TFs Analyzed
69
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP492
Published legacy analysis modules for the selected page.
๐ Species Level
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=2,443,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
293
Thresholded Pearson associations
Top TF Association Counts
CEBPB
39 associations
EGR1
13 associations
ESR1
18 associations
GATA2
8 associations
IRF1
65 associations
LEF1
32 associations
MYC
11 associations
PAX6
7 associations
SOX2
23 associations
SOX9
32 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
900
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
9
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| SLC13A5 | 14.3505 | 6.793 | 0 | 0 | 0.52 | 0.0117 | Astrocytes |
| GPC5 | 25.7225 | 5.7713 | 0 | 0 | 0.9733 | 0.4088 | Astrocytes |
| SLC1A2 | 25.4715 | 5.6955 | 0 | 0 | 0.9533 | 0.2823 | Astrocytes |
| GRK5 | 22.9478 | 4.9055 | 0 | 0 | 0.89 | 0.2338 | Astrocytes |
| APOA1 | 20.0984 | 4.7114 | 0 | 0 | 0.81 | 0.1965 | Astrocytes |
| ACSBG1 | 16.2709 | 4.692 | 0 | 0 | 0.6367 | 0.0649 | Astrocytes |
| TRDN | 10.1752 | 4.5538 | 0 | 0 | 0.3933 | 0.0397 | Astrocytes |
| SLC1A3 | 21.1134 | 4.5377 | 0 | 0 | 0.85 | 0.2259 | Astrocytes |
| EGF | 18.5381 | 4.4733 | 0 | 0 | 0.76 | 0.1073 | Astrocytes |
| RFX4 | 17.8213 | 4.4089 | 0 | 0 | 0.7167 | 0.1185 | Astrocytes |
| EMCN | 12.6715 | 10.2885 | 0 | 0 | 0.6051 | 0.0022 | Endothelial cells |
| FLT1 | 19.6122 | 9.3372 | 0 | 0 | 0.9427 | 0.0245 | Endothelial cells |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
12
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
9
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
4
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
14
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
9
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Oligodendrocyte progenitor cells | Kinase inhibitor | CML / GIST | 4 | 5 | 0.5956 | 78 | 1 | KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Ependymal cells | Kinase inhibitor | CML / GIST | 4 | 5 | 0.0399 | 6.6667 | 0 | KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Fibroblasts | Kinase inhibitor | CML / GIST | 4 | 5 | 0.2197 | 31.1828 | 0 | KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Astrocytes | Kinase inhibitor | CML / GIST | 4 | 5 | 0.102 | 17.6667 | 0 | KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Microglia | Kinase inhibitor | CML / GIST | 4 | 5 | 0.2021 | 32 | 1 | KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Excitatory neurons | Kinase inhibitor | CML / GIST | 4 | 5 | 0.0229 | 7 | 0 | KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Endothelial cells | Kinase inhibitor | CML / GIST | 4 | 5 | 0.0157 | 2.5478 | 0 | KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Oligodendrocytes | Kinase inhibitor | CML / GIST | 4 | 5 | 0.0053 | 1 | 0 | KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Inhibitory neurons | Kinase inhibitor | CML / GIST | 4 | 5 | 0.0146 | 3.6667 | 0 | KIT,PDGFRA,PDGFRB,CSF1R |
| Trastuzumab | Oligodendrocyte progenitor cells | mAb | Breast cancer | 1 | 1 | 0.0067 | 0.3333 | 0 | ERBB2 |
| Trastuzumab | Ependymal cells | mAb | Breast cancer | 1 | 1 | 0.0713 | 3.3333 | 0 | ERBB2 |
| Trastuzumab | Fibroblasts | mAb | Breast cancer | 1 | 1 | 0.0415 | 1.6129 | 0 | ERBB2 |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP492
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP492_summary.json | Summary (JSON) | ๐ฅ Download |