/*
 * Study-wide, source-record, and native-expression views for the 41-mammal
 * longevity RNA-seq manifest. No third-party UI or chart dependency is used.
 */

.msa-page {
    --msa-green: #45f0a5;
    --msa-cyan: #5edcff;
    --msa-violet: #a88aff;
    --msa-pink: #ff78c8;
    --msa-amber: #ffd166;
    --msa-surface: rgba(7, 2, 23, 0.9);
    --msa-surface-soft: rgba(18, 7, 43, 0.76);
    --msa-border: rgba(255, 255, 255, 0.12);
    width: min(1500px, calc(100% - 2rem));
    max-width: none;
    padding-top: clamp(1.25rem, 3vw, 3rem);
}

.msa-page [hidden] {
    display: none !important;
}

.msa-page a,
.msa-page button,
.msa-page input,
.msa-page select {
    outline: none;
}

.msa-page a:focus-visible,
.msa-page button:focus-visible,
.msa-page input:focus-visible,
.msa-page select:focus-visible,
.msa-page [tabindex="0"]:focus-visible {
    outline: 3px solid var(--msa-cyan);
    outline-offset: 3px;
}

.msa-breadcrumb {
    display: flex;
    flex-wrap: wrap;
    gap: 0.45rem;
    margin: 0 0 1rem;
    color: rgba(239, 236, 255, 0.5);
    font: 700 0.7rem/1.5 "JetBrains Mono", monospace;
    letter-spacing: 0.06em;
    text-transform: uppercase;
}

.msa-breadcrumb a {
    color: var(--msa-green);
    text-decoration: none;
}

.msa-breadcrumb a:hover {
    text-decoration: underline;
    text-underline-offset: 0.25rem;
}

.msa-hero,
.msa-source-hero,
.msa-native-hero {
    display: grid;
    grid-template-columns: minmax(0, 1fr) minmax(250px, 0.34fr);
    align-items: end;
    gap: clamp(1.5rem, 4vw, 4rem);
    padding: clamp(1.7rem, 4.5vw, 4.25rem);
    background:
        radial-gradient(circle at 88% 8%, rgba(69, 240, 165, 0.18), transparent 30%),
        radial-gradient(circle at 74% 100%, rgba(94, 220, 255, 0.1), transparent 38%),
        linear-gradient(135deg, rgba(17, 5, 42, 0.98), rgba(5, 1, 19, 0.93));
}

.msa-hero h1,
.msa-source-hero h1,
.msa-native-hero h1 {
    font-size: clamp(2.15rem, 5vw, 4.75rem);
}

.msa-hero-ledger,
.msa-source-ledger,
.msa-native-ledger {
    position: relative;
    z-index: 2;
    display: grid;
    gap: 0.65rem;
    margin: 0;
}

.msa-hero-ledger div,
.msa-source-ledger div,
.msa-native-ledger div {
    display: flex;
    align-items: baseline;
    justify-content: space-between;
    gap: 1rem;
    min-width: 0;
    padding: 0.9rem 1rem;
    border: 1px solid rgba(255, 255, 255, 0.1);
    border-radius: 12px;
    background: rgba(4, 1, 15, 0.64);
}

.msa-hero-ledger dt,
.msa-source-ledger dt,
.msa-native-ledger dt {
    color: rgba(255, 255, 255, 0.58);
    font-size: 0.68rem;
    text-transform: uppercase;
    letter-spacing: 0.08em;
}

.msa-hero-ledger dd,
.msa-source-ledger dd,
.msa-native-ledger dd {
    min-width: 0;
    margin: 0;
    color: var(--msa-green);
    font: 800 clamp(1rem, 2.4vw, 1.55rem)/1.2 "Orbitron", sans-serif;
    overflow-wrap: anywhere;
}

.msa-native-ledger dd.is-unit {
    max-width: 18ch;
    font: 700 0.8rem/1.4 "JetBrains Mono", monospace;
    text-align: right;
}

.msa-boundary,
.msa-native-warning {
    margin-top: 1rem;
    padding: 1rem 1.2rem;
    font-size: 0.77rem;
    line-height: 1.75;
}

.msa-boundary strong,
.msa-native-warning strong {
    color: var(--msa-green);
}

.msa-native-warning {
    border-color: rgba(255, 209, 102, 0.38);
    border-left-color: var(--msa-amber);
    background: linear-gradient(90deg, rgba(255, 209, 102, 0.1), rgba(8, 2, 24, 0.88));
}

