Mapped Gene Set
5/15
Missing genes are not imputed
Exploratory Modules Available
Analysis Results SP522
Validated Atlas overview, cellular composition, and descriptive longevity-gene analysis for the selected page. Linked advanced tabs are validated exploratory outputs from a stratified sample.
๐ Species Level
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=691,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Atlas & Longevity
Ready
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Atlas & Longevity Analysis Validated overview, composition diversity, and descriptive longevity signature
Release r20260808-v4
Partial Longevity Signature (5/15)
Pipeline laca-content-analysis-v2.2.0
N
Mean
Mean Signature Score
0.1413
Mapped-gene relative-expression index
P50
Median Score
0.0921
Across the validated cell universe
P95
95th Percentile
0.4227
Upper descriptive percentile
+
Cells with Any Mapped Gene
82.90%
Detection, not a causal longevity effect
Missing
Unmapped Curated Genes
FOXO3, SIRT6, SIRT1, SIRT3, IGF1R, KLOTHO, APOC3, IL6, TERT, ACE
mapped_genes_only; not_imputed
Composition diversity
| Grouping | Groups | Top group | Top share | Shannon | Simpson | Effective groups |
|---|---|---|---|---|---|---|
| Celltype | 3 | Mic | 84.71% | 0.4777 | 0.2632 | 1.61 |
| Tissue | 1 | Brain | 100.00% | 0.0000 | 0.0000 | 1.00 |
| System | 1 | Unknown | 100.00% | 0.0000 | 0.0000 | 1.00 |
Top cell types
| Name | Cells | Mean | Positive |
|---|---|---|---|
| Ast | 91 | 0.3062 | 95.60% |
| Mic | 4,993 | 0.1529 | 86.60% |
| Neurons | 810 | 0.0512 | 58.64% |
Top tissues
| Name | Cells | Mean | Positive |
|---|---|---|---|
| Brain | 5,894 | 0.1413 | 82.90% |
Top mapped longevity genes
| Gene | Mean expression | Positive cells |
|---|---|---|
| APOE | 2.4689 | 77.55% |
| IRS2 | 0.5380 | 33.37% |
| CETP | 0.3199 | 17.31% |
| TP53 | 0.1166 | 8.72% |
| SHC1 | 0.1064 | 8.35% |
Advanced module status (Atlas plus linked exploratory package)
Age Association
skipped
Independent Sample Metadata Not Available.
Independent Sample Metadata Not Available.
Cellchat
skipped
Cross Tissue Communication Not Inferred.
Cross Tissue Communication Not Inferred.
Coexpression
validated_exploratory
Deterministic tissue x cell-type stratified sample; descriptive only.
Deterministic tissue x cell-type stratified sample; descriptive only.
Differential Expression
validated_exploratory
Deterministic tissue x cell-type stratified sample; descriptive only.
Deterministic tissue x cell-type stratified sample; descriptive only.
Disease
validated_exploratory
Deterministic tissue x cell-type stratified sample; descriptive only.
Deterministic tissue x cell-type stratified sample; descriptive only.
Drug
validated_exploratory
Deterministic tissue x cell-type stratified sample; descriptive only.
Deterministic tissue x cell-type stratified sample; descriptive only.
Enrichment
skipped
Species Specific Gene Id Resources Not Validated.
Species Specific Gene Id Resources Not Validated.
Grn
validated_exploratory
Deterministic tissue x cell-type stratified sample; descriptive only.
Deterministic tissue x cell-type stratified sample; descriptive only.
Metabolism
validated_exploratory
Deterministic tissue x cell-type stratified sample; descriptive only.
Deterministic tissue x cell-type stratified sample; descriptive only.
Motif
skipped
Species Specific Motif Resource Not Validated.
Species Specific Motif Resource Not Validated.
Toppgene
skipped
External Service Not Configured.
External Service Not Configured.
Trajectory
skipped
Species Wide Trajectory Not Biologically Validated.
