Evolutionary lifespan atlas
Longevity Cross-Species Cell Atlas
Explore single-cell atlases across long-lived and short-lived species. Understand the cellular mechanisms of longevity from an evolutionary perspective — from killifish to naked mole-rats, bats to bowhead whales.
Section Overview
The Longevity section is LACA's core species atlas hub — a unified portal for exploring single-cell transcriptomic atlases across species with dramatically different lifespans.
Why do naked mole-rats live ~30 years while similarly-sized mice live only ~3? How do bowhead whales maintain cellular health for over 200 years? What can the turquoise killifish — with a lifespan of merely 4 months — teach us about accelerated aging?
The Longevity section addresses these questions by providing high-quality, uniformly-processed single-cell transcriptomic data across 134 species. Each species atlas includes tissue-level UMAP visualizations, cell type annotations, marker gene expression profiles, and cross-species comparative views. By studying nature's extremes — from the shortest-lived vertebrates to the longest — we uncover the molecular strategies that evolution has sculpted to regulate lifespan.
All data is processed through a standardized bioinformatics pipeline ensuring cross-species comparability. Dive into individual species atlases, compare tissue composition across species, or explore longevity-associated biomarkers validated across the tree of life.
What's Inside
Six connected entry points for exploring longevity data and analyses.
Atlas
Browse the canonical LACA species inventory and enter system-, tissue-, and cell-level atlases backed by the data available for each organism.
Browse AtlasCohort
Explore cohort-level datasets and their donor, age, health, tissue, and assay context before interpreting within- or cross-species longevity patterns.
Browse CohortsBiomarker
Review longevity-associated genes and pathways with their evidence, dataset scope, cross-species context, and interpretation limits.
Explore BiomarkersMaps
Open the existing LACA map workspace to navigate atlas-level views for the selected species, beginning with the published human route.
Open MapsGenotype
Browse SNP and INDEL records from single-cell whole-genome sequencing datasets across 16 mammalian species through the migrated, LACA-native genotype interface.
Browse GenotypesCellType
Rank cell populations by the observed relative-expression score of the current longevity gene signature, with dataset scope and statistical interpretation limits kept visible.
Explore Cell TypesHow to Use This Section
A recommended workflow for exploring longevity atlases.
Tissue & Cell View
Dive into tissue-level UMAPs and cell type composition for your chosen species
BioMarker Cross-Ref
Cross-reference with the Longevity BioMarker to find lifespan-associated genes
longevity-biomarker.php →Cross-Species Compare
Use Cross-Species tools to compare your findings across multiple species
genecompare.php →