Longevity interventions
CR, rapamycin, GHR-KO, KU0063794, and metformin from Tyshkovskiy et al., Cell 2023. SP121 maps show where annotated targets are expressed, not whether a compound works.
In this paper, long-lived-species signatures often move with aging (reinforcing / divergent), while CR, rapamycin, GHR-KO, and KU0063794 move against aging expression (counteracting).
Calorie Restriction (CR)
In the paper’s 92-dataset aging meta-analysis, CR opposes age-related expression changes rather than amplifying them (PMID 37269831).
Effect on aging: reverses aging expression patterns
Rapamycin / mTOR inhibition
mTORC1 inhibition extends lifespan in model organisms and reduces nutrient-sensing programs that rise with age (PMID 37142830).
Effect on aging: reverses aging expression patterns
Growth Hormone Receptor Knockout (GHR-KO)
GHR-null mice live longer. The GH/IGF-1/insulin axis is the same downregulation tracked on the Relationship page (PMID 37269831).
Effect on aging: low growth axis opposing age-driven rise
KU0063794
Nominated in Tyshkovskiy et al. 2023 using longevity/aging biomarkers. Dual mTORC1/2 inhibition extended remaining lifespan in old mice (PMID 37269831).
Effect on aging: extends remaining lifespan & healthspan in aged mice
Metformin (context)
AMPK-linked energy-metabolism candidate, included for context (PMID 32333835, Kulkarni et al., Cell Metab. 2020).
Effect on aging: AMPK activation opposing age-driven metabolic decline
Atlas Target Availability
Select one of the 18 curated drugs to inspect where its annotated molecular targets are expressed across
107 SP121 human atlas cell types. Each cell-type image links to the matching
content.php atlas view.
▸ Intervention filter table
| Intervention | Route | Pathway | Effect on aging | Evidence | PMID |
|---|---|---|---|---|---|
| Calorie Restriction (CR) | Dietary | Nutrient sensing / energy metabolism | Counteracting | Established | PMID 37269831 ↗ |
| Rapamycin / mTOR inhibition | Pharmacological | MTOR / nutrient sensing | Counteracting | Established | PMID 37142830 ↗ |
| Growth Hormone Receptor Knockout (GHR-KO) | Genetic | GH/IGF1 axis | Counteracting | Established | PMID 37269831 ↗ |
| KU0063794 | Pharmacological (discovered via longevity biomarkers) | mTOR / PI3K-Akt | Counteracting | Candidate | PMID 37269831 ↗ |
| Metformin (context) | Pharmacological | AMPK / energy metabolism | Counteracting | Candidate | PMID 32333835 ↗ |
Curated from Tyshkovskiy et al., Cell 2023, Distinct longevity mechanisms across and within species and their association with aging (PMID 37269831). KU0063794 was identified using the paper's longevity/aging biomarkers and validated to extend remaining lifespan and healthspan in aged mice; the other interventions are established mammalian lifespan-extenders referenced in the same work. All PubMed links point to verified key references.