⚙ How is this computed? Methods: Cross-Species Comparison

Gene Longevity Correlation

Query the Spearman rank correlation between a gene's expression level and maximum lifespan across all LACA species in which the queried gene has a confidently mapped ortholog and detectable expression; the exact species set is reported with each result.

Accepts any standard HGNC gene symbol

Popular: TP53 SIRT1 FOXO3 TERT MTOR KLOTHO IGF1R SOD2 LMNA BECN1 PARP1 WRN

Analysis Result

TP53
Spearman ฯ
-0.1483
rank correlation coefficient
P-value
0.1494
two-tailed significance
Species
96
data points
Significance
n.s.
not significant
PGLS ฮฒ
+0.073
phylogenetic generalized least squares
PGLS P-value
0.7795
TimeTree5 phylogeny + logโ‚โ‚€ body mass covariate
Pagel's ฮป
0.90
estimated phylogenetic signal
PGLS FDR
1.000
genome-wide corrected
The PGLS statistics above control for phylogenetic relatedness (TimeTree5 time-calibrated phylogeny, Pagel's ฮป estimated by maximum likelihood) and adult body mass. All correlations in LACA are descriptive, species-level associations intended for hypothesis generation; they are not evidence of convergent evolution, natural selection, or causation.
Interpretation: The expression of TP53 shows a negligible negative correlation with maximum lifespan (ฯ = -0.1483). However, this association is not statistically significant (P = 0.1494). Based on cross-species comparison of 96 species.

Expression vs. Maximum Lifespan

Rankโ€“Rank Plot (Spearman Basis)

Detailed Data (96 species)