.msa-native-warning strong {
    color: var(--msa-amber);
}

.msa-tissue-grid {
    display: grid;
    grid-template-columns: repeat(3, minmax(0, 1fr));
    gap: 0.85rem;
}

.msa-tissue-card {
    display: grid;
    grid-template-columns: 104px minmax(0, 1fr);
    align-items: center;
    gap: 1rem;
    min-width: 0;
    padding: 1rem;
    border: 1px solid var(--msa-border);
    border-radius: 17px;
    background:
        radial-gradient(circle at 5% 50%, rgba(69, 240, 165, 0.09), transparent 46%),
        var(--msa-surface);
    transition: transform 180ms ease, border-color 180ms ease;
}

.msa-tissue-card:hover {
    transform: translateY(-3px);
    border-color: rgba(69, 240, 165, 0.38);
}

.msa-tissue-visual {
    display: grid;
    place-items: center;
    aspect-ratio: 1;
    overflow: hidden;
    border: 1px solid rgba(255, 255, 255, 0.1);
    border-radius: 13px;
    background: rgba(255, 255, 255, 0.92);
}

.msa-tissue-visual img {
    width: 86%;
    height: 86%;
    object-fit: contain;
}

.msa-tissue-copy {
    min-width: 0;
}

.msa-tissue-copy h3,
.msa-source-tissue-card h3 {
    margin: 0;
    color: #fff;
    font: 800 0.94rem/1.35 "Orbitron", sans-serif;
}

.msa-tissue-copy p,
.msa-source-tissue-card p {
    margin: 0.45rem 0 0;
    color: rgba(255, 255, 255, 0.6);
    font-size: 0.72rem;
}

.msa-tissue-copy p strong,
.msa-source-tissue-card p strong {
    color: var(--msa-green);
    font-size: 1.05rem;
}

.msa-meter,
.msa-result-bar {
    display: block;
    height: 5px;
    overflow: hidden;
    margin-top: 0.65rem;
    border-radius: 999px;
    background: rgba(255, 255, 255, 0.08);
}

.msa-meter i,
.msa-result-bar i {
    display: block;
    width: var(--msa-value, 0%);
    height: 100%;
    border-radius: inherit;
    background: linear-gradient(90deg, var(--msa-green), var(--msa-cyan));
    box-shadow: 0 0 12px rgba(69, 240, 165, 0.42);
}

.msa-tissue-copy a {
    display: inline-block;
    margin-top: 0.65rem;
    color: var(--msa-green);
    font-size: 0.67rem;
    font-weight: 800;
    text-decoration: none;
}

.msa-tissue-copy a:hover {
    text-decoration: underline;
    text-underline-offset: 0.22rem;
}

.msa-asset-note {
    margin: 0.8rem 0 0;
    color: rgba(255, 255, 255, 0.42);
    font-size: 0.66rem;
    line-height: 1.65;
}

.msa-filter-panel {
    display: grid;
    grid-template-columns: minmax(260px, 1.35fr) minmax(190px, 0.7fr) minmax(190px, 0.7fr) auto;
    gap: 0.75rem;
    align-items: end;
    padding: 1rem;
    border: 1px solid var(--msa-border);
    border-radius: 16px 16px 0 0;
    background: rgba(7, 2, 23, 0.94);
}

.msa-filter-panel label {
    display: grid;
    gap: 0.42rem;
    min-width: 0;
    color: rgba(255, 255, 255, 0.58);
    font-size: 0.65rem;
    font-weight: 800;
    letter-spacing: 0.06em;
    text-transform: uppercase;
}

.msa-filter-panel input,
.msa-filter-panel select {
    width: 100%;
    min-height: 46px;
    padding: 0.68rem 0.78rem;
    border: 1px solid rgba(255, 255, 255, 0.13);
    border-radius: 10px;
    color: #fff;
    background: rgba(255, 255, 255, 0.045);
    font: 600 0.75rem/1.4 "JetBrains Mono", monospace;
}

.msa-filter-panel input::placeholder {
    color: rgba(255, 255, 255, 0.33);
}

.msa-filter-panel input:hover,
.msa-filter-panel select:hover {
    border-color: rgba(69, 240, 165, 0.35);
}

.msa-filter-panel select option {
    color: #130828;
    background: #fff;
}

.msa-reset-button {
    min-height: 46px;
    padding: 0.65rem 0.9rem;
    border: 1px solid rgba(69, 240, 165, 0.38);
    border-radius: 10px;
    color: var(--msa-green);
    background: rgba(69, 240, 165, 0.07);
    font: 800 0.72rem/1.3 "JetBrains Mono", monospace;
}

