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Cell Type
Hypertrophic chondrocytes
HTC
Stromal cells
Cell Type Overview
The final stage of chondrocyte differentiation in the growth plate during endochondral ossification. These cells enlarge (hypertrophy), dramatically alter their matrix to promote calcification (secrete type X collagen), and express factors like VEGF that attract blood vessels and osteoclasts. Ultimately, they undergo apoptosis or transdifferentiation, leaving behind a calcified scaffold that is replaced by bone.
Cell Type UMAP Atlas & Gene Explorer
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Cell Types
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Cell Type
Expression
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