A curated collection of genes experimentally validated to promote human longevity and healthy aging, sourced from GWAS, candidate gene studies, and centenarian cohorts across global populations.
| Gene Symbol | Pathway | PMID | Journal | Year | Evidence |
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Only APOE and FOXO3 have been consistently replicated across nearly all longevity GWAS studies worldwide, making them the most robust longevity-associated genes identified to date.
Recent 2026 research published in Science estimates that approximately 55% of human lifespan is heritable — significantly higher than the previous estimate of 10–25%, reshaping our understanding of longevity genetics.
Rare variants such as SIRT6 N308K/A313S are found enriched in Ashkenazi Jewish centenarians. These functional variants enhance genome stability and represent promising targets for aging intervention.