.msa-reset-button:hover {
    color: #06130e;
    background: var(--msa-green);
}

.msa-filter-status {
    grid-column: 1 / -1;
    margin: 0.1rem 0 0;
    color: rgba(255, 255, 255, 0.48);
    font-size: 0.68rem;
}

.msa-table-wrap {
    overflow: auto;
    border: 1px solid var(--msa-border);
    border-top: 0;
    border-radius: 0 0 16px 16px;
    background: rgba(4, 1, 15, 0.9);
    scrollbar-color: rgba(69, 240, 165, 0.45) rgba(255, 255, 255, 0.04);
}

.msa-species-table,
.msa-sample-table,
.msa-qc-table {
    width: 100%;
    min-width: 1080px;
    border-collapse: collapse;
    color: rgba(255, 255, 255, 0.72);
    font-size: 0.69rem;
}

.msa-sample-table {
    min-width: 1120px;
}

.msa-qc-table {
    min-width: 920px;
}

.msa-species-table thead,
.msa-sample-table thead,
.msa-qc-table thead {
    color: rgba(255, 255, 255, 0.52);
    background: rgba(255, 255, 255, 0.035);
    text-transform: uppercase;
    letter-spacing: 0.06em;
}

.msa-species-table th,
.msa-species-table td,
.msa-sample-table th,
.msa-sample-table td,
.msa-qc-table th,
.msa-qc-table td {
    padding: 0.9rem 0.75rem;
    border-bottom: 1px solid rgba(255, 255, 255, 0.075);
    text-align: left;
    vertical-align: middle;
}

.msa-species-table tbody tr,
.msa-sample-table tbody tr,
.msa-qc-table tbody tr {
    transition: background 160ms ease;
}

.msa-species-table tbody tr:hover,
.msa-sample-table tbody tr:hover,
.msa-qc-table tbody tr:hover {
    background: rgba(69, 240, 165, 0.045);
}

.msa-species-table tbody th,
.msa-sample-table tbody th,
.msa-qc-table tbody th {
    color: #fff;
    font-weight: 700;
}

.msa-species-table tbody th em,
.msa-sample-table small,
.msa-qc-table small {
    display: block;
    margin-top: 0.24rem;
    color: rgba(255, 255, 255, 0.44);
    font-family: "Crimson Pro", Georgia, serif;
    font-size: 0.79rem;
    font-weight: 400;
}

.msa-rank {
    display: inline-grid;
    place-items: center;
    min-width: 2rem;
    min-height: 1.7rem;
    padding: 0.2rem;
    border: 1px solid rgba(168, 138, 255, 0.26);
    border-radius: 7px;
    color: var(--msa-violet);
    background: rgba(168, 138, 255, 0.08);
    font-weight: 800;
}

.msa-species-name,
.msa-laca-link,
.msa-sample-table a,
.msa-qc-table a {
    color: var(--msa-green);
    font-weight: 800;
    text-decoration: none;
}

.msa-species-name:hover,
.msa-laca-link:hover,
.msa-sample-table a:hover,
.msa-qc-table a:hover {
    text-decoration: underline;
    text-underline-offset: 0.22rem;
}

.msa-order,
.msa-tissue-label {
    display: inline-flex;
    padding: 0.3rem 0.5rem;
    border: 1px solid rgba(168, 138, 255, 0.22);
    border-radius: 999px;
    color: #c8b8ff;
    background: rgba(168, 138, 255, 0.07);
    font-size: 0.61rem;
    font-weight: 800;
    text-transform: uppercase;
    letter-spacing: 0.05em;
}

.msa-tissue-label {
    color: var(--msa-cyan);
    border-color: rgba(94, 220, 255, 0.26);
    background: rgba(94, 220, 255, 0.07);
}

.msa-tissue-pills {
    display: grid;
    grid-template-columns: repeat(3, minmax(3.6rem, 1fr));
    gap: 0.28rem;
}

.msa-tissue-pills span {
    padding: 0.24rem 0.34rem;
    border: 1px solid rgba(255, 255, 255, 0.07);
    border-radius: 6px;
    color: rgba(255, 255, 255, 0.28);
    background: rgba(255, 255, 255, 0.025);
    font-size: 0.56rem;
    text-align: center;
}

