TFs Analyzed
64
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP491
Published legacy analysis modules for the selected page.
๐ Species Level
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=1,822,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
171
Thresholded Pearson associations
Top TF Association Counts
AHR
29 associations
AR
9 associations
ARNT
8 associations
E2F1
15 associations
ESR1
7 associations
IRF1
10 associations
LEF1
10 associations
SOX2
21 associations
TCF7
7 associations
VDR
8 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
694
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
7
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| SLC15A2 | 14.2207 | 6.2512 | 0 | 0 | 0.5333 | 0.0204 | Astrocytes |
| SLC1A2 | 25.4838 | 6.1087 | 0 | 0 | 0.9667 | 0.2976 | Astrocytes |
| BMPR1B | 18.2692 | 6.0966 | 0 | 0 | 0.6933 | 0.0493 | Astrocytes |
| MLC1 | 12.6235 | 6.0254 | 0 | 0 | 0.4733 | 0.0171 | Astrocytes |
| ACSBG1 | 13.415 | 5.7939 | 0 | 0 | 0.5067 | 0.0269 | Astrocytes |
| SLC4A1 | 23.2919 | 5.4982 | 0 | 0 | 0.91 | 0.2057 | Astrocytes |
| SLC13A5 | 11.0637 | 5.4476 | 0 | 0 | 0.42 | 0.0223 | Astrocytes |
| SLC6A11 | 21.0644 | 5.3596 | 0 | 0 | 0.8267 | 0.1754 | Astrocytes |
| AQP4 | 15.1421 | 5.275 | 0 | 0 | 0.5833 | 0.0447 | Astrocytes |
| FGFR3 | 14.1232 | 5.2284 | 0 | 0 | 0.5433 | 0.0407 | Astrocytes |
| SLIT3 | 19.4108 | 4.3591 | 0 | 0 | 0.8167 | 0.2043 | Excitatory neurons |
| SLC17A6 | 18.456 | 4.3215 | 0 | 0 | 0.77 | 0.1117 | Excitatory neurons |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
12
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
7
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
5
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
15
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
7
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Microglia | Kinase inhibitor | CML / GIST | 5 | 5 | 0.3522 | 57.4713 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Fibroblasts | Kinase inhibitor | CML / GIST | 5 | 5 | 0.279 | 47.541 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Astrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0917 | 18.6667 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Oligodendrocyte progenitor cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.3766 | 61.3333 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Oligodendrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0504 | 10.3333 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Inhibitory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.072 | 23 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Excitatory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0878 | 24 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Trastuzumab | Microglia | mAb | Breast cancer | 1 | 1 | 0 | 0 | 0 | ERBB2 |
| Trastuzumab | Fibroblasts | mAb | Breast cancer | 1 | 1 | 0 | 0 | 0 | ERBB2 |
| Trastuzumab | Astrocytes | mAb | Breast cancer | 1 | 1 | 0 | 0 | 0 | ERBB2 |
| Trastuzumab | Oligodendrocyte progenitor cells | mAb | Breast cancer | 1 | 1 | 0 | 0 | 0 | ERBB2 |
| Trastuzumab | Oligodendrocytes | mAb | Breast cancer | 1 | 1 | 0.0086 | 0.3333 | 0 | ERBB2 |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP491
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP491_summary.json | Summary (JSON) | ๐ฅ Download |