Longevity & Aging Biomarker Atlas
A curated panel of well-established biomarkers of aging and longevity — from epigenetic clocks and longevity genes to cellular senescence, immune/inflammatory and metabolic markers. Each card carries a live PubMed evidence count (NCBI E-utilities) and a direct link to the underlying literature. Use the search workspace to query PubMed for any biomarker of interest.
Evidence search
Searches open a live, relevance-ranked view of the top 25 matching records.
Live data via NCBI E-utilities · counts cached for 24 h · rate-limited to 2.5 requests/s
Curated evidence panel
Aging / Epigenetic Clocks
Multi-tissue DNAmAge clock (353 CpGs), the reference pan-tissue biological-age estimator.
Aging / Epigenetic Clocks
Blood-based DNAm age clock (71 CpGs) trained on whole blood.
Aging / Epigenetic Clocks
Composite DNAm surrogate of phenotypic/mortality risk; correlates with morbidity & mortality.
Aging / Epigenetic Clocks
DNAm clock designed to predict life expectancy / time-to-death; strongest mortality predictor among clocks.
Aging / Epigenetic Clocks
Rates-of-aging pace-of-aging biomarker derived from longitudinal change, not a static age.
Longevity Genes
Longevity-associated transcription factor; FOXO3 variants among the most replicated human longevity loci.
Longevity Genes
Anti-aging protein; circulating soluble α-Klotho associated with cognitive & kidney health, lifespan extension.
Longevity Genes
NAD+-dependent deacetylase; mediates caloric-restriction lifespan effects, regulates metabolism & stress resistance.
Longevity Genes
Telomere attrition is a classic hallmark of aging; telomere length a widely used biomarker.
Longevity Genes
Nutrient-sensing kinase; rapamycin & reduced mTOR signaling extend lifespan across model organisms.
Longevity Genes
Cellular energy sensor; activation mimics caloric restriction and is linked to longevity pathways.
Longevity Genes
Central redox cofactor that declines with age; NAD+ precursors (NMN/NR) studied for rejuvenation.
Longevity Genes
Reduced IGF-1/insulin signaling (e.g., Laron dwarfism, dwarf mice) associated with exceptional longevity.
Cellular Senescence / SASP
Cell-cycle inhibitor; p16 accumulates with age in tissues & blood (T cells), a key senescence biomarker.
Cellular Senescence / SASP
Stress-responsive SASP cytokine; rising with age and a strong predictor of all-cause mortality & frailty.
Cellular Senescence / SASP
Pro-inflammatory SASP cytokine; chronic low-grade elevation core to inflammaging.
Cellular Senescence / SASP
Gold-standard histochemical marker of cellular senescence in vitro and in tissues.
Cellular Senescence / SASP
Nuclear-envelope marker; Lamin B1 loss is an early and robust senescence marker.
Immune & Inflammatory
Circulating acute-phase protein; low-grade elevation predicts cardiovascular death & biological aging.
Immune & Inflammatory
Naive T-cell loss, thymic involution & CD4/CD8 ratio shifts index immunological aging.
Immune & Inflammatory
Chronic CMV drives memory T-cell clonal expansion, a hallmark of immunosenescence.
Metabolic & Clinical
Long-term glycemia; glucose metabolism distortion is a core pillar of metabolic aging.
Metabolic & Clinical
Renal clearance declines with age; cystatin C a mortality-sensitive biomarker.
Metabolic & Clinical
Amino-acid metabolite elevated with age; associated with vascular & cognitive aging.
Metabolic & Clinical
Hormone-vitamin; deficiency associated with frailty, falls and mortality in aging.