.msa-tissue-pills span.has-samples {
    color: var(--msa-green);
    border-color: rgba(69, 240, 165, 0.21);
    background: rgba(69, 240, 165, 0.065);
}

.msa-count {
    color: #fff;
    font: 800 1rem/1.2 "Orbitron", sans-serif;
}

.msa-route-list,
.msa-record-links {
    display: grid;
    gap: 0.3rem;
}

.msa-route-list a,
.msa-record-links a {
    color: var(--msa-cyan);
    font-size: 0.62rem;
    font-weight: 700;
    text-decoration: none;
}

.msa-route-list a:hover,
.msa-record-links a:hover {
    text-decoration: underline;
    text-underline-offset: 0.2rem;
}

.msa-laca-link + small {
    display: block;
    margin-top: 0.2rem;
    color: rgba(255, 255, 255, 0.4);
    font-size: 0.58rem;
}

.msa-unavailable {
    color: rgba(255, 255, 255, 0.34);
    font-size: 0.62rem;
}

.msa-empty-state {
    margin: 0;
    padding: 2.4rem 1rem;
    color: rgba(255, 255, 255, 0.56);
    text-align: center;
}

.msa-result-grid {
    display: grid;
    grid-template-columns: repeat(3, minmax(0, 1fr));
    gap: 0.9rem;
}

.msa-result-panel {
    min-width: 0;
    padding: 1.15rem;
    border: 1px solid var(--msa-border);
    border-radius: 17px;
    background: var(--msa-surface);
}

.msa-result-panel header {
    min-height: 9rem;
    padding-bottom: 0.9rem;
    border-bottom: 1px solid rgba(255, 255, 255, 0.08);
}

.msa-result-panel header > span,
.msa-method-grid article > span,
.msa-provenance-grid article > span,
.msa-dataset-card > div > span {
    color: var(--msa-green);
    font-size: 0.61rem;
    font-weight: 800;
    letter-spacing: 0.07em;
    text-transform: uppercase;
}

.msa-result-panel h3,
.msa-method-grid h3,
.msa-dataset-card h3,
.msa-route-card h3 {
    margin: 0.5rem 0 0;
    color: #fff;
    font: 800 0.94rem/1.4 "Orbitron", sans-serif;
}

.msa-result-panel header p,
.msa-method-grid p,
.msa-dataset-card p,
.msa-route-card p {
    margin: 0.55rem 0 0;
    color: rgba(255, 255, 255, 0.55);
    font-size: 0.69rem;
    line-height: 1.65;
}

.msa-result-list {
    display: grid;
    gap: 0;
    margin: 0;
    padding: 0;
    list-style: none;
}

.msa-result-list li {
    min-width: 0;
    padding: 0.75rem 0;
    border-bottom: 1px solid rgba(255, 255, 255, 0.065);
}

.msa-result-list li:last-child {
    border-bottom: 0;
}

.msa-result-list strong {
    display: block;
    color: #f8f6ff;
    font-size: 0.68rem;
    overflow-wrap: anywhere;
}

.msa-result-list small {
    display: block;
    margin-top: 0.28rem;
    color: rgba(255, 255, 255, 0.42);
    font-size: 0.57rem;
    line-height: 1.5;
}

.msa-result-bar {
    height: 4px;
}

.msa-result-bar.is-negative i {
    background: linear-gradient(90deg, var(--msa-pink), var(--msa-violet));
    box-shadow: 0 0 12px rgba(255, 120, 200, 0.34);
}

.msa-result-bar.is-cyan i {
    background: linear-gradient(90deg, var(--msa-cyan), var(--msa-violet));
}

.msa-no-results {
    color: rgba(255, 255, 255, 0.45);
    font-size: 0.68rem;
}

.msa-results-boundary {
    margin-top: 0.9rem;
}

.msa-provenance-grid,
.msa-method-grid {
    display: grid;
    grid-template-columns: repeat(3, minmax(0, 1fr));
    gap: 0.85rem;
}

.msa-provenance-grid article,
.msa-method-grid article {
    min-width: 0;
    padding: 1rem;
    border: 1px solid var(--msa-border);
    border-radius: 14px;
    background: var(--msa-surface-soft);
}

.msa-provenance-grid strong {
    display: block;
    margin-top: 0.45rem;
    color: #fff;
    font-size: 0.8rem;
    overflow-wrap: anywhere;
}

