⚙ How is this computed? Methods: Data Formats
Analysis Complete

Analysis Results Major002CT001A

Published legacy analysis modules for the selected page.

Species: SP239
Cell Type: Major002CT001A
Generated: 2026-08-07 23:48
Modules: 5
📊 Cell Type Level
📡
3,758
Cell Interactions
🧬
106
TF-Target Pairs
📊
1,343
Significant DEGs
🎯
126
GO Terms
🛤️
112
KEGG Pathways
🔗
30
Co-exp Modules
⚗️
—
Metab. Pathways
🏥
6
Disease Links
💊
—
Drugs Matched
📡 Cell Communication ✓ 🧬 GRN Analysis ✓ 🔗 Co-expression ✓ 🔀 Trajectory Not computed 📊 DEG Analysis ✓ 🎯 GO / KEGG Not computed 🧪 ToppGene Not computed 🔠 Motif Not computed ⚗️ Metabolism Not computed 🏥 Disease ✓ 💊 Drug Analysis Not computed 📄 Full Report
📡

Cell-Cell CommunicationLigand-Receptor Interaction Analysis via CellChat / CellPhoneDB

🔢
Total Interactions
3,758
Significant ligand-receptor pairs
🛤️
Signaling Pathways
27
Unique pathways detected
📤
Top Sender
5
Most active signaling cell type
📥
Top Receiver
13
Most active receiving cell type
Communication Heatmap

Communication Heatmap

Overall interaction strength between cell types. Rows = sender, columns = receiver.

🔍 Full Size
Communication Network

Communication Network

Network visualization of top 50 cell-cell interactions. Node size = connectivity degree.

🔍 Full Size
Signaling Pathway Activity

Signaling Pathway Activity

Top signaling pathways ranked by total communication score.

🔍 Full Size

📋 Top Ligand-Receptor Interactions

📥 All Interactions 📥 Pathway Summary
source target ligand receptor pathway ligand_expr receptor_expr score
9 9 TGFB1 TGFBR1 TGFb 0.1616 0.117 0.0189
9 2 TGFB1 TGFBR1 TGFb 0.1616 0.162 0.0262
9 11 TGFB1 TGFBR1 TGFb 0.1616 0.1853 0.0299
9 5 TGFB1 TGFBR1 TGFb 0.1616 0.1863 0.0301
9 12 TGFB1 TGFBR1 TGFb 0.1616 0.2685 0.0434
9 4 TGFB1 TGFBR1 TGFb 0.1616 0.2934 0.0474
9 7 TGFB1 TGFBR1 TGFb 0.1616 0.2278 0.0368
9 6 TGFB1 TGFBR1 TGFb 0.1616 0.2517 0.0407
9 0 TGFB1 TGFBR1 TGFb 0.1616 0.1821 0.0294
9 1 TGFB1 TGFBR1 TGFb 0.1616 0.1821 0.0294
9 10 TGFB1 TGFBR1 TGFb 0.1616 0.2532 0.0409
9 3 TGFB1 TGFBR1 TGFb 0.1616 0.2413 0.039
Showing top 12 rows · Download full table above
🧬

Gene Regulatory NetworkTranscription Factor Activity & TF-Target Inference (pySCENIC / DoRothEA)

🎛️
TFs Analyzed
90
Transcription factors profiled
🔗
TF-Target Pairs
106
Significant regulatory relationships

Top Regulatory TFs

FOS 37 targets
JUN 17 targets
LEF1 16 targets
IRF1 6 targets
MYC 5 targets
TCF7 4 targets
GATA3 3 targets
E2F1 3 targets
RUNX2 3 targets
EGR1 2 targets
TF Activity Heatmap

TF Activity Heatmap

Z-score normalized TF expression across cell populations.

🔍 Full Size 📥 TF Activity 📥 TF-Target Pairs
Gene Regulatory Network

Gene Regulatory Network

Red nodes: TFs. Blue: targets. Green edge: activation. Red edge: repression.

🔍 Full Size 📥 TF Activity 📥 TF-Target Pairs
🔗

Gene Co-expression NetworkWGCNA-style Module Analysis (hdWGCNA)

📦
Modules Identified
30
Co-expression gene modules
🧬
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram

Module Dendrogram

Hierarchical clustering of co-expression modules based on topological overlap.

🔍 Full Size 📥 Gene Modules 📥 Eigengenes
Module-Cell Type Association

Module-Cell Type Association

Module eigengene activity across cell types.

