Human SP121 cell atlas ยท biomarker gene
klotho
Compare the same human-cell UMAP twice: cell-type identity above and KL expression below. Matching coordinates make high-expression cell populations directly comparable.
Curated biomarker context
Klotho Anti-aging Protein
Curated longevity-gene record; the linked publication is the evidence record shown in the LACA source table.
PMID 30633899 โKlotho
Anti-aging protein associated with cognitive and kidney health; the approved human gene symbol is KL.
PMID 19230844 โKlotho (KL) protein
Soluble Klotho declines with age; anti-aging hormone modulating insulin/IGF-1 and phosphate metabolism.
PMID 19230844 โMatched-coordinate comparison
Both panels use the same 20,321 cells and UMAP coordinates. Hover or focus a linked row in the cell-type ranking to highlight that population in both maps.
29 annotated cell types
Colors identify cell types. Labels mark the leading KL-expressing populations.
Gray = undetected ยท yellow = high
Color is scaled to the 99th percentile of positive expression so rare outliers do not flatten the visible pattern.
Expression summary
Select a cell name to open its closest standardized LACA cell profile. Images represent that mapped standard cell family while the table retains the atlas subtype label.
| Rank | Cell type | Cells | Mean expression | % expressing | Maximum |
|---|
Values are read directly from the source SP121 H5AD expression matrix and summarized descriptively by annotated cell type. Expression does not establish a causal effect on aging or longevity.