "pct_positive": 39.584020139658946 }, { "count": 12273, "max": 3.375737190246582, "mean": 0.11543060094118118, "name": "Kidney", "pct_positive": 12.140470952497353 } ], "top_celltype": { "count": 1192, "max": 4.212543487548828, "mean": 0.8775171041488647, "name": "Monocytes", "pct_positive": 53.7751677852349 }, "top_tissue": { "count": 33367, "max": 4.212543487548828, "mean": 0.4226347804069519, "name": "Bladder", "pct_positive": 39.584020139658946 }, "vector_key": "IRS2" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "TP53", "positive_n": 170394, "positive_pct": 13.671276070813926, "q99_positive": 2.170886993408203, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "TP53", "symbol": "TP53" }, "celltype_stats": [ { "count": 13016, "max": 2.2298805713653564, "mean": 0.1614542305469513, "name": "Urothelial cells", "pct_positive": 29.701905347264905 }, { "count": 1484, "max": 2.953101634979248, "mean": 0.15115498006343842, "name": "Principal cells", "pct_positive": 16.307277628032345 }, { "count": 2342, "max": 2.8249692916870117, "mean": 0.14944763481616974, "name": "Endothelial cells", "pct_positive": 12.980358667805294 }, { "count": 761, "max": 2.3067355155944824, "mean": 0.1425504982471466, "name": "Ascending loop of Henle cells", "pct_positive": 15.637319316688567 }, { "count": 489, "max": 2.7791757583618164, "mean": 0.1374252736568451, "name": "Fibroblasts", "pct_positive": 12.269938650306749 }, { "count": 7317, "max": 2.18033766746521, "mean": 0.12655863165855408, "name": "Macrophages", "pct_positive": 16.728167281672818 }, { "count": 696, "max": 2.2065227031707764, "mean": 0.12337101250886917, "name": "Intercalated cells", "pct_positive": 15.517241379310345 }, { "count": 5808, "max": 2.72959303855896, "mean": 0.1035289317369461, "name": "Proximal tubule cells", "pct_positive": 14.118457300275484 }, { "count": 8840, "max": 2.7887911796569824, "mean": 0.09740862995386124, "name": "T cells", "pct_positive": 9.468325791855204 }, { "count": 149, "max": 2.0810182094573975, "mean": 0.0771108865737915, "name": "Connecting tubule cells", "pct_positive": 4.697986577181208 }, { "count": 1192, "max": 2.393362283706665, "mean": 0.07604869455099106, "name": "Monocytes", "pct_positive": 9.479865771812081 }, { "count": 1087, "max": 2.489041805267334, "mean": 0.07376264035701752, "name": "Natural killer T cells", "pct_positive": 5.519779208831647 }, { "count": 2396, "max": 2.2343366146087646, "mean": 0.07035097479820251, "name": "Smooth muscle cells", "pct_positive": 8.180300500834726 }, { "count": 63, "max": 1.1891072988510132, "mean": 0.034441784024238586, "name": "Podocytes", "pct_positive": 3.1746031746031744 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "TP53", "name": "Tumor Protein P53", "overall": { "max": 2.953101634979248, "mean": 0.12442648410797119, "median": 0.0, "p95": 0.8387053608894348, "pct_positive": 17.436459246275195 }, "pathway": "Tumor Suppression", "pmid": "17667954", "q99_positive_species": 2.170886993408203, "source_symbol": "TP53", "symbol": "TP53", "tissue_stats": [ { "count": 12273, "max": 2.953101634979248, "mean": 0.12646502256393433, "name": "Kidney", "pct_positive": 14.218202558461664 }, { "count": 33367, "max": 2.8249692916870117, "mean": 0.12367668002843857, "name": "Bladder", "pct_positive": 18.620193604459494 } ], "top_celltype": { "count": 13016, "max": 2.2298805713653564, "mean": 0.1614542305469513, "name": "Urothelial cells", "pct_positive": 29.701905347264905 }, "top_tissue": { "count": 12273, "max": 2.953101634979248, "mean": 0.12646502256393433, "name": "Kidney", "pct_positive": 14.218202558461664 }, "vector_key": "TP53" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "SHC1", "positive_n": 172211, "positive_pct": 13.817060010510565, "q99_positive": 2.1945977210998535, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "SHC1", "symbol": "SHC1" }, "celltype_stats": [ { "count": 2342, "max": 3.9735679626464844, "mean": 0.5273606181144714, "name": "Endothelial cells", "pct_positive": 34.92741246797609 }, { "count": 489, "max": 2.617868661880493, "mean": 0.24478159844875336, "name": "Fibroblasts", "pct_positive": 21.676891615541923 }, { "count": 63, "max": 2.7163023948669434, "mean": 0.2326914221048355, "name": "Podocytes", "pct_positive": 17.46031746031746 }, { "count": 2396, "max": 2.7848610877990723, "mean": 0.2204103022813797, "name": "Smooth muscle cells", "pct_positive": 23.247078464106842 }, { "count": 13016, "max": 2.3340511322021484, "mean": 0.213077574968338, "name": "Urothelial cells", "pct_positive": 38.621696373693915 }, { "count": 761, "max": 2.2701191902160645, "mean": 0.13383418321609497, "name": "Ascending loop of Henle cells", "pct_positive": 15.637319316688567 }, { "count": 696, "max": 1.63554048538208, "mean": 0.11993417143821716, "name": "Intercalated cells", "pct_positive": 14.942528735632186 }, { "count": 1484, "max": 3.0256717205047607, "mean": 0.1156105101108551, "name": "Principal cells", "pct_positive": 11.859838274932615 }, { "count": 5808, "max": 2.681394100189209, "mean": 0.10879428684711456, "name": "Proximal tubule cells", "pct_positive": 14.789944903581267 }, { "count": 7317, "max": 2.3897533416748047, "mean": 0.1070479303598404, "name": "Macrophages", "pct_positive": 15.006150061500614 }, { "count": 1192, "max": 2.432227849960327, "mean": 0.08065353333950043, "name": "Monocytes", "pct_positive": 9.312080536912752 }, { "count": 1087, "max": 2.470996618270874, "mean": 0.07494985312223434, "name": "Natural killer T cells", "pct_positive": 4.875804967801288 }, { "count": 8840, "max": 2.7791757583618164, "mean": 0.06782497465610504, "name": "T cells", "pct_positive": 6.877828054298643 }, { "count": 149, "max": 2.7471773624420166, "mean": 0.06412188708782196, "name": "Connecting tubule cells", "pct_positive": 3.3557046979865772 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "SHC1", "name": "SHC Adaptor Protein 1", "overall": { "max": 3.9735679626464844, "mean": 0.15840771794319153, "median": 0.0, "p95": 0.9447292685508728, "pct_positive": 21.148115687992988 }, "pathway": "Signal Transduction", "pmid": "14530863", "q99_positive_species": 2.1945977210998535, "source_symbol": "SHC1", "symbol": "SHC1", "tissue_stats": [ { "count": 33367, "max": 3.2744662761688232, "mean": 0.15853311121463776, "name": "Bladder", "pct_positive": 23.178589624479276 }, { "count": 12273, "max": 3.9735679626464844, "mean": 0.15806680917739868, "name": "Kidney", "pct_positive": 15.62780086368451 } ], "top_celltype": { "count": 2342, "max": 3.9735679626464844, "mean": 0.5273606181144714, "name": "Endothelial cells", "pct_positive": 34.92741246797609 }, "top_tissue": { "count": 33367, "max": 3.2744662761688232, "mean": 0.15853311121463776, "name": "Bladder", "pct_positive": 23.178589624479276 }, "vector_key": "SHC1" }, { "calibration": { "fallback_reason": null, "fallback_used": false, "matrix_symbol": "ACE", "positive_n": 40647, "positive_pct": 3.261243696669916, "q99_positive": 2.4906063079833984, "quantile_method": "linear", "reference_n_cells": 1246365, "source_symbol": "ACE", "symbol": "ACE" }, "celltype_stats": [ { "count": 2342, "max": 2.777053117752075, "mean": 0.062095727771520615, "name": "Endothelial