Cycling B cells

Cycling B cells refer to B lymphocytes that are actively proliferating, progressing through the cell cycle (G1, S, G2, M phases). This occurs during immune activation following antigen encounter and T cell help, leading to clonal expansion within germinal centers of lymph nodes or in extrafollicular sites. This proliferation is essential to generate a large population of antigen-specific B cell clones for antibody production and memory formation.