Tyshkovskiy et al., Cell 2023 ยท SP121 human atlas
Longevity and aging
Cross-species RNA-seq from the 2023 longevity study, shown next to 15- and 12-gene scores on the SP121 human cell atlas. The six pages below share that literature source and that human atlas.
What is on these pages
Longevity here means expression programs that differ between short- and long-lived mammals in Tyshkovskiy et al., Cell 2023. Aging means how those programs change with age, including 15- and 12-gene scores on the SP121 human atlas (1,246,365 cells).
The six pages use that paper and that atlas. They report associations and deposited matrices. They do not rank drugs or treat a conserved signature as a therapy.
Six pages
Correlation
Spearman ฯ of 15-gene longevity vs 12-gene aging scores in SP121 (system, tissue, cell type).
OpenProfiles
GSE227359 (48 samples) and GSE227358 (42 samples) count matrices from the 2023 study.
OpenMechanism
Four literature programs: IGF1/insulin, mitochondria, proteostasis/DNA repair, innate immunity.
OpenRelationship
Same genes plotted by longevity direction vs aging direction (reinforcing, divergent, counteracting).
OpenInterventions
CR, rapamycin, GHR-KO, KU0063794, metformin. Target expression in SP121, not efficacy.
OpenCrosstalk
Ligandโreceptor expression support in SP121 across 19 pathways (CellChatDB; no permutation test).
Open