.msa-provenance-grid p {
    margin: 0.45rem 0 0;
    color: rgba(255, 255, 255, 0.47);
    font-size: 0.65rem;
    line-height: 1.65;
}

/* Species source page */

.msa-source-identity {
    display: grid;
    grid-template-columns: minmax(150px, 250px) minmax(0, 1fr);
    align-items: center;
    gap: clamp(1.2rem, 3vw, 2.2rem);
}

.msa-source-image {
    aspect-ratio: 4 / 3;
    overflow: hidden;
    border: 1px solid rgba(69, 240, 165, 0.28);
    border-radius: 18px;
    background: rgba(255, 255, 255, 0.92);
}

.msa-source-image img {
    width: 100%;
    height: 100%;
    object-fit: cover;
}

.msa-scientific-name {
    margin: 0.65rem 0 0;
    color: rgba(255, 255, 255, 0.62);
    font: 600 1.02rem/1.4 "Crimson Pro", Georgia, serif;
}

.msa-source-tissue-grid {
    display: grid;
    grid-template-columns: repeat(6, minmax(0, 1fr));
    gap: 0.7rem;
}

.msa-source-tissue-card {
    display: grid;
    gap: 0.65rem;
    min-width: 0;
    padding: 0.85rem;
    border: 1px solid var(--msa-border);
    border-radius: 14px;
    background: var(--msa-surface);
}

.msa-source-tissue-card img {
    width: 100%;
    max-height: 92px;
    object-fit: contain;
    border-radius: 9px;
    background: rgba(255, 255, 255, 0.9);
}

.msa-source-tissue-card button {
    margin-top: 0.55rem;
    padding: 0;
    border: 0;
    color: var(--msa-green);
    background: transparent;
    font: 800 0.62rem/1.3 "JetBrains Mono", monospace;
}

.msa-source-tissue-card button:hover {
    text-decoration: underline;
    text-underline-offset: 0.2rem;
}

.msa-source-tissue-card > div > span {
    display: inline-block;
    margin-top: 0.55rem;
    color: rgba(255, 255, 255, 0.34);
    font-size: 0.61rem;
}

.msa-source-tissue-card.is-absent {
    opacity: 0.46;
}

.msa-route-grid,
.msa-dataset-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(min(100%, 280px), 1fr));
    gap: 0.85rem;
}

.msa-route-card,
.msa-dataset-card {
    display: flex;
    flex-direction: column;
    min-width: 0;
    padding: 1rem;
    border: 1px solid var(--msa-border);
    border-radius: 15px;
    background: var(--msa-surface);
}

.msa-route-card-head,
.msa-dataset-card > div {
    display: flex;
    align-items: center;
    justify-content: space-between;
    gap: 0.7rem;
}

.msa-route-card-head span,
.msa-dataset-card > div strong {
    color: var(--msa-cyan);
    font: 800 0.79rem/1.3 "Orbitron", sans-serif;
}

.msa-route-card-head strong {
    padding: 0.25rem 0.48rem;
    border: 1px solid rgba(69, 240, 165, 0.22);
    border-radius: 999px;
    color: var(--msa-green);
    background: rgba(69, 240, 165, 0.06);
    font-size: 0.55rem;
    text-transform: uppercase;
}

.msa-route-card small {
    display: block;
    margin-top: 0.7rem;
    padding-top: 0.7rem;
    border-top: 1px solid rgba(255, 255, 255, 0.07);
    color: rgba(255, 209, 102, 0.68);
    font-size: 0.59rem;
    line-height: 1.55;
}

.msa-route-card > a,
.msa-dataset-card > a,
.msa-metadata-badge {
    display: inline-block;
    align-self: flex-start;
    margin-top: auto;
    padding-top: 0.85rem;
    color: var(--msa-green);
    font-size: 0.66rem;
    font-weight: 800;
    text-decoration: none;
}

.msa-route-card > a:hover,
.msa-dataset-card > a:hover {
    text-decoration: underline;
    text-underline-offset: 0.22rem;
}

.msa-metadata-badge {
    color: rgba(255, 255, 255, 0.38);
}

.msa-dataset-card dl {
    display: grid;
    gap: 0.42rem;
    margin: 0.85rem 0 0;
}

.msa-dataset-card dl div {
    display: flex;
    justify-content: space-between;
    gap: 0.75rem;
    color: rgba(255, 255, 255, 0.54);
    font-size: 0.62rem;
}

