{
  "release_id": "r20260813-v1",
  "generated_at": "2026-08-13T04:27:47.369496+00:00",
  "status": "ready",
  "schema_version": "1.0",
  "signature_set_id": "LACA-HOA12-TRANSCRIPTOME-v1",
  "source": {
    "file": "SP121.h5ad",
    "n_cells": 1246365,
    "n_genes": 19739
  },
  "signatures": [
    {
      "id": "genomic_instability",
      "label": "Genomic instability",
      "gene_count": 18,
      "mapped_count": 18,
      "missing_count": 0,
      "coverage": 1.0,
      "vector_bytes": 4211146,
      "vector_sha256": "737e87ab5eb398d69c17e7f6bc912a58cced1c26ca0c82eaa0394a2743619503"
    },
    {
      "id": "telomere_attrition",
      "label": "Telomere attrition",
      "gene_count": 14,
      "mapped_count": 13,
      "missing_count": 1,
      "coverage": 0.9285714285714286,
      "vector_bytes": 3153305,
      "vector_sha256": "eb60470f83148796465d8a2090133e702139f1759c33684cdb59b0bedd38d5ac"
    },
    {
      "id": "epigenetic_alterations",
      "label": "Epigenetic alterations",
      "gene_count": 18,
      "mapped_count": 18,
      "missing_count": 0,
      "coverage": 1.0,
      "vector_bytes": 4207394,
      "vector_sha256": "314b94833265ae07465866fc8e1eb5d9a650af5baebe994c35391eccc137dbb8"
    },
    {
      "id": "loss_of_proteostasis",
      "label": "Loss of proteostasis",
      "gene_count": 20,
      "mapped_count": 20,
      "missing_count": 0,
      "coverage": 1.0,
      "vector_bytes": 4293857,
      "vector_sha256": "4aa737585bf021980c776578128ce005d679674b3d60c6a342312123063bd1d4"
    },
    {
      "id": "disabled_macroautophagy",
      "label": "Disabled macroautophagy",
      "gene_count": 19,
      "mapped_count": 19,
      "missing_count": 0,
      "coverage": 1.0,
      "vector_bytes": 4326599,
      "vector_sha256": "29aac6115daa0aa10e484a3fdb8923e0b7fa6053d785e765304ac77ba078f2d2"
    },
    {
      "id": "deregulated_nutrient_sensing",
      "label": "Deregulated nutrient sensing",
      "gene_count": 18,
      "mapped_count": 18,
      "missing_count": 0,
      "coverage": 1.0,
      "vector_bytes": 4250692,
      "vector_sha256": "f1e67acf1f63012c5bb58a32f7624bfd6c4c8d5f963aded27b78d372069ba739"
    },
    {
      "id": "mitochondrial_dysfunction",
      "label": "Mitochondrial dysfunction",
      "gene_count": 19,
      "mapped_count": 18,
      "missing_count": 1,
      "coverage": 0.9473684210526315,
      "vector_bytes": 4309664,
      "vector_sha256": "c68cc40150f9c40c630bffb96c53fafc5ea3aa09febf213f6a7259e892f4d2b5"
    },
    {
      "id": "cellular_senescence",
      "label": "Cellular senescence",
      "gene_count": 18,
      "mapped_count": 18,
      "missing_count": 0,
      "coverage": 1.0,
      "vector_bytes": 4237302,
      "vector_sha256": "c967d06d6edd995e39243454ed725b6db9d75655337f5b786dc1a6977695eb2b"
    },
    {
      "id": "stem_cell_exhaustion",
      "label": "Stem cell exhaustion",
      "gene_count": 16,
      "mapped_count": 16,
      "missing_count": 0,
      "coverage": 1.0,
      "vector_bytes": 3498584,
      "vector_sha256": "8a3846b6f7f21b2a9631716d272e0c11496d3921601944e0984a30c2e9fb47dd"
    },
    {
      "id": "altered_intercellular_communication",