# Species Common Name Expression Expr. Rank Max Lifespan (yr) Lifespan Rank
1 Acanthopagrus latus Yellowfin seabream 0.0582 51 15.0 38.5
2 Amphiprion ocellaris Ocellaris clownfish 0.1006 73 12.0 31
3 Amphiprion percula Orange clownfish 0.0764 60 30.0 72
4 Anabas testudineus Climbing perch 0.0679 54.5 8.0 16
5 Astyanax mexicanus Mexican tetra 0.0679 54.5 5.0 9
6 Betta splendens Siamese fighting fish 0.2983 94 5.0 9
7 Carassius auratus Goldfish 0.0392 39 41.0 90
8 Channa argus Northern snakehead 0.0801 62 10.0 23
9 Chelmon rostratus Copperband butterflyfish 0.1966 91 10.0 23
10 Chiloscyllium plagiosum Whitespotted bamboo shark 0.0112 8 25.0 65.5
11 Ctenopharyngodon idella Grass carp 0.0427 41 21.0 59.5
12 Cyprinus carpio Common carp 0.0558 49 38.0 84
13 Danio rerio Zebrafish 0.0896 68 5.5 13
14 Echeneis naucrates Live sharksucker 0.1306 78 5.0 9
15 Epinephelus fuscoguttatus Brown-marbled grouper 0.0381 37 40.0 88
16 Epinephelus lanceolatus Giant grouper 0.0545 48 37.0 80.5
17 Erpetoichthys calabaricus Reedfish 0.1114 74 18.0 45.5
18 Esox lucius Northern pike 0.6238 96 30.0 72
19 Gambusia affinis Western mosquitofish 0.0425 40 3.0 1
20 Lates calcarifer Barramundi 0.0698 56 20.0 55.5
21 Mastacembelus armatus Zig-zag eel 0.0273 24.5 15.0 38.5
22 Megalobrama amblycephala Blunt snout bream 0.0383 38 15.0 38.5
23 Melanotaenia boesemani Boeseman's rainbowfish 0.0787 61 8.0 16
24 Micropterus salmoides Largemouth bass 0.0707 57 16.0 42
25 Misgurnus anguillicaudatus Pond loach 0.0838 64 10.0 23
26 Monopterus albus Asian swamp eel 0.1485 82 10.0 23
27 Oncorhynchus mykiss Rainbow trout 0.0572 50 11.0 27.5
28 Oryzias latipes Japanese medaka 0.1166 76 4.0 4
29 Plectropomus leopardus Leopard coral trout 0.1671 83 18.0 45.5
30 Poecilia reticulata Guppy 0.0353 33 5.0 9
31 Polypterus senegalus Senegal bichir 0.1721 86 34.0 77
32 Protopterus annectens West african lungfish 0.0845 65 25.0 65.5
33 Salarias fasciatus Jewelled blenny 0.0138 11.5 4.0 4
34 Scleropages formosus Asian arowana 0.0730 59 20.0 55.5
35 Scophthalmus maximus Turbot 0.2437 93 25.0 65.5
36 Siniperca chuatsi Chinese perch 0.0948 71 9.0 18.5
37 Synchiropus splendidus Mandarinfish 0.1415 81 5.0 9
38 Tachysurus fulvidraco Yellow catfish 0.1351 79 8.0 16
39 Tetraodon nigroviridis Green spotted puffer 0.1834 89 10.0 23
40 Xiphophorus hellerii Green swordtail 0.0273 24.5 5.0 9
41 Xiphophorus maculatus Southern platyfish 0.0214 18.5 5.0 9
42 Ailuropoda melanoleuca Giant panda 0.0174 15 38.0 84
43 Canis latrans Coyote 0.0214 18.5 18.0 45.5
44 Felis catus Domestic cat 0.0299 28 38.0 84
45 Mustela putorius furo Domestic ferret 0.0907 69 14.0 34.5
46 Neovison vison American mink 0.0246 21 10.0 23
47 Paguma larvata Masked palm civet 0.0016 1 20.0 50.5
48 Ambystoma mexicanum Axolotl 0.0322 29 20.0 55.5
49 Pleurodeles waltl Iberian ribbed newt 0.0345 30 20.0 55.5
50 Xenopus laevis African clawed frog 0.0947 70 30.0 72
51 Anas platyrhynchos Mallard 0.0236 20 29.0 69
52 Lonchura striata domestica Society finch 0.0044 3 10.0 23
53 Melopsittacus undulatus Budgerigar 0.0194 16 21.0 59.5
54 Struthio camelus Common ostrich 0.0199 17 62.0 94
55 Taeniopygia guttata Zebra finch 0.0432 42 14.0 34.5
56 Anolis carolinensis Green anole 0.0084 7 7.2 14
57 Chrysemys picta Painted turtle 0.0053 4 61.0 93
58 Mauremys mutica Asian yellow pond turtle 0.0122 10 30.0 72
59 Mauremys reevesii Chinese pond turtle 0.0152 13 25.0 65.5
60 Pelodiscus sinensis Chinese softshell turtle 0.0113 9 30.0 72
61 Pogona vitticeps Central bearded dragon 0.1387 80 15.0 38.5
62 Aotus nancymaae Nancy ma's night monkey 0.0366 35 20.0 50.5
63 Callithrix jacchus Common marmoset 0.3186 95 16.5 43
64 Chlorocebus sabaeus Green monkey 0.0599 52 30.1 75
65 Gorilla gorilla Western gorilla 0.0477 45 60.3 92
66 Homo sapiens Human 0.1219 77 122.6 96
67 Macaca fascicularis Crab-eating macaque 0.1132 75 38.4 86
68 Macaca mulatta Rhesus macaque 0.0848 66 40.0 88
69 Macaca nemestrina Pig-tailed macaque 0.0468 44 37.0 79
70 Microcebus murinus Gray mouse lemur 0.1800 87 18.2 48
71 Otolemur garnettii Small-eared galago 0.0518 47 18.0 45.5
72 Pan paniscus Bonobo 0.0071 6 60.0 91
73 Pan troglodytes Common chimpanzee 0.0355 34 68.1 95
74 Papio anubis Olive baboon 0.0371 36 37.5 82
75 Papio hamadryas Hamadryas baboon 0.0873 67 35.6 78
76 Saimiri sciureus Common squirrel monkey 0.0349 31 31.0 76
77 Atelerix albiventris Four-toed hedgehog 0.0298 27 11.0 27.5
78 Dasypus novemcinctus Nine-banded armadillo 0.0278 26 20.0 55.5
79 Oryctolagus cuniculus European rabbit 0.0260 23 12.0 31
80 Tupaia belangeri Northern tree shrew 0.0060 5 12.0 31
81 Bos taurus Cattle 0.0138 11.5 22.0 61.5
82 Equus asinus Donkey 0.1686 85 40.0 88
83 Ovis aries Domestic sheep 0.1674 84 20.0 55.5
84 Sus scrofa Pig 0.0964 72 27.0 68
85 Vicugna pacos Alpaca 0.0492 46 23.0 63
86 Cavia porcellus Guinea pig 0.0814 63 12.0 31
87 Chinchilla lanigera Long-tailed chinchilla 0.0255 22 20.0 50.5
88 Heterocephalus glaber Naked mole rat 0.1900 90 37.0 80.5
89 Mus musculus House mouse 0.1806 88 4.0 4
90 Rattus norvegicus Norway rat 0.2281 92 3.8 2
91 Urocitellus parryii Arctic ground squirrel 0.0351 32 9.0 18.5
92 Cynopterus sphinx Greater short-nosed fruit bat 0.0644 53 12.0 31
93 Myotis ricketti Rickett's big-footed bat 0.0162 14 20.0 50.5
94 Rhinolophus affinis Intermediate horseshoe bat 0.0027 2 15.0 38.5
95 Rhinolophus sinicus Chinese rufous horseshoe bat 0.0719 58 15.0 38.5
96 Rousettus leschenaultii Leschenault's rousette 0.0441 43 22.0 61.5