.msa-dataset-card dd {
    margin: 0;
    color: #fff;
    text-align: right;
}

.msa-sample-filter-panel {
    grid-template-columns: minmax(250px, 1.35fr) minmax(180px, 0.65fr) minmax(180px, 0.65fr) auto;
}

.msa-sample-table td > strong,
.msa-sample-table td > span,
.msa-qc-table td > strong {
    display: block;
}

.msa-laca-card {
    display: flex;
    align-items: center;
    justify-content: space-between;
    gap: 1rem;
    padding: 1.2rem;
    border: 1px solid rgba(69, 240, 165, 0.3);
    border-radius: 16px;
    background:
        radial-gradient(circle at 95% 50%, rgba(69, 240, 165, 0.12), transparent 34%),
        var(--msa-surface);
}

.msa-laca-card > div {
    min-width: 0;
}

.msa-laca-card span,
.msa-laca-card > div:last-child > strong {
    color: var(--msa-green);
    font-size: 0.62rem;
    font-weight: 800;
    text-transform: uppercase;
    letter-spacing: 0.06em;
}

.msa-laca-card h3 {
    margin: 0.4rem 0 0;
    color: #fff;
    font: 800 1.05rem/1.35 "Orbitron", sans-serif;
}

.msa-laca-card p {
    margin: 0.35rem 0 0;
    color: rgba(255, 255, 255, 0.56);
    font-size: 0.72rem;
}

.msa-laca-card > div:last-child {
    display: grid;
    justify-items: end;
    gap: 0.7rem;
}

.msa-footer-actions {
    margin-top: 2rem;
}

/* Native expression page */

.msa-native-metrics {
    grid-template-columns: repeat(4, minmax(0, 1fr));
}

.msa-pca-layout {
    display: grid;
    grid-template-columns: minmax(0, 1.45fr) minmax(260px, 0.55fr);
    gap: 0.9rem;
}

.msa-pca-figure,
.msa-pca-sidebar {
    min-width: 0;
    margin: 0;
    padding: 1rem;
    border: 1px solid var(--msa-border);
    border-radius: 17px;
    background: var(--msa-surface);
}

.msa-pca-figure svg {
    display: block;
    width: 100%;
    height: auto;
    min-height: 320px;
}

.msa-pca-grid line {
    stroke: rgba(255, 255, 255, 0.1);
    stroke-width: 1;
}

.msa-pca-axis-labels {
    fill: rgba(255, 255, 255, 0.54);
    font: 700 12px/1 "JetBrains Mono", monospace;
}

.msa-pca-points circle {
    stroke: rgba(6, 2, 16, 0.88);
    stroke-width: 2;
    transition: r 160ms ease, filter 160ms ease, stroke 160ms ease;
}

.msa-pca-points circle:hover,
.msa-pca-points circle:focus {
    r: 10;
    stroke: #fff;
    filter: drop-shadow(0 0 8px currentColor);
}

.msa-tone-0 { fill: #5edcff; background: #5edcff; }
.msa-tone-1 { fill: #a88aff; background: #a88aff; }
.msa-tone-2 { fill: #ff78c8; background: #ff78c8; }
.msa-tone-3 { fill: #45f0a5; background: #45f0a5; }
.msa-tone-4 { fill: #ffd166; background: #ffd166; }
.msa-tone-5 { fill: #ff8f70; background: #ff8f70; }
.msa-tone-6 { fill: #d7d2e8; background: #d7d2e8; }

.msa-pca-figure figcaption {
    margin-top: 0.5rem;
    color: rgba(255, 255, 255, 0.44);
    font-size: 0.62rem;
    line-height: 1.6;
}

.msa-pca-sidebar h3 {
    margin: 0;
    color: #fff;
    font: 800 0.88rem/1.35 "Orbitron", sans-serif;
}

.msa-pca-legend {
    display: grid;
    gap: 0.5rem;
    margin: 0.8rem 0 0;
    padding: 0;
    list-style: none;
}

.msa-pca-legend li {
    display: grid;
    grid-template-columns: auto 1fr auto;
    align-items: center;
    gap: 0.55rem;
    color: rgba(255, 255, 255, 0.62);
    font-size: 0.68rem;
}

.msa-pca-legend i {
    width: 0.72rem;
    height: 0.72rem;
    border-radius: 50%;
}

.msa-pca-legend strong {
    color: #fff;
}

.msa-pca-method {
    display: grid;
    gap: 0.7rem;
    margin: 1rem 0 0;
    padding-top: 1rem;
    border-top: 1px solid rgba(255, 255, 255, 0.08);
}

