TFs Analyzed
55
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP1804
Published legacy analysis modules for the selected page.
๐ Species Level
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=2,339,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
232
Thresholded Pearson associations
Top TF Association Counts
AR
9 associations
BCL6
6 associations
ESR1
5 associations
IRF4
9 associations
PPARG
17 associations
PRDM1
8 associations
RUNX1
18 associations
RUNX2
13 associations
RXRA
95 associations
SOX2
22 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
800
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
8
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| SLC1A3 | 22.6946 | 4.8904 | 0 | 0 | 0.9533 | 0.284 | Astrocytes |
| PHKG1 | 14.6142 | 4.5962 | 0 | 0 | 0.5833 | 0.076 | Astrocytes |
| FABP7 | 15.3282 | 3.9962 | 0 | 0 | 0.6567 | 0.1319 | Astrocytes |
| SLC6A11 | 16.1312 | 3.8391 | 0 | 0 | 0.7033 | 0.2276 | Astrocytes |
| MSI2 | 20.3601 | 3.7662 | 0 | 0 | 0.9333 | 0.4154 | Astrocytes |
| EGF | 15.7025 | 3.7655 | 0 | 0 | 0.7 | 0.154 | Astrocytes |
| VIT | 7.8929 | 3.6799 | 0 | 0 | 0.32 | 0.0383 | Astrocytes |
| MEGF10 | 14.6749 | 3.5345 | 0 | 0 | 0.6667 | 0.1437 | Astrocytes |
| PAX3 | 8.4801 | 3.4726 | 0 | 0 | 0.3533 | 0.0525 | Astrocytes |
| ANOS1 | 11.8205 | 3.3892 | 0 | 0 | 0.5167 | 0.101 | Astrocytes |
| FLACC1 | 8.6184 | 4.0661 | 0 | 0 | 0.34 | 0.0363 | Ependymal cells |
| DNAH9 | 13.646 | 4.0381 | 0 | 0 | 0.5633 | 0.101 | Ependymal cells |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
12
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
8
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
8
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
13
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
8
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Fibroblasts | Kinase inhibitor | CML / GIST | 1 | 5 | 0.3004 | 10.6667 | 0 | ABL1 |
| Imatinib | Microglia | Kinase inhibitor | CML / GIST | 1 | 5 | 0.2967 | 10.6667 | 0 | ABL1 |
| Imatinib | Astrocytes | Kinase inhibitor | CML / GIST | 1 | 5 | 0.1395 | 5.6667 | 0 | ABL1 |
| Imatinib | Ependymal cells | Kinase inhibitor | CML / GIST | 1 | 5 | 0.1745 | 6.6667 | 0 | ABL1 |
| Imatinib | Oligodendrocytes | Kinase inhibitor | CML / GIST | 1 | 5 | 0.2971 | 11.6667 | 0 | ABL1 |
| Imatinib | Excitatory neurons | Kinase inhibitor | CML / GIST | 1 | 5 | 0.2851 | 14.3333 | 0 | ABL1 |
| Imatinib | Inhibitory neurons | Kinase inhibitor | CML / GIST | 1 | 5 | 0.2148 | 11.3333 | 0 | ABL1 |
| Imatinib | Oligodendrocyte progenitor cells | Kinase inhibitor | CML / GIST | 1 | 5 | 0.2954 | 13.3891 | 0 | ABL1 |
| Trastuzumab | Fibroblasts | mAb | Breast cancer | 1 | 1 | 0.0258 | 1 | 0 | ERBB2 |
| Trastuzumab | Microglia | mAb | Breast cancer | 1 | 1 | 0 | 0 | 0 | ERBB2 |
| Trastuzumab | Astrocytes | mAb | Breast cancer | 1 | 1 | 0.0459 | 2 | 0 | ERBB2 |
| Trastuzumab | Ependymal cells | mAb | Breast cancer | 1 | 1 | 0.0149 | 0.6667 | 0 | ERBB2 |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP1804
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP1804_summary.json | Summary (JSON) | ๐ฅ Download |