      "label": "Altered intercellular communication",
      "gene_count": 19,
      "mapped_count": 19,
      "missing_count": 0,
      "coverage": 1.0,
      "vector_bytes": 4106118,
      "vector_sha256": "3098f7705b0b18ccb0814930583937a141af1e632f1bd7f3ca4cf6992455f61f"
    },
    {
      "id": "chronic_inflammation",
      "label": "Chronic inflammation",
      "gene_count": 19,
      "mapped_count": 19,
      "missing_count": 0,
      "coverage": 1.0,
      "vector_bytes": 4077911,
      "vector_sha256": "1150fc6bb305ee73ade959334f68b13f875934cd16cf2afac9bab2b539bd8d5b"
    },
    {
      "id": "dysbiosis",
      "label": "Dysbiosis",
      "gene_count": 18,
      "mapped_count": 18,
      "missing_count": 0,
      "coverage": 1.0,
      "vector_bytes": 3315803,
      "vector_sha256": "fa4b0b0fa257f34648ab3d338dd8e4b92438a452e95da120b4f041840b8896ab"
    }
  ],
  "files": {
    "hallmarks.json": {
      "bytes": 6189570,
      "sha256": "bc99f3169bcc01b94cd4c87e54a85d3a9c78c18e657eb377f5a04ee6e0057087"
    },
    "signatures.json": {
      "bytes": 9064,
      "sha256": "7209a82fcd0e9a5d9cc0fe12550350ae2e3a918e96b5f423ffaf74b169349fef"
    },
    "summary.csv": {
      "bytes": 333459,
      "sha256": "071a19e8658c3276b7a152ed8380a5ad914a0de8e03e78d7062b2e52db6c3174"
    },
    "vectors/altered_intercellular_communication.bin.gz": {
      "bytes": 4106118,
      "sha256": "3098f7705b0b18ccb0814930583937a141af1e632f1bd7f3ca4cf6992455f61f"
    },
    "vectors/cellular_senescence.bin.gz": {
      "bytes": 4237302,
      "sha256": "c967d06d6edd995e39243454ed725b6db9d75655337f5b786dc1a6977695eb2b"
    },
    "vectors/chronic_inflammation.bin.gz": {
      "bytes": 4077911,
      "sha256": "1150fc6bb305ee73ade959334f68b13f875934cd16cf2afac9bab2b539bd8d5b"
    },
    "vectors/deregulated_nutrient_sensing.bin.gz": {
      "bytes": 4250692,
      "sha256": "f1e67acf1f63012c5bb58a32f7624bfd6c4c8d5f963aded27b78d372069ba739"
    },
    "vectors/disabled_macroautophagy.bin.gz": {
      "bytes": 4326599,
      "sha256": "29aac6115daa0aa10e484a3fdb8923e0b7fa6053d785e765304ac77ba078f2d2"
    },
    "vectors/dysbiosis.bin.gz": {
      "bytes": 3315803,
      "sha256": "fa4b0b0fa257f34648ab3d338dd8e4b92438a452e95da120b4f041840b8896ab"
    },
    "vectors/epigenetic_alterations.bin.gz": {
      "bytes": 4207394,
      "sha256": "314b94833265ae07465866fc8e1eb5d9a650af5baebe994c35391eccc137dbb8"
    },
    "vectors/genomic_instability.bin.gz": {
      "bytes": 4211146,
      "sha256": "737e87ab5eb398d69c17e7f6bc912a58cced1c26ca0c82eaa0394a2743619503"
    },
    "vectors/loss_of_proteostasis.bin.gz": {
      "bytes": 4293857,
      "sha256": "4aa737585bf021980c776578128ce005d679674b3d60c6a342312123063bd1d4"
    },
    "vectors/mitochondrial_dysfunction.bin.gz": {
      "bytes": 4309664,
      "sha256": "c68cc40150f9c40c630bffb96c53fafc5ea3aa09febf213f6a7259e892f4d2b5"
    },
    "vectors/stem_cell_exhaustion.bin.gz": {
      "bytes": 3498584,
      "sha256": "8a3846b6f7f21b2a9631716d272e0c11496d3921601944e0984a30c2e9fb47dd"
    },
    "vectors/telomere_attrition.bin.gz": {
      "bytes": 3153305,
      "sha256": "eb60470f83148796465d8a2090133e702139f1759c33684cdb59b0bedd38d5ac"
    }
  }
}