TFs Analyzed
71
Transcription factors profiled
Exploratory Modules Available
Analysis Results SP587
Published legacy analysis modules for the selected page.
๐ Species Level
Validated exploratory / stratified sample.
Artifact and provenance checks passed for the linked advanced-module package.
These tabs use a deterministic tissue x cell-type stratified sample
(n=1,487,
seed=20260808) and are descriptive cell-level analyses,
not donor-level inference. Cell communication, species-wide trajectory, and age association remain not computed.
Cell Communication
Not computed
TF Associations
Exploratory
Co-expression
Exploratory
Trajectory
Not computed
Marker Ranking
Exploratory
GO / KEGG
Not computed
ToppGene
Not computed
Motif
Not computed
Metabolism
Exploratory
Disease
Exploratory
Drug Analysis
Exploratory
Full Report
Exploratory TF-Target AssociationsPearson associations in the stratified sample; not causal regulatory inference
๐๏ธ
๐
TF-Target Pairs
194
Thresholded Pearson associations
Top TF Association Counts
BATF
9 associations
E2F1
10 associations
EOMES
7 associations
HIF1A
7 associations
LEF1
23 associations
PAX6
14 associations
PRDM1
14 associations
RUNX1
18 associations
SOX2
15 associations
TCF7
12 associations
TF Activity Heatmap
Z-score normalized TF expression across cell populations.
Exploratory TF-Target Association Network
Pearson TF-target associations in the stratified sample; not a causal regulatory network.
Gene Co-expression NetworkExpression-correlation modules in the stratified sample; descriptive only
๐ฆ
Modules Identified
30
Co-expression gene modules
๐งฌ
Genes Analyzed
2,000
Highly variable genes
Module Dendrogram
Hierarchical clustering of expression correlations in the stratified sample.
Module-Cell Type Association
Module eigengene activity across cell types.
Descriptive Marker RankingCell-type marker ranking in sampled cells; not donor-level differential inference
๐
Ranked Marker Rows
547
Cell-level descriptive thresholds; no independent donor replicates
๐ท๏ธ
Cell Types Compared
8
Cell populations analyzed
Marker Ranking Volcano Plot
Cell-level descriptive marker ranking; not donor-level differential inference.
Marker Gene Heatmap
Z-score normalized expression of top marker genes per cell type.
๐ Top Marker Genes
| names | scores | logfoldchanges | pvals | pvals_adj | pct_nz_group | pct_nz_reference | cell_type |
|---|---|---|---|---|---|---|---|
| SLC1A2 | 17.1749 | 4.6803 | 0 | 0 | 0.7267 | 0.1424 | Astrocytes |
| FGFR2 | 18.3209 | 4.4752 | 0 | 0 | 0.85 | 0.2553 | Astrocytes |
| PREX1 | 15.3075 | 3.9485 | 0 | 0 | 0.6933 | 0.1769 | Astrocytes |
| SLC6A11 | 14.7391 | 3.6991 | 0 | 0 | 0.7433 | 0.2131 | Astrocytes |
| SYTL1 | 4.0924 | 3.4336 | 0 | 0.0033 | 0.1733 | 0.0211 | Astrocytes |
| SWAP70 | 10.663 | 3.3633 | 0 | 0 | 0.4967 | 0.1019 | Astrocytes |
| SALL1 | 4.4185 | 3.3162 | 0 | 0.0009 | 0.19 | 0.0253 | Astrocytes |
| DOCK8 | 6.2437 | 3.2156 | 0 | 0 | 0.2767 | 0.0455 | Astrocytes |
| AHNAK | 12.5151 | 3.1214 | 0 | 0 | 0.7633 | 0.2856 | Astrocytes |
| LHX2 | 4.6523 | 3.1104 | 0 | 0.0003 | 0.2067 | 0.0337 | Astrocytes |
| FLI1 | 6.0247 | 6.3521 | 0 | 0 | 0.2543 | 0.0072 | Endothelial cells |
| EGFL7 | 6.2075 | 6.1986 | 0 | 0 | 0.2629 | 0.008 | Endothelial cells |
Showing top 12 rows
Metabolism AnalysisCurated metabolic gene-set expression scores; descriptive only
๐งช
Pathways Scored
12
Metabolic pathway gene sets tested
โ
Pathways Detected
12
Pathways with genes expressed in data
๐ท๏ธ
Cell Types Analyzed
8
Cell populations scored
Top Metabolic Pathways
Metabolic Pathway Heatmap
Curated metabolic gene-set expression scores across sampled cell types.
