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Cell Type
Cell Type Overview
Chondrocytes responding to inflammatory cytokines (e.g., IL-1ฮฒ, TNF-ฮฑ) in diseased joints (e.g., osteoarthritis, RA). They upregulate the production of inflammatory mediators (NO, PGE2) and catabolic enzymes (MMPs, ADAMTS), creating a destructive feedback loop that degrades cartilage. This state represents a shift from homeostatic maintenance to a pathology-driving phenotype.
Cell Type UMAP Atlas & Gene Explorer
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Cell Distribution โ WebGL
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Related Cell Types
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