Enteric glial cells

Enteric glial cells (EGCs) are the resident glia of the enteric nervous system (ENS), the "gut brain." They resemble CNS astrocytes and are integral to gastrointestinal homeostasis. EGCs support enteric neurons, regulate intestinal barrier integrity, modulate immune responses within the gut wall, and influence motility. Their dysfunction is implicated in inflammatory bowel diseases (IBD), infections, and functional GI disorders, highlighting their role beyond mere structural support.