Top Metabolic Activities
Top pathway-cell type combinations ranked by activity score. Dot size: genes detected.
Disease AssociationCurated disease-gene set overlap; descriptive only
๐ฌ
Diseases Tested
15
Disease categories analyzed
โ
Significant Associations
3
Cell type-disease links (adj. p < 0.05)
Top Associated Diseases
Disease Association Heatmap
Curated disease-gene set overlap across sampled cell types; descriptive only.
Top Disease Associations
Dot size: overlap genes. Color: significance.
Drug Target AnalysisCurated drug-target expression matching; descriptive only
๐
Drugs Screened
18
Drug compounds evaluated
๐ฏ
Drugs with Targets
14
Drugs with target genes detected in data
๐ท๏ธ
Cell Types Analyzed
8
Cell populations scored
Top Associated Drugs
Drug Target Expression Heatmap
Curated drug-target expression scores across sampled cell types; descriptive only.
Top DrugโCell Type Associations
Dot size: % cells expressing targets. Color: number of targets detected.
๐ DrugโCell Type Scores
| drug | cell_type | category | indication | targets_detected | targets_total | mean_target_expr | pct_cells_expressing | deg_overlap | target_genes |
|---|---|---|---|---|---|---|---|---|---|
| Imatinib | Fibroblasts | Kinase inhibitor | CML / GIST | 5 | 5 | 0.341 | 44.3182 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Excitatory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0856 | 16.6667 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Radial glial cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.2942 | 41.8182 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Oligodendrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.1878 | 30.303 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Inhibitory neurons | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0604 | 12 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Endothelial cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.1931 | 28.0172 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Astrocytes | Kinase inhibitor | CML / GIST | 5 | 5 | 0.256 | 37.6667 | 1 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Imatinib | Smooth muscle cells | Kinase inhibitor | CML / GIST | 5 | 5 | 0.0566 | 11.1111 | 0 | ABL1,KIT,PDGFRA,PDGFRB,CSF1R |
| Trastuzumab | Fibroblasts | mAb | Breast cancer | 1 | 1 | 0.2642 | 9.0909 | 0 | ERBB2 |
| Trastuzumab | Excitatory neurons | mAb | Breast cancer | 1 | 1 | 0.0151 | 0.6667 | 0 | ERBB2 |
| Trastuzumab | Radial glial cells | mAb | Breast cancer | 1 | 1 | 0.3408 | 11.8182 | 0 | ERBB2 |
| Trastuzumab | Oligodendrocytes | mAb | Breast cancer | 1 | 1 | 0 | 0 | 0 | ERBB2 |
Showing top 12 rows ยท Download full table above
Exploratory Analysis FilesValidated module artifacts and individual downloads
Exploratory Result Files
Use the validated per-module links below. The general Atlas ZIP endpoint is not presented as containing this linked exploratory package.
Share Results
Use this permanent link to share these analysis results:
analysis.php?SP_ID=SP587
๐ Available Result Files
| Analysis | File | Type | Action |
|---|---|---|---|
| TF Associations | grn_tf_heatmap.png | Figure (PNG) | ๐ View |
| TF Associations | grn_network.png | Figure (PNG) | ๐ View |
| TF Associations | grn_tf_activity.csv | Data (CSV) | ๐ฅ Download |
| TF Associations | grn_tf_targets.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_dendrogram.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_module_heatmap.png | Figure (PNG) | ๐ View |
| Co-expression | coexp_modules.csv | Data (CSV) | ๐ฅ Download |
| Co-expression | coexp_eigengenes.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_volcano.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_marker_heatmap.png | Figure (PNG) | ๐ View |
| Marker Ranking | deg_top_markers.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_significant.csv | Data (CSV) | ๐ฅ Download |
| Marker Ranking | deg_all_results.csv | Data (CSV) | ๐ฅ Download |
| Metabolism | metabolism_heatmap.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_dotplot.png | Figure (PNG) | ๐ View |
| Metabolism | metabolism_scores.csv | Data (CSV) | ๐ฅ Download |
| Disease | disease_heatmap.png | Figure (PNG) | ๐ View |
| Disease | disease_dotplot.png | Figure (PNG) | ๐ View |
| Disease | disease_enrichment.csv | Data (CSV) | ๐ฅ Download |
| Drug Analysis | drug_heatmap.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_dotplot.png | Figure (PNG) | ๐ View |
| Drug Analysis | drug_scores.csv | Data (CSV) | ๐ฅ Download |
| Report | SP587_summary.json | Summary (JSON) | ๐ฅ Download |