Medullary thymus epithelial cells ๐Ÿงฌ Cell Type
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Medullary thymus epithelial cells

MTE
Epithelial cells
Major003CT047AA
Cell Type ID
MTE
Abbreviation
1
Tissues
SP121
Species
Statistics Analysis

Cell Type Overview

Medullary thymic epithelial cells (mTECs) are a specialized stromal cell population in the thymus medulla. They play a crucial role in central tolerance by expressing a wide array of tissue-specific antigens (promiscuous gene expression) under the control of the AIRE transcription factor. They present these self-antigens to developing thymocytes, enabling the deletion of self-reactive T cells (negative selection) to prevent autoimmunity.

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