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Cell Type
Cell Type Overview
Osteoclasts are large multinucleated cells of the monocyte/macrophage lineage that resorb bone by secreting protons and lysosomal enzymes such as cathepsin K onto the bone surface. Together with bone-forming osteoblasts, they maintain skeletal homeostasis through continuous remodeling. Excessive osteoclast activity drives bone loss in osteoporosis and inflammatory bone disease.
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