🔍 Full Size 📥 Gene Modules 📥 Eigengenes
📊

Differential ExpressionCell Type Marker Genes (Wilcoxon / MAST)

📈
Significant DEGs
1,343
Genes passing adj. p < 0.05 & |log2FC| > 0.5
🏷️
Cell Types Compared
N/A
Cell populations analyzed
Volcano Plot

Volcano Plot

Log2 fold change vs significance. Red: up-regulated. Blue: down-regulated.

Marker Gene Heatmap

Marker Gene Heatmap

Z-score normalized expression of top marker genes per cell type.

📋 Top Marker Genes

📥 Top Markers 📥 All Significant DEGs 📥 Full DEG Results
names scores logfoldchanges pvals pvals_adj pct_nz_group pct_nz_reference cell_type
TXNIP 97.9078 3.4383 0 0 0.978 0.5182 B_00_NR1D2
ZFP36L2 100.9553 3.0754 0 0 0.9878 0.6554 B_00_NR1D2
SAP30 33.5686 2.8319 0 0 0.3521 0.0739 B_00_NR1D2
TP53INP1 83.6129 2.8089 0 0 0.9541 0.5115 B_00_NR1D2
KLF2 63.2278 2.6731 0 0 0.7493 0.2424 B_00_NR1D2
NFKBIA 77.8952 2.6087 0 0 0.9521 0.53 B_00_NR1D2
RGS1 66.98 2.3768 0 0 0.9716 0.6615 B_00_NR1D2
CDKN1A 51.433 2.3631 0 0 0.6367 0.2172 B_00_NR1D2
TMEM158 43.1982 2.3422 0 0 0.5135 0.1517 B_00_NR1D2
PIM1 53.1262 2.1907 0 0 0.6946 0.273 B_00_NR1D2
APOA1 87.9942 5.9558 0 0 0.8829 0.0574 B_01_KLF6
APOA4 66.8295 5.2375 0 0 0.6753 0.048 B_01_KLF6
Showing top 12 rows
🏥

Disease AssociationDisease Gene Enrichment (scDRS / DisGeNET / OMIM / ToppGene)

🔬
Diseases Tested
15
Disease categories analyzed
✅
Significant Associations
6
Cell type-disease links (adj. p < 0.05)

Top Associated Diseases

Systemic lupus erythematosus Rheumatoid arthritis Multiple sclerosis Cardiovascular disease Parkinson disease
Disease Association Heatmap

Disease Association Heatmap

-Log10(P-value) of disease gene enrichment per cell type.

Top Disease Associations

Top Disease Associations

Dot size: overlap genes. Color: significance.

📥 Disease Enrichment Data
📄

Full Analysis ReportComprehensive Summary & Downloads

📊

Interactive HTML Report

Complete analysis report with all figures, key findings, and data summaries in a standalone HTML page.

📄 Open Report
📦

Download All Results

Download all analysis results including CSV data, PNG figures, and JSON summaries as a compressed archive.

📥 Download ZIP
🔗

Share Results

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analysis.php?SP_ID=SP239&ctID=Major002CT001A

📁 Available Result Files

Analysis File Type Action
Cell Communication cellchat_heatmap.png Figure (PNG) 🔍 View
Cell Communication cellchat_network.png Figure (PNG) 🔍 View
Cell Communication cellchat_pathway_dotplot.png Figure (PNG) 🔍 View
Cell Communication cellchat_interactions.csv Data (CSV) 📥 Download
Cell Communication cellchat_pathway_summary.csv Data (CSV) 📥 Download
GRN Analysis grn_tf_heatmap.png Figure (PNG) 🔍 View
GRN Analysis grn_network.png Figure (PNG) 🔍 View
GRN Analysis grn_tf_activity.csv Data (CSV) 📥 Download
GRN Analysis grn_tf_targets.csv Data (CSV) 📥 Download
Co-expression coexp_dendrogram.png Figure (PNG) 🔍 View
Co-expression coexp_module_heatmap.png Figure (PNG) 🔍 View
Co-expression coexp_modules.csv Data (CSV) 📥 Download
Co-expression coexp_eigengenes.csv Data (CSV) 📥 Download
DEG Analysis deg_volcano.png Figure (PNG) 🔍 View
DEG Analysis deg_marker_heatmap.png Figure (PNG) 🔍 View
DEG Analysis deg_top_markers.csv Data (CSV) 📥 Download
DEG Analysis deg_significant.csv Data (CSV) 📥 Download
DEG Analysis deg_all_results.csv Data (CSV) 📥 Download
Disease disease_heatmap.png Figure (PNG) 🔍 View
Disease disease_dotplot.png Figure (PNG) 🔍 View
Disease disease_enrichment.csv Data (CSV) 📥 Download
Report Major002CT001A_analysis_report.html Report (HTML) 📄 Open
Report Major002CT001A_summary.json Summary (JSON) 📥 Download