Total Interactions
2,599
Significant ligand-receptor pairs
Analysis Complete
Analysis Results sys07tis05
Published legacy analysis modules for the selected page.
๐ Tissue Level
Cell Communication
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GRN Analysis
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Co-expression
โ
Trajectory
Not computed
DEG Analysis
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GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Not computed
Disease
โ
Drug Analysis
Not computed
Full Report
Cell-Cell CommunicationLigand-Receptor Interaction Analysis via CellChat / CellPhoneDB
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๐ค๏ธ
Signaling Pathways
27
Unique pathways detected
๐ค
Top Sender
Macrophages
Most active signaling cell type
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Top Receiver
Mast cells
Most active receiving cell type
Communication Heatmap
Overall interaction strength between cell types. Rows = sender, columns = receiver.
Communication Network
Network visualization of top 50 cell-cell interactions. Node size = connectivity degree.
Signaling Pathway Activity
Top signaling pathways ranked by total communication score.
๐ Top Ligand-Receptor Interactions
| source | target | ligand | receptor | pathway | ligand_expr | receptor_expr | score |
|---|---|---|---|---|---|---|---|
| Fibroblasts | Fibroblasts | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.2056 | 0.0019 |
| Fibroblasts | Mast cells | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.1771 | 0.0016 |
| Fibroblasts | Adipocytes | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.1571 | 0.0014 |
| Fibroblasts | Macrophages | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.1159 | 0.001 |
| Fibroblasts | Pericytes | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.1248 | 0.0011 |
| Fibroblasts | Endothelial cells | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.1032 | 0.0009 |
| Fibroblasts | DN T cells | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.1217 | 0.0011 |
| Fibroblasts | Mesothelial cells | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.1138 | 0.001 |
| Fibroblasts | Schwann cells | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.1197 | 0.0011 |
| Fibroblasts | Adipocyte progenitor cells | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.1574 | 0.0014 |
| Fibroblasts | Smooth muscle cells | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.1891 | 0.0017 |
| Fibroblasts | Neutrophils | TGFB1 | TGFBR1 | TGFb | 0.009 | 0.0432 | 0.0004 |
Showing top 12 rows ยท Download full table above
Gene Regulatory NetworkTranscription Factor Activity & TF-Target Inference (pySCENIC / DoRothEA)
๐๏ธ
TFs Analyzed
90
Transcription factors profiled
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TF-Target Pairs
62
Significant regulatory relationships
Top Regulatory TFs
RUNX1
37 targets
LEF1
9 targets
TCF7
4 targets
HNF4A
4 targets
IRF4
3 targets
RUNX2
2 targets
CEBPB
1 targets
GATA3
1 targets
BATF
1 targets
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Gene Regulatory Network
Red nodes: TFs. Blue: targets. Green edge: activation. Red edge: repression.
Gene Co-expression NetworkWGCNA-style Module Analysis (hdWGCNA)
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of co-expression modules based on topological overlap.
Module-Cell Type Association
Module eigengene activity across cell types.
Differential ExpressionCell Type Marker Genes (Wilcoxon / MAST)
๐
Significant DEGs
1,184
Genes passing adj. p < 0.05 & |log2FC| > 0.5
๐ท๏ธ
Cell Types Compared
12
Cell populations analyzed
Volcano Plot
Log2 fold change vs significance. Red: up-regulated. Blue: down-regulated.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| SLC16A12 | 59.1459 | 2.2847 | 0 | 0 | 0.6126 | 0.2309 | Adipocyte progenitor cells |
| FKBP5 | 91.6564 | 2.2096 | 0 | 0 | 0.9874 | 0.7783 | Adipocyte progenitor cells |
| ACACB | 67.753 | 2.1344 | 0 | 0 | 0.8872 | 0.4788 | Adipocyte progenitor cells |
| TSHR | 81.1243 | 2.0935 | 0 | 0 | 0.985 | 0.6686 | Adipocyte progenitor cells |
| HMGXB4 | 53.844 | 2.0914 | 0 | 0 | 0.573 | 0.2084 | Adipocyte progenitor cells |
| LGR5 | 55.9538 | 2.0289 | 0 | 0 | 0.6524 | 0.2912 | Adipocyte progenitor cells |
| STK39 | 79.5392 | 2.0078 | 0 | 0 | 0.9756 | 0.6845 | Adipocyte progenitor cells |
| PDK4 | 69.0176 | 1.985 | 0 | 0 | 0.9724 | 0.676 | Adipocyte progenitor cells |
| NET1 | 62.0149 | 1.9586 | 0 | 0 | 0.7737 | 0.3771 | Adipocyte progenitor cells |
| NAMPT | 55.3484 | 1.9372 | 0 | 0 | 0.6515 | 0.2859 | Adipocyte progenitor cells |
| LPIN1 | 88.9668 | 2.0093 | 0 | 0 | 0.8872 | 0.5395 | Adipocytes |
| PRKAR2B | 111.0573 | 1.9797 | 0 | 0 | 0.9662 | 0.7258 | Adipocytes |
Showing top 12 rows
Disease AssociationDisease Gene Enrichment (scDRS / DisGeNET / OMIM / ToppGene)
๐ฌ
Diseases Tested
15
Disease categories analyzed
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Significant Associations
9
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
-Log10(P-value) of disease gene enrichment per cell type.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Full Analysis ReportComprehensive Summary & Downloads
Interactive HTML Report
Complete analysis report with all figures, key findings, and data summaries in a standalone HTML page.
๐ Open ReportDownload All Results
Download all analysis results including CSV data, PNG figures, and JSON summaries as a compressed archive.
๐ฅ Download ZIPShare Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP239&tisID=sys07tis05
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| Cell Communication | cellchat_heatmap.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_network.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_pathway_dotplot.png | Figure (PNG) | ๐ View |
| Cell Communication | cellchat_interactions.csv | Data (CSV) | ๐ฅ Download |
| Cell Communication | cellchat_pathway_summary.csv | Data (CSV) | ๐ฅ Download |
| GRN Analysis | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| GRN Analysis | grn_network.png | Figure (PNG) | ๐ View |
| GRN Analysis | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| GRN Analysis | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_volcano.png | Figure (PNG) | ๐ View |
| DEG Analysis | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| DEG Analysis | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| DEG Analysis | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Report | sys07tis05_analysis_report.html | Report (HTML) | ๐ Open |
| Report | sys07tis05_summary.json | Summary (JSON) | ๐ฅ Download |