.msa-pca-method dt {
    color: var(--msa-green);
    font-size: 0.57rem;
    font-weight: 800;
    text-transform: uppercase;
    letter-spacing: 0.05em;
}

.msa-pca-method dd {
    margin: 0.25rem 0 0;
    color: rgba(255, 255, 255, 0.55);
    font-size: 0.63rem;
    line-height: 1.55;
}

.msa-qc-section .msa-table-wrap {
    border-top: 1px solid var(--msa-border);
    border-radius: 16px;
}

.msa-feature-chart {
    display: grid;
    grid-template-columns: repeat(2, minmax(0, 1fr));
    gap: 0.7rem;
    margin: 0;
    padding: 0;
    list-style: none;
}

.msa-feature-chart > li {
    display: grid;
    grid-template-columns: auto minmax(120px, 0.8fr) minmax(210px, 1fr);
    align-items: center;
    gap: 0.75rem;
    min-width: 0;
    padding: 0.85rem;
    border: 1px solid var(--msa-border);
    border-radius: 13px;
    background: var(--msa-surface);
}

.msa-feature-chart > li > div {
    min-width: 0;
}

.msa-feature-chart > li > div strong {
    display: block;
    color: #fff;
    font-size: 0.71rem;
    overflow-wrap: anywhere;
}

.msa-feature-chart dl {
    display: grid;
    grid-template-columns: repeat(3, minmax(0, 1fr));
    gap: 0.55rem;
    margin: 0;
}

.msa-feature-chart dt {
    color: rgba(255, 255, 255, 0.38);
    font-size: 0.52rem;
    line-height: 1.35;
    text-transform: uppercase;
}

.msa-feature-chart dd {
    margin: 0.2rem 0 0;
    color: var(--msa-cyan);
    font-size: 0.61rem;
    overflow-wrap: anywhere;
}

.msa-excluded-section > ul {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(min(100%, 260px), 1fr));
    gap: 0.7rem;
    margin: 0;
    padding: 0;
    list-style: none;
}

.msa-excluded-section li {
    padding: 0.85rem;
    border: 1px solid rgba(255, 209, 102, 0.22);
    border-radius: 12px;
    background: rgba(255, 209, 102, 0.055);
}

.msa-excluded-section li strong,
.msa-excluded-section li span,
.msa-excluded-section li small {
    display: block;
}

.msa-excluded-section li strong {
    color: #fff;
    font-size: 0.7rem;
}

.msa-excluded-section li span {
    margin-top: 0.3rem;
    color: var(--msa-amber);
    font-size: 0.63rem;
}

.msa-excluded-section li small {
    margin-top: 0.3rem;
    color: rgba(255, 255, 255, 0.46);
    font-size: 0.59rem;
    line-height: 1.5;
}

.msa-method-grid {
    grid-template-columns: repeat(4, minmax(0, 1fr));
}

.msa-method-grid code {
    display: block;
    margin-top: 0.35rem;
    color: var(--msa-cyan);
    font-size: 0.56rem;
    overflow-wrap: anywhere;
}

.msa-error-hero {
    min-height: 380px;
    display: flex;
    flex-direction: column;
    justify-content: center;
}

@media (max-width: 1180px) {
    .msa-tissue-grid,
    .msa-result-grid {
        grid-template-columns: repeat(2, minmax(0, 1fr));
    }

    .msa-source-tissue-grid {
        grid-template-columns: repeat(3, minmax(0, 1fr));
    }

    .msa-filter-panel,
    .msa-sample-filter-panel {
        grid-template-columns: minmax(240px, 1fr) minmax(180px, 0.65fr) minmax(180px, 0.65fr);
    }

    .msa-reset-button {
        grid-column: 1 / -1;
        justify-self: start;
    }

    .msa-feature-chart {
        grid-template-columns: 1fr;
    }

    .msa-method-grid {
        grid-template-columns: repeat(2, minmax(0, 1fr));
    }
}

@media (max-width: 900px) {
    .msa-hero,
    .msa-source-hero,
    .msa-native-hero,
    .msa-pca-layout {
        grid-template-columns: 1fr;
    }

    .msa-hero-ledger,
    .msa-source-ledger,
    .msa-native-ledger {
        grid-template-columns: repeat(2, minmax(0, 1fr));
    }

    .msa-source-identity {
        grid-template-columns: minmax(130px, 190px) minmax(0, 1fr);
    }

