Analysis Complete

Analysis Results sys10tis02

Published legacy analysis modules for the selected page.

Species: SP239

Tissue: sys10tis02

Generated: 2026-08-07 23:48

Modules: 5

📊 Tissue Level

📡

4,661

Cell Interactions

🧬

564

TF-Target Pairs

📊

1,599

Significant DEGs

🎯

144

GO Terms

🛤️

128

KEGG Pathways

🔗

Co-exp Modules

⚗️

—

Metab. Pathways

🏥

Disease Links

💊

—

Drugs Matched

📡 Cell Communication ✓ 🧬 GRN Analysis ✓ 🔗 Co-expression ✓ 🔀 Trajectory Not computed 📊 DEG Analysis ✓ 🎯 GO / KEGG Not computed 🧪 ToppGene Not computed 🔠 Motif Not computed ⚗️ Metabolism Not computed 🏥 Disease ✓ 💊 Drug Analysis Not computed 📄 Full Report

📡

Cell-Cell CommunicationLigand-Receptor Interaction Analysis via CellChat / CellPhoneDB

🔢

Total Interactions

4,661

Significant ligand-receptor pairs

🛤️

Signaling Pathways

Unique pathways detected

📤

Top Sender

Macrophages

Most active signaling cell type

📥

Top Receiver

Dendritic cells

Most active receiving cell type

Communication Heatmap

Overall interaction strength between cell types. Rows = sender, columns = receiver.

🔍 Full Size

Communication Network

Network visualization of top 50 cell-cell interactions. Node size = connectivity degree.

🔍 Full Size

Signaling Pathway Activity

Top signaling pathways ranked by total communication score.

🔍 Full Size

📋 Top Ligand-Receptor Interactions

📥 All Interactions 📥 Pathway Summary

source	target	ligand	receptor	pathway	ligand_expr	receptor_expr	score
Keratinocytes	Keratinocytes	TGFB1	TGFBR1	TGFb	0.083	0.2289	0.019
Keratinocytes	Endothelial cells	TGFB1	TGFBR1	TGFb	0.083	0.3037	0.0252
Keratinocytes	Fibroblasts	TGFB1	TGFBR1	TGFb	0.083	0.5445	0.0452
Keratinocytes	Pericytes	TGFB1	TGFBR1	TGFb	0.083	0.5129	0.0426
Keratinocytes	DN T cells	TGFB1	TGFBR1	TGFb	0.083	0.1988	0.0165
Keratinocytes	Schwann cells	TGFB1	TGFBR1	TGFb	0.083	0.323	0.0268
Keratinocytes	Macrophages	TGFB1	TGFBR1	TGFb	0.083	0.1883	0.0156
Keratinocytes	CD4+ T cells	TGFB1	TGFBR1	TGFb	0.083	0.2483	0.0206
Keratinocytes	Sebocytes	TGFB1	TGFBR1	TGFb	0.083	0.3663	0.0304
Keratinocytes	Melanocytes	TGFB1	TGFBR1	TGFb	0.083	0.2235	0.0186
Keratinocytes	CD8+ T cells	TGFB1	TGFBR1	TGFb	0.083	0.253	0.021
Keratinocytes	Dendritic cells	TGFB1	TGFBR1	TGFb	0.083	0.2571	0.0213

Showing top 12 rows · Download full table above

🧬

Gene Regulatory NetworkTranscription Factor Activity & TF-Target Inference (pySCENIC / DoRothEA)

🎛️

TFs Analyzed

Transcription factors profiled

🔗

TF-Target Pairs

564

Significant regulatory relationships

Top Regulatory TFs

GATA3 122 targets

CEBPA 65 targets

NFKB1 54 targets

RUNX1 45 targets

IRF1 33 targets

BATF 27 targets

TP53 27 targets

RUNX2 26 targets

EGR1 23 targets

CEBPB 19 targets

TF Activity Heatmap

Z-score normalized TF expression across cell populations.

🔍 Full Size 📥 TF Activity 📥 TF-Target Pairs

Gene Regulatory Network

Red nodes: TFs. Blue: targets. Green edge: activation. Red edge: repression.

🔍 Full Size 📥 TF Activity 📥 TF-Target Pairs

🔗

Gene Co-expression NetworkWGCNA-style Module Analysis (hdWGCNA)

📦

Modules Identified

Co-expression gene modules

🧬

Genes Analyzed

2,000

Highly variable genes

Module Dendrogram

Hierarchical clustering of co-expression modules based on topological overlap.

🔍 Full Size 📥 Gene Modules 📥 Eigengenes

Module-Cell Type Association

Module eigengene activity across cell types.

