Longevity · Migrated from SPEED

Somatic Mutation–Lifespan Relationship

Explore how annual somatic mutation rates in clonally derived intestinal crypts scale inversely with lifespan across mammals, then inspect the underlying migrated SNP and INDEL catalogue.

16 species studied56 individuals208 crypts15 species in regressionClonal crypt WGS

Association overview

Lower annual mutation rates accompany longer lifespans

The study-level relationship is the primary result. Each point below is a species summary; it is not a SNP-level association and does not establish that an individual variant causes longevity.

Regression coverage15 speciesHarbour porpoise excluded because sampled-individual age was unknown

Variance explained85%Published allometric model, fraction of variance explained

Allometric-model P1 × 10⁻⁶Published P value from the allometric model; this is a test of association, not a measure of association strength

Log–log slope-0.8695% CI -1.08 to -0.65

Lifespan versus annual SBS rateBoth axes are logarithmic. Select a point to update the species summary.

The line and confidence band are an exploratory OLS visualization calculated from the displayed species summaries. The evidence cards report the paper's allometric-model results.

Species catalog

Choose a mammalian WGS dataset

Choose one of 16 clonal intestinal-crypt WGS catalogues. Historical SPEED labels and RDS identifiers are retained as provenance; these are neither single-cell transcriptomic genotypes nor germline GWAS datasets.

Variant browser

Human records

Filters are applied on the server to the complete migrated text files. A maximum of 100 rows is returned per request; every source column remains available in each row's expandable details.

No variant-level longevity association tested

Variant type

Chromosome

Position from

Position to

Gene contains (SNP)

Rows

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Reference & data provenance

Primary study and source datasets

The displayed catalogue is linked to a comparative mammalian somatic-mutation study of 208 intestinal crypts from 56 individuals across 16 species.

Primary reference. Cagan, A., Baez-Ortega, A., Brzozowska, N. et al. Somatic mutation rates scale with lifespan across mammals. Nature 604, 517–524 (2022). — DOI: 10.1038/s41586-022-04618-z · PMID: 35418684

Displayed catalogue and processed data. LACA serves migrated, annotated SPEED SNP/INDEL tables associated with the study's 16-species processed mutation catalogue. The official processed mutation calls and analysis data are openly available from Zenodo DOI 10.5281/zenodo.5554777.

Raw sequence data. Study sequence files are archived under controlled access at EGA EGAD00001008032; reused human sequence data are archived separately at EGA EGAD00001004192. Access approval is required.

Analysis code. The authors' analysis code is available from Zenodo DOI 10.5281/zenodo.5554801 and CrossSpecies2021 on GitHub.