    .msa-provenance-grid,
    .msa-native-metrics {
        grid-template-columns: repeat(2, minmax(0, 1fr));
    }

    .msa-pca-figure svg {
        min-width: 600px;
    }

    .msa-pca-figure {
        overflow-x: auto;
    }
}

@media (max-width: 700px) {
    .msa-page {
        width: min(100% - 1rem, 1500px);
    }

    .msa-hero,
    .msa-source-hero,
    .msa-native-hero {
        padding: 1.25rem;
        border-radius: 18px;
    }

    .msa-hero h1,
    .msa-source-hero h1,
    .msa-native-hero h1 {
        font-size: clamp(1.8rem, 11vw, 3rem);
        overflow-wrap: anywhere;
    }

    .msa-hero-ledger,
    .msa-source-ledger,
    .msa-native-ledger,
    .msa-tissue-grid,
    .msa-result-grid,
    .msa-provenance-grid,
    .msa-method-grid,
    .msa-native-metrics {
        grid-template-columns: 1fr;
    }

    .msa-source-identity {
        grid-template-columns: 1fr;
    }

    .msa-source-image {
        max-width: 260px;
    }

    .msa-source-tissue-grid {
        grid-template-columns: repeat(2, minmax(0, 1fr));
    }

    .msa-filter-panel,
    .msa-sample-filter-panel {
        grid-template-columns: 1fr;
        border-radius: 14px;
    }

    .msa-reset-button {
        grid-column: auto;
        width: 100%;
    }

    .msa-tissue-card {
        grid-template-columns: 84px minmax(0, 1fr);
    }

    .msa-result-panel header {
        min-height: auto;
    }

    .msa-laca-card {
        display: grid;
    }

    .msa-laca-card > div:last-child {
        justify-items: start;
    }

    .msa-feature-chart > li {
        grid-template-columns: auto minmax(0, 1fr);
    }

    .msa-feature-chart dl {
        grid-column: 1 / -1;
        padding-left: 2.75rem;
    }

    .msa-table-wrap {
        overflow: visible;
        border: 0;
        background: transparent;
    }

    .msa-species-table,
    .msa-sample-table,
    .msa-qc-table {
        min-width: 0;
    }

    .msa-species-table thead,
    .msa-sample-table thead,
    .msa-qc-table thead {
        position: absolute;
        width: 1px;
        height: 1px;
        padding: 0;
        margin: -1px;
        overflow: hidden;
        clip: rect(0, 0, 0, 0);
        white-space: nowrap;
        border: 0;
    }

    .msa-species-table tbody,
    .msa-sample-table tbody,
    .msa-qc-table tbody {
        display: grid;
        gap: 0.75rem;
    }

    .msa-species-table tbody tr,
    .msa-sample-table tbody tr,
    .msa-qc-table tbody tr {
        display: grid;
        padding: 0.4rem 0.8rem;
        border: 1px solid var(--msa-border);
        border-radius: 13px;
        background: var(--msa-surface);
    }

    .msa-species-table th,
    .msa-species-table td,
    .msa-sample-table th,
    .msa-sample-table td,
    .msa-qc-table th,
    .msa-qc-table td {
        display: grid;
        grid-template-columns: minmax(6.8rem, 0.45fr) minmax(0, 1fr);
        gap: 0.7rem;
        align-items: start;
        padding: 0.65rem 0;
    }

    .msa-species-table [data-label]::before,
    .msa-sample-table [data-label]::before,
    .msa-qc-table [data-label]::before {
        content: attr(data-label);
        color: rgba(255, 255, 255, 0.37);
        font-size: 0.56rem;
        font-weight: 800;
        text-transform: uppercase;
        letter-spacing: 0.05em;
    }

    .msa-tissue-pills {
        grid-template-columns: repeat(3, minmax(0, 1fr));
    }
}

@media (max-width: 430px) {
    .msa-source-tissue-grid {
        grid-template-columns: 1fr;
    }

    .msa-feature-chart dl {
        grid-template-columns: 1fr;
    }

    .msa-native-ledger,
    .msa-hero-ledger,
    .msa-source-ledger {
        grid-template-columns: 1fr;
    }
}

@media (prefers-reduced-motion: reduce) {
    .msa-page *,
    .msa-page *::before,
    .msa-page *::after {
        scroll-behavior: auto !important;
        transition-duration: 0.01ms !important;
        animation-duration: 0.01ms !important;
        animation-iteration-count: 1 !important;
    }
}