Species Wide Trajectory Not Biologically Validated.
Descriptive relative-expression scores only. Compare scores only within the same source species and an identical mapped gene set. Higher scores do not imply a pro-longevity direction, and these results do not establish causality.
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
TFs Analyzed
31
Transcription factors profiled
๐
TF-Target Pairs
826
Thresholded Pearson associations
Top TF Association Counts
EGR1
38 associations
FOS
112 associations
GATA1
67 associations
GATA2
68 associations
KLF4
52 associations
MYC
37 associations
SNAI1
38 associations
SOX4
50 associations
TP53
44 associations
VDR
52 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
227
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
3
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| SPARC | 14.0516 | 5.3806 | 0 | 0 | 0.989 | 0.1933 | Ast |
| S100A12 | 12.5522 | 5.3732 | 0 | 0 | 0.8681 | 0.095 | Ast |
| ID3 | 12.8546 | 5.1523 | 0 | 0 | 0.9231 | 0.17 | Ast |
| KRT19 | 13.5463 | 5.0913 | 0 | 0 | 0.989 | 0.185 | Ast |
| SFRP5 | 12.9799 | 4.9727 | 0 | 0 | 0.9231 | 0.1533 | Ast |
| APOE | 10.4828 | 4.8649 | 0 | 0 | 0.9341 | 0.64 | Ast |
| ID1 | 11.8596 | 4.8587 | 0 | 0 | 0.8901 | 0.29 | Ast |
| HES1 | 12.3986 | 4.8002 | 0 | 0 | 0.9231 | 0.2017 | Ast |
| ASL | 11.0151 | 4.6684 | 0 | 0 | 0.8352 | 0.2883 | Ast |
| MAL | 10.0201 | 4.661 | 0 | 0 | 0.7363 | 0.14 | Ast |
| FOXL2 | 6.6944 | 4.6666 | 0 | 0 | 0.32 | 0.0281 | Mic |
| TBX20 | 7.9496 | 4.0275 | 0 | 0 | 0.3867 | 0.0358 | Mic |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
11
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
3
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
3
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
6
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
3
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Neu | Kinase inhibitor | CML / GIST | 2 | 5 | 0.0071 | 1 | 0 | PDGFRB,CSF1R |
| Imatinib | Ast | Kinase inhibitor | CML / GIST | 2 | 5 | 0.0714 | 9.8901 | 0 | PDGFRB,CSF1R |
| Imatinib | Mic | Kinase inhibitor | CML / GIST | 2 | 5 | 0.0116 | 2 | 0 | PDGFRB,CSF1R |
| Ruxolitinib | Neu | JAK inhibitor | MPN | 1 | 2 | 0.0507 | 3 | 0 | JAK2 |
| Ruxolitinib | Ast | JAK inhibitor | MPN | 1 | 2 | 0.1008 | 6.5934 | 0 | JAK2 |
| Ruxolitinib | Mic | JAK inhibitor | MPN | 1 | 2 | 0.0893 | 7.6667 | 0 | JAK2 |
| Erlotinib | Neu | Kinase inhibitor | NSCLC | 1 | 1 | 0.0701 | 5.3333 | 0 | EGFR |
| Erlotinib | Ast | Kinase inhibitor | NSCLC | 1 | 1 | 1.4689 | 69.2308 | 1 | EGFR |
| Erlotinib | Mic | Kinase inhibitor | NSCLC | 1 | 1 | 0.5341 | 30.3333 | 0 | EGFR |
| Ibrutinib | Neu | BTK inhibitor | CLL / MCL | 1 | 1 | 0 | 0 | 0 | BTK |
| Ibrutinib | Ast | BTK inhibitor | CLL / MCL | 1 | 1 | 0 | 0 | 0 | BTK |
| Ibrutinib | Mic | BTK inhibitor | CLL / MCL | 1 | 1 | 0.0034 | 0.3333 | 0 | BTK |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP522
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP522_summary.json | Summary (JSON) | ๐ฅ Download |