cells", "pct_positive": 5.2946199829205804 }, { "count": 63, "max": 1.412819504737854, "mean": 0.03836934641003609, "name": "Podocytes", "pct_positive": 3.1746031746031744 }, { "count": 5808, "max": 1.57150399684906, "mean": 0.026233231648802757, "name": "Proximal tubule cells", "pct_positive": 4.115013774104683 }, { "count": 7317, "max": 1.6327184438705444, "mean": 0.021279703825712204, "name": "Macrophages", "pct_positive": 3.293699603662703 }, { "count": 1484, "max": 2.622593402862549, "mean": 0.012451720423996449, "name": "Principal cells", "pct_positive": 1.1455525606469004 }, { "count": 489, "max": 1.4533953666687012, "mean": 0.01235899981111288, "name": "Fibroblasts", "pct_positive": 1.4314928425357873 }, { "count": 1192, "max": 2.104696273803711, "mean": 0.008098432794213295, "name": "Monocytes", "pct_positive": 0.8389261744966443 }, { "count": 1087, "max": 2.47597074508667, "mean": 0.00658595422282815, "name": "Natural killer T cells", "pct_positive": 0.27598896044158233 }, { "count": 13016, "max": 1.5071179866790771, "mean": 0.006250255275517702, "name": "Urothelial cells", "pct_positive": 1.3368162261831593 }, { "count": 8840, "max": 1.9052107334136963, "mean": 0.005919771268963814, "name": "T cells", "pct_positive": 0.6787330316742082 }, { "count": 2396, "max": 1.6103986501693726, "mean": 0.0026914894115179777, "name": "Smooth muscle cells", "pct_positive": 0.333889816360601 }, { "count": 696, "max": 0.5619507431983948, "mean": 0.00127526861615479, "name": "Intercalated cells", "pct_positive": 0.28735632183908044 }, { "count": 761, "max": 0.5846396684646606, "mean": 0.0007682518917135894, "name": "Ascending loop of Henle cells", "pct_positive": 0.1314060446780552 }, { "count": 149, "max": 0.0, "mean": 0.0, "name": "Connecting tubule cells", "pct_positive": 0.0 } ], "mapping_method": "case_insensitive_exact", "matrix_symbol": "ACE", "name": "Angiotensin-Converting Enzyme", "overall": { "max": 2.777053117752075, "mean": 0.013997610658407211, "median": 0.0, "p95": 0.0, "pct_positive": 1.9456617002629275 }, "pathway": "Signal Transduction", "pmid": "16463022", "q99_positive_species": 2.4906063079833984, "source_symbol": "ACE", "symbol": "ACE", "tissue_stats": [ { "count": 12273, "max": 2.777053117752075, "mean": 0.021932637318968773, "name": "Kidney", "pct_positive": 2.745864906705777 }, { "count": 33367, "max": 2.7547240257263184, "mean": 0.011078961193561554, "name": "Bladder", "pct_positive": 1.651332154523931 } ], "top_celltype": { "count": 2342, "max": 2.777053117752075, "mean": 0.062095727771520615, "name": "Endothelial cells", "pct_positive": 5.2946199829205804 }, "top_tissue": { "count": 12273, "max": 2.777053117752075, "mean": 0.021932637318968773, "name": "Kidney", "pct_positive": 2.745864906705777 }, "vector_key": "ACE" } ], "interpretation": "Descriptive relative-expression scores only. Compare scores only within the same source species and an identical mapped gene set. Higher expression scores do not imply a pro-longevity direction, and these results do not establish causality.", "method_status": "validated_real", "schema_version": "2.0", "signature": { "coverage_status": "full", "denominator_gene_count": 15, "gene_set_id": "LACA-LONGEVITY-15-v1", "mapped_count": 15, "mapped_genes": [ "APOE", "FOXO3", "CETP", "SIRT6", "SIRT1", "SIRT3", "IGF1R", "KLOTHO", "APOC3", "IL6", "TERT", "IRS2", "TP53", "SHC1", "ACE" ], "mapping_method": "case_insensitive_exact", "missing_gene_handling": "none_missing", "missing_genes": [], "ortholog_inference": false, "score_basis": "all_curated_genes", "total_genes": 15 }, "status": "available" }