🔍 Full Size 📥 Gene Modules 📥 Eigengenes

📊

Differential ExpressionCell Type Marker Genes (Wilcoxon / MAST)

📈

Significant DEGs

1,599

Genes passing adj. p < 0.05 & |log2FC| > 0.5

🏷️

Cell Types Compared

Cell populations analyzed

Volcano Plot

Log2 fold change vs significance. Red: up-regulated. Blue: down-regulated.

Marker Gene Heatmap

Z-score normalized expression of top marker genes per cell type.

📋 Top Marker Genes

📥 Top Markers 📥 All Significant DEGs 📥 Full DEG Results

names	scores	logfoldchanges	pct_nz_group	pct_nz_reference	cell_type
CD4	6.5508	7.7507	0.4697	0.0057	CD4+ T cells
CD3E	9.4599	7.5815	0.6818	0.0122	CD4+ T cells
RGS1	11.7982	7.5798	0.8636	0.0621	CD4+ T cells
CD3G	9.465	7.4769	0.6818	0.0108	CD4+ T cells
SLAMF6	9.0364	7.2722	0.6515	0.0125	CD4+ T cells
IL7R	10.5514	7.0989	0.7727	0.0257	CD4+ T cells
CD3D	10.015	6.805	0.7273	0.0287	CD4+ T cells
PTPRC	12.6046	6.5116	0.9394	0.0957	CD4+ T cells
CD247	6.4837	6.5018	0.4697	0.0123	CD4+ T cells
CD69	8.5225	6.4301	0.6212	0.0171	CD4+ T cells
IL7R	13.7042	8.3788	0.971	0.0253	CD8+ T cells
CD3E	12.5639	8.148	0.8841	0.0119	CD8+ T cells

Showing top 12 rows

🏥

Disease AssociationDisease Gene Enrichment (scDRS / DisGeNET / OMIM / ToppGene)

🔬

Diseases Tested

Disease categories analyzed

✅

Significant Associations

Cell type-disease links (adj. p < 0.05)

Top Associated Diseases

Multiple sclerosis Systemic lupus erythematosus Multiple sclerosis Multiple sclerosis Systemic lupus erythematosus

Disease Association Heatmap

-Log10(P-value) of disease gene enrichment per cell type.

Top Disease Associations

Dot size: overlap genes. Color: significance.

📥 Disease Enrichment Data

📄

Full Analysis ReportComprehensive Summary & Downloads

📊

Interactive HTML Report

Complete analysis report with all figures, key findings, and data summaries in a standalone HTML page.

📄 Open Report

📦

Download All Results

Download all analysis results including CSV data, PNG figures, and JSON summaries as a compressed archive.

📥 Download ZIP

🔗

Share Results

Use this permanent link to share these analysis results:


                analysis.php?SP_ID=SP239&tisID=sys10tis02

📁 Available Result Files

Analysis	File	Type	Action
Cell Communication	cellchat_heatmap.png	Figure (PNG)	🔍 View
Cell Communication	cellchat_network.png	Figure (PNG)	🔍 View
Cell Communication	cellchat_pathway_dotplot.png	Figure (PNG)	🔍 View
Cell Communication	cellchat_interactions.csv	Data (CSV)	📥 Download
Cell Communication	cellchat_pathway_summary.csv	Data (CSV)	📥 Download
GRN Analysis	grn_tf_heatmap.png	Figure (PNG)	🔍 View
GRN Analysis	grn_network.png	Figure (PNG)	🔍 View
GRN Analysis	grn_tf_activity.csv	Data (CSV)	📥 Download
GRN Analysis	grn_tf_targets.csv	Data (CSV)	📥 Download
Co-expression	coexp_dendrogram.png	Figure (PNG)	🔍 View
Co-expression	coexp_module_heatmap.png	Figure (PNG)	🔍 View
Co-expression	coexp_modules.csv	Data (CSV)	📥 Download
Co-expression	coexp_eigengenes.csv	Data (CSV)	📥 Download
DEG Analysis	deg_volcano.png	Figure (PNG)	🔍 View
DEG Analysis	deg_marker_heatmap.png	Figure (PNG)	🔍 View
DEG Analysis	deg_top_markers.csv	Data (CSV)	📥 Download
DEG Analysis	deg_significant.csv	Data (CSV)	📥 Download
DEG Analysis	deg_all_results.csv	Data (CSV)	📥 Download
Disease	disease_heatmap.png	Figure (PNG)	🔍 View
Disease	disease_dotplot.png	Figure (PNG)	🔍 View
Disease	disease_enrichment.csv	Data (CSV)	📥 Download
Report	sys10tis02_analysis_report.html	Report (HTML)	📄 Open
Report	sys10tis02_summary.json	Summary (JSON)	📥 Download